The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta-Analysis of the European Myeloma Network (EMN). [PDF]
Am J HematolOur meta‐analysis showed significant improvement of PFS with lenalidomide, proteasome inhibitors, and CD38‐based therapies. A significant OS benefit was noted only with lenalidomide in transplant‐eligible (TE) patients, while CD38‐directed therapy showed a trend toward improved OS.
Ludwig H +25 more
europepmc +2 more sources
Minimally invasive characterization of peripheral blood measurable residual disease in multiple myeloma using high-sensitivity detection of ctDNA by next-generation sequencing. [PDF]
HemasphereAbstract Measurable residual disease assessment in bone marrow (BM‐MRD) is a crucial prognostic factor in multiple myeloma (MM), but its clinical use has some caveats, such as invasiveness, poor spatial representativity, and serial sampling. Novel minimally invasive approaches for monitoring peripheral residual disease (PRD) could facilitate its ...
Buenache N +31 more
europepmc +2 more sources
A critical analysis of the IMWG multiple myeloma complete response criterion in the era of mass spectrometry. [PDF]
HemasphereHemaSphere, Volume 10, Issue 2, February 2026.
Puig N +25 more
europepmc +2 more sources
Bispecific antibodies targeting B-cell maturation antigen in multiple myeloma: Current clinical applications, challenges and future directions. [PDF]
CancerAbstract Anti‐B cell maturation antigen (BCMA) therapies, including antibody‐drug conjugates, chimeric antigen receptor T cells, and bispecific antibodies (bsAbs), have recently revolutionized the treatment landscape of multiple myeloma. This review outlines the biologic rationale for targeting BCMA and sheds light on the mechanism of action of bsAbs ...
Manzato E +5 more
europepmc +2 more sources
Semelhanças e Especificidades entre os Estudos do Ócio e os Estudos do Lazer
Revista Subjetividades, 2018 As concepções teóricas dos estudos do ócio e dos estudos do lazer apresentam semelhanças e especificidades quanto à análise dos fenômenos culturais.
Marcos Gonçalves Maciel +2 more
doaj +1 more source
Revista Subjetividades, 2020 Este trabalho é uma resenha do filme “Cam” (Goldhaber, 2018), cuja narrativa pode ser compreendida à luz dos mecanismos subjetivos e tecnológicos atuantes sobre as pessoas no ciberespaço.
Gláucia Rebeca Teixeira de Oliveira +1 more
doaj +1 more source
Global Policy, EarlyView.ABSTRACT Recent shifts in European security have placed resilience at the center of deterrence and defense strategies. While resilience has traditionally been understood as the ability to withstand disruption and sustain military operations, there have been calls for a whole‐of‐society approach that strengthens societies against hybrid threats and ...
Jan Daniel, Míla O'Sullivan
wiley +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2011 Avaliou-se a influência do teor de concentrado na dieta sobre o comportamento ingestivo, o consumo e a digestibilidade aparente de nutrientes em bovinos.
S.R. Goularte +6 more
doaj +1 more source
O consumo de produtos de moda visto a partir de experiências de ócio
Projetica, 2015 Este artigo busca problematizar a associação entre o consumo de produtos de moda e a vivência de momentos de ócio, uma vez que estas atividades apresentariam como semelhanças o restabelecimento de forças gastas nas atividades laborais.
Natália Parente Pinheiro +2 more
doaj +1 more source
Feedback Protocols for Dissipation Control in Small Systems
Annalen der Physik, Volume 538, Issue 11, November 2026.Single‐molecule pulling experiments recover folding free energies from irreversible work, but dissipation biases the result. Comparing feedback protocols on a model DNA hairpin at equal measurement time, the authors show that reduced dissipation does not always improve free‐energy estimates.
S. Peyriere, F. Ritort
wiley +1 more source