Results 51 to 60 of about 164,635 (296)
Kultura kao afirmacija i negacija, Ne-kultura, Ne-kulturi [PDF]
Pojam „kultura“ etimološki znači njegovanje, uzgajanje, obrađivanje. Uz kulturu se vežu vrijednosti i u osnovi zvuči uzvišeno. Stoga Ne-kulturu prije svega poimamo vrijednosno negativno, kao njenu negaciju, rušenje, agresiju.
Kodrnja, Jasenka
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Projectification and Conflicting Temporalities in Academic Knowledge Production [PDF]
The project format has become a standard and self-evident way to organize research work in today's accelerated university context, leading to the projectification of science.
Ylijoki, Oili-Helena
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Slovansko-st. indijska izoglosa za pojem “čas”
F. Bezlaj v rokopisu svoje kritike Skokovega etimološkega slovarja sbh. jezika, ki bo izšla predvidoma v Etimologiji VII, Moskva, navaja sbh. dial. čelo »dan, dvanajst ur«, dani noc su dva čela (Risanj, Boka Kotorska) in v Črni gori kolje »Zeit, freie ...
Varja Cvetko
doaj +1 more source
Biopotraviny, biomed a pesticidy [PDF]
Čas od času se v médiích objeví zpráva varující spotřebitele, že potraviny obsahují pesticidy. A jak je to možné, když mají být potraviny "ekologicky čisté".
Rozsypal, Roman
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The Museum on the Edge of Forever [PDF]
This article argues that understanding any space or site relies on a knowledge of its fourth dimension - the timescape. It will explore this by situating the investigation in the museum - a place of heightened contrivance which could easily be shallowly ...
Walklate, Jenny
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