Results 11 to 20 of about 3,015 (109)

PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration

Cancer Medicine
Background As an essential transcription factor, Myc‐associated zinc‐finger protein (MAZ) is frequently upregulated in many human tumors and is a well‐documented oncogene. However, we found high expression of MAZ was closely associated with good survival
Dong Xing, Ting Zhao, Chenchen Mao, Zheng Han, Wanxia Cai, Teming Zhang, Dianfeng Mei, Wangkai Xie, Jiaye Yu, Zhonghan Wu, Zhiyuan Chen, Shiyu Feng, Xian Shen, Xiangyang Xue, Dan Xiang   +14 more
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MAZ-mediated N6-methyladenosine modification of ZEB1 promotes hepatocellular carcinoma progression by regulating METTL3

Journal of Translational Medicine
Background Hepatocellular carcinoma (HCC) has a hidden onset and high malignancy. Its high metastasis, high recurrence, and short survival time have always been a difficult and hot spot in clinical practice.
Di Li, Li Xu, Ruyuan Liu, Zhaonv Yao, Chuanjun Zheng, Song Jin, Xuefeng Guo, Zhengbao Zhang, Shengkui Tan, Xiaonian Zhu   +9 more
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G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis

Nature Communications
G-quadruplexes (G4s) can recruit transcription factors to activate gene expression, but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 promoter propel the motility in MAZ phase-separated condensates and subsequently ...
Wenmeng Wang, Dangdang Li, Qingqing Xu, Jiahui Cheng, Zhiwei Yu, Guangyue Li, Shiyao Qiao, Jiasong Pan, Hao Wang, Jinming Shi, Tongsen Zheng, Guangchao Sui   +11 more
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Single-cell and spatial transcriptome analyses reveal MAZ(+) NPC-like clusters as key role contributing to glioma recurrence and drug resistance

Journal of Translational Medicine
Background Temozolomide (TMZ) is an important chemotherapeutic agent for glioma treatment. However, the emergence of drug resistance impedes its application. Traditional population-level studies are limited in elucidating resistance mechanisms.
Qiang Gu, Kan Wang, Tingming Lu, Yifei Xiao, Yaqing Wu, Hang Zhou, Kaijia Zhou   +6 more
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Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma

Communications Biology
Myc-associated Zinc-finger Protein (MAZ) has been implicated in the malignant progression of various tumors. However, its expression and functional relationship of MAZ in melanoma have not been previously investigated.
Yu Feng, Qinxuan Ni, Na Wu, Taiyu Xie, Fang Yun, Xuedan Zhang, Lingnan Gao, Yanlong Gai, Enjiang Li, Xiaojia Yi, Junlin Xie, Qiao Zhang, Zhe Yang, Buqing Sai, Yingmin Kuang, Yuechun Zhu   +15 more
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MAZ regulates fetal hemoglobin repression by activating MYB transcription

Scientific Reports
β-hemoglobinopathies, such as sickle cell disease and β-thalassemia, are common genetic disorders remaining significant global health challenges due to their associated morbidity and mortality.
Dian Lu, Yinghong Yang, Bo Yang, Diyu Chen, Mingming Zhu, Siqi Huang, Jun Hu, Lifen Zhu, Weimin Fan, Yingjun Xie, Bing Song, Peng Huang, Xiaofang Sun   +12 more
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Suppression of pentraxin 3 inhibits human osteosarcoma cell metastasis by repressing MAZ through STAT3 pathway

Cancer Cell International
Background Pentraxin 3 (PTX3), also known as TNF-inducible gene 14 protein (TSG-14), exerts pleiotropic roles in inflammation, immune responses, and a myriad of cancers, but there is limited knowledge regarding the role of PTX3 in the metastasis of human
Chia-Hsuan Chou, Yi-Hsien Hsieh, Pei-Ni Chen, Jia-Sin Yang, Chih-Hsin Tang, Shun-Fa Yang, Ko-Hsiu Lu   +6 more
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Zinc-dependent Zip7-MAZ-MYBL2 axis promotes prostate cancer metastasis

Communications Biology
Zinc, an essential trace element for healthy prostate, which dramatically decreases during prostate tumorigenesis. Targeting the key zinc signaling will be a valuable strategy for PCa therapy.
Qianxi Dong, Yunqiang Xiong, Situ Xiong, Ruize Yuan, Sheng Li, Xiangpeng Zhan, Hongji Hu, Fuchun Zheng, Wan Pang, Bin Fu, Songhui Xu, Ju Guo   +11 more
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MAZ-Mediated ubiquitin-conjugating enzyme E2C upregulation promotes breast cancer progression via the MAPK signaling pathway

Translational Oncology
Background: Malignant proliferation and invasion of tumor cells are the primary causes of death among patients with breast cancer, yet the molecular mechanisms orchestrating cancer metastasis are not well elucidated.
Jinhui Bai, Mei Deng, Xueting Wu, Chao Xiong, Huixian Wu, Li Wang, Jie Qin   +6 more
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Therapeutic targeting of circ‐CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression

EMBO Molecular Medicine, 2019
Aerobic glycolysis is a hallmark of metabolic reprogramming in tumor progression. However, the mechanisms regulating glycolytic gene expression remain elusive in neuroblastoma (NB), the most common extracranial malignancy in childhood.
Huanhuan Li, Feng Yang, Anpei Hu, Xiaojing Wang, Erhu Fang, Yajun Chen, Dan Li, Huajie Song, Jianqun Wang, Yanhua Guo, Yang Liu, Hongjun Li, Kai Huang, Liduan Zheng, Qiangsong Tong   +14 more
doaj   +2 more sources