Results 21 to 30 of about 36,674 (196)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Integrating Multicultural Subject Matters into Teaching Strategies of Elementary School Teachers (The U.S. State of Kansas) [PDF]

Revija za Elementarno Izobraževanje, 2014
The following academic article is based on a PhD thesis that is currently being completed, titled Education and Qualifications of Elementary School Teachers in the U.S. State of Kansas and Slovenia for teaching in classes with immigrant children.
Stanka Lunder Verlič
doaj  

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Impact of 8-week endurance training on qualitative and quantitative parameters of stroke volume

Zdravniški Vestnik, 2014
Background: Dynamics of stroke volume during increasing progressive load varies widely among individuals. The data of current studies describing the impact of long-term endurance training on the dynamics of cardiac stroke volume are conflicting.
Suzana Pustivšek, Irena Auersperger, Branko Škof   +2 more
doaj  

Dejavniki gibalne aktivnosti in z zdravjem povezane kakovosti življenja

Obzornik zdravstvene nege, 2014
Uvod: Gibalna aktivnost koristi telesnemu in duševnemu zdravju. Namen članka je ugotoviti dejavnike, ki vplivajo nanjo, in možne ukrepe za povečanje te dejavnosti.
Renata Slabe Erker, Simon Ličen
doaj   +1 more source

Rokomet na invalidskih vozičkih kot okupacija pri osebah s poškodbo hrbtenjače

Revija za Zdravstvene Vede, 2022
Udejstvovanje v invalidskem športu daje osebam, vezanim na invalidski voziček, priložnost za pozitivne izkušnje in izboljšanje spretnosti, potrebnih za izvajanje vsakodnevnih dejavnosti, kar prispeva k višji kakovosti njihovega življenja.
Neža Mandelc, Cecilija Lebar
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Anxiety, Self-Esteem and Coping With Stress in Secondary School Students in Relation to Involvement in Organized Sports / Anksioznost, Samospoštovanje In Spoprijemanje S Stresom Pri Srednješolcih V Povezavi Z Vključenostjo V Organizirano Športno Aktivnost

Slovenian Journal of Public Health, 2015
Cilj. Namen raziskave je bil preučiti raven samospoštovanja in anksioznosti ter uporabo različnih strategij spoprijemanja s stresom pri srednješolskih mladostnikih v povezavi z vključenostjo v redno in organizirano športno vadbo.
Dolenc Petra
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source