Results 101 to 110 of about 30,763 (155)
ZAN, IZUMO1, and TMEM95 Protein Domains Identify the Physiological Status of the Sperm
Andrology, EarlyView.ABSTRACT Background Infertility is a growing concern, which has led to an increase in the use of assisted reproductive techniques, involving in vitro sperm capacitation. Nonetheless, the optimal capacitation time remains a matter of debate, and it is unknown whether it has an impact on the localization of key membrane proteins.
Miranda Hernández‐Falcó +5 more
wiley +1 more source
Anthropology of Consciousness, EarlyView.ABSTRACT When mural art in indigenous communities is commissioned as a participatory project, several methodological, epistemological, and aesthetic questions arise. This text proposes a horizontal and investigative approach to what we can simply call ‘muralism in the A'i Cofán community context,’ not as significant works executed in communities, but ...
Daniel Alberto Restrepo Hernández +2 more
wiley +1 more source
Veterinarian attitudes towards immunocontraceptive use in cats
Australian Veterinary Journal, EarlyView.Background The continuously expanding global cat population poses concerns to public health, native ecosystems and individual animal welfare. These concerns have led to additional management strategies to reduce unowned cat numbers, including the development of feline immunocontraceptives.
E Vartola +4 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz +8 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar +6 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso +3 more
wiley +1 more source
Habitat and spatial trends of U.K. wintering waterbird populations over 50 years
Conservation Biology, EarlyView.Abstract The United Kingdom is an important wintering ground for millions of waterbirds. Most U.K. wintering waterbird populations increased between 1970 and the mid‐1990s, but declined thereafter. We examined U.K. population indices in 46 wintering waterbird species in two 25‐year periods, 1970–1994 and 1995–2019, to identify which waterbird groups ...
Blaise Martay +8 more
wiley +1 more source
Risks of concealing environmental degradation
Conservation Biology, EarlyView.Abstract Current practice seeks to conceal the visual impact of land‐use change (i.e., development). Six percent of development impact assessments in Australia and 14% of the World Bank's assessments recommend visual impact mitigation. This mitigation results in, for example, vegetated buffer strips alongside cleared agricultural areas and earthen ...
Matt W. Hayward +8 more
wiley +1 more source
Scientists’ warning on the global destruction of rock outcrop ecosystems
Conservation Biology, EarlyView.Abstract Rock outcrops are geological formations that harbor a highly specialized biota adapted to harsh environmental conditions that differ from their surrounding landscapes. They are globally distributed, especially in old, highly weathered landscapes, and can function as habitat islands containing high levels of endemism and distinct evolutionary ...
Luiza F. A. de Paula +19 more
wiley +1 more source