Results 91 to 100 of about 1,298,122 (296)

Čas generací

open access: yesSociální studia, 2016
Text rozvíjí diskurzivně-pragmatický koncept Mannheimovy teorie generace, především jeho myšlenku generace jako skutečnosti, která zdůrazňuje kolektivní kognitivní pozadí neboli horizont generace.
Michael Corsten
doaj  

The Optimized Switching [PDF]

open access: yes, 2018
Práce se zabývá teorií spínání, čili zapínáním a vypínáním v uzemněné, nebo neuzemněné soustavě. Zabývá se optimalizací řízeného spínání pomoci zařízení Switchsync PWC600.
Reder, Zdeněk
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Relaxation times in the polymer gel electrolytes by magnetic resonance methods [PDF]

open access: yes, 2009
Cílem bakalářské práce je změření relaxací gelových struktur technikami magnetické rezonance. V první části je podrobně popsána teorie potřebná k následnému měření.
Jehličková, Lenka
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

The Museum on the Edge of Forever [PDF]

open access: yes, 2014
This article argues that understanding any space or site relies on a knowledge of its fourth dimension - the timescape. It will explore this by situating the investigation in the museum - a place of heightened contrivance which could easily be shallowly ...
Walklate, Jenny
core  

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

open access: yesNature Biotechnology, 2014
Clustered, regularly interspaced, short palindromic repeat (CRISPR) RNA-guided nucleases (RGNs) are highly efficient genome editing tools. CRISPR-associated 9 (Cas9) RGNs are directed to genomic loci by guide RNAs (gRNAs) containing 20 nucleotides that ...
Yanfang Fu   +4 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Henri Poincaré, Číslo – prostor – čas

open access: yesTeorie vědy, 2011
Review: Henri POINCARÉ, Číslo – prostor – čas. Výbor prací o filosofii vědy. Uspořádal a přeložil Jiří Fiala. Kanina: OPS 2010, 227 s.
Jan Maršálek
doaj  

Costs Optimalization in a Selected Organization [PDF]

open access: yes, 2011
Import 04/07/2011RESUMÉ Názov diplomovej práce: Optimalizácia nákladov na manipulačné jednotky vo vybranej organizácii Autor diplomovej práce: Bc. Marek Ponechal Kľúčové slová: manipulačná jednotka, znižovanie nákladov, Multipack KLT, mzdová nákladovosť,
Ponechal, Marek
core  

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