Results 91 to 100 of about 8,514 (110)

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, Volume 36, Issue 5, September 2026.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

Fast and accurate visual acuity prediction based on optical aberrations and machine learning

Scientific Reports
In this work, we propose three machine learning-based methods for predicting visual acuity (VA). Two methods utilize regression trees (LSBoost and XGBoost), and the third employs a neural network that classifies simulated aberrated optotypes as ...
A. Sierra, I. Baoud-Ould-Haddi, S. Fernández-Núñez, J. A. Gómez-Pedrero, M. García-Montero, N. Garzón, J. Alonso, E. Pascual, J. Vargas   +8 more
doaj   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

Planar Super‐Oscillation Diffractive Lenses: Practical Developments and Applications

Nanophotonics, Volume 15, Issue 16, 26 August 2026.
This review examines planar super‐oscillation diffractive lenses as a unified framework for super‐oscillatory lenses and supercritical lenses. It focuses on applications in super‐resolution imaging, micro/nanofabrication, and precision measurement and relates their application‐specific requirements to focal‐field control, multiobjective design ...
Yutian Cheng, Lingyi Tang, Xingcheng Xiao, Xiaochang Yu, Ya Guo, Yiting Yu, Wenli Li   +6 more
wiley   +1 more source

Revealing regional variations in scleral shear modulus in a rabbit eye model using multi-directional ultrasound optical coherence elastography

Scientific Reports
The mechanical properties of the sclera play a critical role in supporting the ocular structure and maintaining its shape. However, non-invasive measurements to quantify scleral biomechanics remain challenging.
Lupe Villegas, Fernando Zvietcovich, Susana Marcos, Judith S. Birkenfeld   +3 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, Volume 30, Issue 4, Page 536-543, August 2026.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1673-1685, August 2026.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Towards Advanced Intelligent and Perceptive Soft Grippers

Advanced Intelligent Systems, Volume 8, Issue 8, August 2026.
Implementing soft yet strong and intelligent soft grippers request innovative and creative solutions in designing soft bodies and seamlessly integrating actuated systems with hierarchical sensing. This review systematically analyses soft grippers with a deep understanding of core components, from fundamental design principles to actuation and sensing ...
Haneul Kim, Hayeon Shin, Seik Park, Changbeom Shim, Seonggun Joe   +4 more
wiley   +1 more source

The cGAS–STING Pathway Drives Astrocyte‐Mediated Demyelination in Multiple Sclerosis Through Clusterin Secretion

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
In multiple sclerosis, astrocytes detect extracellular DNA via the cGAS–STING pathway, triggering Clusterin secretion that induces oligodendrocyte apoptosis and demyelination. Pharmacological STING inhibition with H‐151 suppresses this neurotoxic cascade, preserves myelin integrity, and ameliorates clinical disability in experimental autoimmune ...
Shengfei Hu, Xia Xiao, Xi Cheng, Yiying Huang, Tingting Cui, Shishi Shen, Chunping Cui, Li Xiao, Hanzhang Tan, Wei Qiu, Yipeng Zhao, Rui Li   +11 more
wiley   +1 more source

Atorvastatin Reduces Alcohol‐Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol‐Disulfide Imbalance in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Atorvastatin (40 mg/kg) inhibited fibrosis, hypertrophy, apoptosis, inflammation, and oxidative stress caused by alcohol consumption. It may contribute to the regulation of mitochondrial function and thiol/disulfide balance by limiting alcohol‐related heart and liver damage.
Cumaali Demirtas, Şahhan Kılıç, Mert Babaoğlu, Süha Asal, Elif Gökçe Tenekeci, Hakan Beyaztaş, Eray Metin Guler, Salime Pelin Erguven, Kubra Sevgin   +8 more
wiley   +1 more source