Results 81 to 90 of about 6,270,976 (255)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Dynamical symmetry enhancement near N $$ \mathcal{N} $$ = 2, D = 4 gauged supergravity horizons

open access: yesJournal of High Energy Physics, 2017
We show that all smooth Killing horizons with compact horizon sections of 4-dimensional gauged N $$ \mathcal{N} $$ = 2 supergravity coupled to any number of vector multiplets preserve 2 c 1 K + 4 ℓ $$ 2{c}_1\left(\mathcal{K}\right)+4\ell ...
J. Gutowski, T. Mohaupt, G. Papadopoulos
doaj   +1 more source

A new methodology for anisotropic mesh refinement based upon error gradients [PDF]

open access: yes, 2004
We introduce a new strategy for controlling the use of anisotropic mesh refinement based upon the gradients of an a posteriori approximation of the error in a computed finite element solution.
Ainsworth   +33 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Study of prompt D 0 meson production in pPb collisions at s N N = 5 $$ \sqrt{s_{\mathrm{N}\;\mathrm{N}}}=5 $$ TeV

open access: yesJournal of High Energy Physics, 2017
Production of prompt D 0 mesons is studied in proton-lead and lead-proton collisions recorded at the LHCb detector at the LHC. The data sample corresponds to an integrated luminosity of 1.58±0.02 nb−1 recorded at a nucleon-nucleon centre-of-mass energy ...
The LHCb collaboration   +811 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

N $$ \mathcal{N} $$ = (4, 4) supersymmetric AdS3 solutions in d = 11

open access: yesJournal of High Energy Physics
We derive necessary and sufficient conditions for AdS3 solutions of d = 11 supergravity to preserve N $$ \mathcal{N} $$ = (1, 1) supersymmetry in terms of G-structures.
Andrea Conti, Niall T. Macpherson
doaj   +1 more source

Е-кадеринот и неговата улога кај пациентки Ñо Ñерозен оваријален карцином во напреднат Ñтадиум [PDF]

open access: yes, 2017
Ovarian cancer is the fifth leading cause of cancer deaths and has the highest mortality rate among gynecologic cancers in women in North America and Europe.The aim of this study wasto analyze the correlation between E-cadherin expression and clinical ...
ÐлулоÑки, Игор
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

N-(2-Acetamido-2-deoxy-β-d-glucopyranosyl)-N-(3-azidopropyl)-O-methylhydroxylamine

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2016
The structure of the title compound, C12H23N5O6, solved using adequate data from a thin crystal plate, confirmed that this useful glycoconjugate was obtained in the ring-closed β-pyranose configuration with 4C1 conformation.
Stefan Munneke   +3 more
doaj   +1 more source

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