Results 31 to 40 of about 3,015 (109)

G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy. [PDF]

PLoS ONE, 2011
HRAS is a proto-oncogene involved in the tumorigenesis of urinary bladder cancer. In the HRAS promoter we identified two G-rich elements, hras-1 and hras-2, that fold, respectively, into an antiparallel and a parallel quadruplex (qhras-1, qhras-2).
Alexandro Membrino, Susanna Cogoi, Erik B Pedersen, Luigi E Xodo   +3 more
doaj   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Experimental study on the effects of Maz Nitro additive on engine performance and emissions

South African Journal of Chemical Engineering
This study presents a comprehensive experimental investigation into the effects of Maz-Nitro additives (Maz 100 for gasoline and Maz 200 for diesel) on engine performance, fuel consumption, emissions, and material compatibility under both laboratory and ...
Pham Van Trong, Vinh Nguyen Duy, Hoang Dinh Long, Nguyen Minh Thang   +3 more
doaj   +1 more source

Rola ojca na podstawie XX homilii św. Jana Złotoustego do Listu do Efezjan

Polonia Sacra, 2014
Podział obowiązków rodzinnych, które są wyznaczone dla każdego członka rodziny, oraz harmonijne relacje rodzinne są kwestiami kluczowymi w myśli Jana Chryzostoma. Temu zagadnieniu poświęcił on homilie do Listu do Efezjan.
Dominik Jackov
doaj   +1 more source

Surface and Tropospheric Climatic Trends in the Galápagos Archipelago Based on the Galápagos Archipelago Refined Analysis Dataset

International Journal of Climatology, EarlyView.
The Galápagos Archipelago's near‐surface climate is primarily influenced by interannual El Niño‐Southern Oscillation variability, with no statistical evidence for long‐term trends in air temperature, humidity, or precipitation. While tropospheric warming and increased atmospheric stability are observed, these trends are largely decoupled from near ...
Benjamin Schmidt, Marco Otto, Frederik Bart, Nazli Turini, Byron Delgado Maldonado, Jörg Bendix, Dieter Scherer   +6 more
wiley   +1 more source

Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early‐life intestinal colonization and highlights the consequences of ...
Carly Burow, Romy Shenderey, Fariha Chowdhury, Nyah Shah, Nikhil Pai   +4 more
wiley   +1 more source

Aquaporin 1 overexpression may enhance glioma tumorigenesis by interacting with the transcriptional regulation networks of Foxo4, Maz, and E2F families

Chinese Neurosurgical Journal, 2023
Background The glioblastoma has served as a valuable experimental model system for investigating the growth and invasive properties of glioblastoma. Aquaporin-1 (AQP1) in facilitating cell migration and potentially contributing to tumor progression.
Ying Guan, Jinhuan Han, Die Chen, Yuefu Zhan, Jianqiang Chen   +4 more
semanticscholar   +1 more source

miRNA Enriched in Human Neuroblast Nuclei Bind the MAZ Transcription Factor and Their Precursors Contain the MAZ Consensus Motif

Frontiers in Molecular Neuroscience, 2017
While the cytoplasmic function of microRNA (miRNA) as post-transcriptional regulators of mRNA has been the subject of significant research effort, their activity in the nucleus is less well characterized.
Belinda J. Goldie, Belinda J. Goldie, Belinda J. Goldie, Chantel Fitzsimmons, Chantel Fitzsimmons, Judith Weidenhofer, Joshua R. Atkins, Joshua R. Atkins, Dan O. Wang, Dan O. Wang, Murray J. Cairns, Murray J. Cairns   +11 more
doaj   +1 more source

Palaeoenvironmental and climatic changes from the lateglacial of the Saalian to the Late Weichselian in central Poland: a multiproxy study from Józefów

Boreas, EarlyView.
Józefów site is a case study which provides a detailed record of environmental and climate changes and confirms the main traces of the landscape morphogenesis of the Late Pleistocene established in central‐eastern Europe. This study presents a multiproxy reconstruction of palaeoenvironment under variable climatic conditions from the retreat of the ...
Aleksandra Majecka, Jacek Forysiak, Ryszard Borówka, Andreas Börner, Łukasz Bujak, Leszek Marks, Radosław Mieszkowski, Piotr Moska, Daniel Okupny, Małgorzata Pisarska‐Jamroży, Renata Stachowicz‐Rybka, Krzysztof Stachowicz   +11 more
wiley   +1 more source

MAZ-mediated LAMA5 transcription activation promotes gastric cancer progression through the STAT3 signaling

Functional & Integrative Genomics
Laminin subunit alpha-5 (LAMA5) has been identified as an oncogene in many cancers, while its role and mechanism in gastric cancer (GC) remain to be explored. Here, the influences of LAMA5 knockdown on GC were investigated in vitro and in vivo.
Yu Wang, Jiazhong Xu, Hongxia Zhang, Xiao-bo Guo, Hongjun Liu, Qinhui Sun   +5 more
semanticscholar   +1 more source