Results 31 to 40 of about 320 (222)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 1981 In this paper define the spaces l∞(Δ), c(Δ), and c0(Δ), where for instance l∞(Δ) = {x=(xk):supk |xk -xk + l|< ∞}, and compute their duals (continuous dual, α-dual, β-dual and γ-dual).
H. Kizmaz, KIZMAZ, H
core +1 more source
The space Lq of double sequences [PDF]
, 2009 The spaces BS, BS(t), CSp, CSbp, CSr and BV of double sequences have recently been studied by Altay and Başar [J. Math. Anal. Appl. 309(1)(2005), 70–90].
Sever, Yurdal, Başar, Feyzi
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
On some difference sequence spaces of weighted means and compact operators [PDF]
, 2011 In the peresent paper, by using generalized weighted mean and difference matrix of order m, we introduce the sequence spaces X(u, v, Δ(m)), where X is one of the spaces ℓ∞, c or c0.
BaŞarir, Metin, Kara, Emrah Evren
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
On the Classical Paranormed Sequence Spaces and Related Duals over the Non-Newtonian Complex Field
Journal of Function Spaces, 2015 The studies on sequence spaces were extended by using the notion of associated multiplier sequences. A multiplier sequence can be used to accelerate the convergence of the sequences in some spaces.
Uğur Kadak +2 more
doaj +1 more source
On the Domain of the Four-Dimensional Sequential Band Matrix in Some Double Sequence Spaces
Mathematics, 2020 Let E represent any of the spaces M u , C ϑ ( ϑ = { b , b p , r } ) , and L q ( 0
Orhan Tuğ +2 more
doaj +1 more source