Results 1 to 10 of about 3,003 (109)

PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration

Cancer Medicine
Background As an essential transcription factor, Myc‐associated zinc‐finger protein (MAZ) is frequently upregulated in many human tumors and is a well‐documented oncogene. However, we found high expression of MAZ was closely associated with good survival
Dong Xing, Ting Zhao, Chenchen Mao, Zheng Han, Wanxia Cai, Teming Zhang, Dianfeng Mei, Wangkai Xie, Jiaye Yu, Zhonghan Wu, Zhiyuan Chen, Shiyu Feng, Xian Shen, Xiangyang Xue, Dan Xiang   +14 more
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G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis

Nature Communications
G-quadruplexes (G4s) can recruit transcription factors to activate gene expression, but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 promoter propel the motility in MAZ phase-separated condensates and subsequently ...
Wenmeng Wang, Dangdang Li, Qingqing Xu, Jiahui Cheng, Zhiwei Yu, Guangyue Li, Shiyao Qiao, Jiasong Pan, Hao Wang, Jinming Shi, Tongsen Zheng, Guangchao Sui   +11 more
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MAZ-mediated N6-methyladenosine modification of ZEB1 promotes hepatocellular carcinoma progression by regulating METTL3

Journal of Translational Medicine
Background Hepatocellular carcinoma (HCC) has a hidden onset and high malignancy. Its high metastasis, high recurrence, and short survival time have always been a difficult and hot spot in clinical practice.
Di Li, Li Xu, Ruyuan Liu, Zhaonv Yao, Chuanjun Zheng, Song Jin, Xuefeng Guo, Zhengbao Zhang, Shengkui Tan, Xiaonian Zhu   +9 more
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PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter

Epigenetics & Chromatin, 2023
Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellular processes, including tumorigenesis. However, the function and expression of PCGF6 in papillary RCC (pRCC) remain unclear. In the
Meng Zhu, Ruo-Nan Zhang, Hong Zhang, Chang-bao Qu, Xiao-chong Zhang, Li-Xin Ren, Zhan Yang, Jun-Fei Gu   +7 more
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Low-Cost and Environmental-Friendly Route for Synthesizing Nano-Rod Aluminosilicate MAZ Zeolite

Molecules, 2022
Preparation of nano-rod aluminosilicate Mazzit (MAZ) zeolite under low-cost and environmental-friendly route is attractive, but still challenging.
Fen Zhang, Wei Chen, Lingling Wang, Weiguo Song, Yin Hu   +4 more
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MAZ regulates fetal hemoglobin repression by activating MYB transcription

Scientific Reports
β-hemoglobinopathies, such as sickle cell disease and β-thalassemia, are common genetic disorders remaining significant global health challenges due to their associated morbidity and mortality.
Dian Lu, Yinghong Yang, Bo Yang, Diyu Chen, Mingming Zhu, Siqi Huang, Jun Hu, Lifen Zhu, Weimin Fan, Yingjun Xie, Bing Song, Peng Huang, Xiaofang Sun   +12 more
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Single-cell and spatial transcriptome analyses reveal MAZ(+) NPC-like clusters as key role contributing to glioma recurrence and drug resistance

Journal of Translational Medicine
Background Temozolomide (TMZ) is an important chemotherapeutic agent for glioma treatment. However, the emergence of drug resistance impedes its application. Traditional population-level studies are limited in elucidating resistance mechanisms.
Qiang Gu, Kan Wang, Tingming Lu, Yifei Xiao, Yaqing Wu, Hang Zhou, Kaijia Zhou   +6 more
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Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma

Communications Biology
Myc-associated Zinc-finger Protein (MAZ) has been implicated in the malignant progression of various tumors. However, its expression and functional relationship of MAZ in melanoma have not been previously investigated.
Yu Feng, Qinxuan Ni, Na Wu, Taiyu Xie, Fang Yun, Xuedan Zhang, Lingnan Gao, Yanlong Gai, Enjiang Li, Xiaojia Yi, Junlin Xie, Qiao Zhang, Zhe Yang, Buqing Sai, Yingmin Kuang, Yuechun Zhu   +15 more
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MAZ promotes prostate cancer bone metastasis through transcriptionally activating the KRas-dependent RalGEFs pathway

Journal of Experimental & Clinical Cancer Research, 2019
Background Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However,
Qing Yang, Chuandong Lang, Zhengquan Wu, Yuhu Dai, Shaofu He, Wei Guo, Shuai Huang, Hong Du, Dong Ren, Xinsheng Peng   +9 more
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Suppression of pentraxin 3 inhibits human osteosarcoma cell metastasis by repressing MAZ through STAT3 pathway

Cancer Cell International
Background Pentraxin 3 (PTX3), also known as TNF-inducible gene 14 protein (TSG-14), exerts pleiotropic roles in inflammation, immune responses, and a myriad of cancers, but there is limited knowledge regarding the role of PTX3 in the metastasis of human
Chia-Hsuan Chou, Yi-Hsien Hsieh, Pei-Ni Chen, Jia-Sin Yang, Chih-Hsin Tang, Shun-Fa Yang, Ko-Hsiu Lu   +6 more
doaj   +2 more sources