Results 41 to 50 of about 164,635 (296)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Svět mezi řádky : prolegomena k výzkumu Čapkovy cestopisné tvorby

open access: yesBohemica Litteraria, 2013
The study analyzes several aspects of Čapek's travelogues: presentation of the space that is constructed as a system of archetypal universals (e.g. the mountain, the house, the sea, the city) and time that complements the first category.
Agnieszka Janiec-Nyitrai
doaj  

KOOPERATIVNO UČENJE U NASTAVI FIZIČKOG VASPITANJA

open access: yesNaša Škola
U obrazovanju se konstantno preispituju modeli učenja i/ili osmišljavaju novi koji bi učenike pripremili za život u društvu u danas veoma promenjivom okruženju. Istovremeno se socijalnom i emocionalnom učenju (eng.
Svetlana Buišić, Dragan Cvejić
doaj   +1 more source

Čas za reformo Zoisovega štipendiranja

open access: yesPsihološka Obzorja, 2016
V prispevku sta predstavljena zgodovina razvoja štipendiranja nadarjenih in razvoj meril ter kriterijev za dodelitev štipendij od začetkov štipendiranja nadarjenih do sprememb leta 2008, ko se je začel uporabljati nov zakon o štipendiranju.
Mirt Nagy
doaj   +1 more source

Reorganizacije slovenske policije [PDF]

open access: yes, 2012
Namen prispevka je analizirati rezultate projekta javne varnosti, ki je prinesel spremembe v policijski organiziranosti na lokalnem, regionalnem in državnem nivoju in narediti primerjavo z reorganizacijo policijske organizacije, ki poteka ta ...
Anželj, Darko
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

African therapy for a fractured world(view): The life of founder bishop Johannes Richmond and the invention of tradition and group cohesion in an African Initiated Church

open access: yesHTS Teologiese Studies/Theological Studies, 2015
In the book The invention of tradition historian Eric Hobsbawm claims that the process of the invention of tradition serves the formation of group cohesion. The different versions of the life story of the founder bishop of the Corinthian Church of South
Cas Wepener
doaj   +1 more source

Information in the Context of Philosophy and Cognitive Sciences [PDF]

open access: yes, 2013
This textbook briefly maps as many as possible areas and contexts in which information plays an important role. It attempts an approach that also seeks to explore areas of research that are not commonly associated, such as informatics, information and ...
Slavkovsky, Adrian
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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