Results 41 to 50 of about 311 (227)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Some Topological and Geometric Properties of Some New Spaces of λ-Convergent and Bounded Series

Journal of Function Spaces, 2015
The main purpose of this study is to introduce the spaces csλ, cs0λ, and bsλ which are BK-spaces of nonabsolute type. We prove that these spaces are linearly isomorphic to the spaces cs, cs0, and bs, respectively, and derive some inclusion relations ...
Meltem Kaya, Hasan Furkan
doaj   +1 more source

Domain of q-Cesàro matrix in Hahn sequence space hd and the space bv of the sequences of bounded variation [PDF]

, 2022
Let hd = n f = (fk) ∈ ω : P k dk| fk − fk+1| < ∞ o ∩ c0, where d = (dk) is an unbounded and monotonic increasing sequence of positive reals. We study the matrix domains hd(Cq) = (hd)Cq and bv(Cq)=(bv)Cq, where Cq is the q-Cesàro matrix, 0 < q < 1.
Hazarika, Bipan, Taja, Yaying, Murat, Kirişçi, Tuğ, Orhan   +3 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

On the B-difference sequence space derived by generalized weighted mean and compact operators [PDF]

, 2012
In the present paper, by using generalized weighted mean and difference matrix B, we introduce the paranormed sequence space ℓ(u,v,p;B) which consist of all sequences whose generalized weighted B-difference means are in the linear space ℓ(p) introduced ...
Başarır, Metin, Kara, Emrah Evren
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

On Certain Sequence Spaces

, 1981
In this paper define the spaces l∞(Δ), c(Δ), and c0(Δ), where for instance l∞(Δ) = {x=(xk):supk |xk -xk + l|< ∞}, and compute their duals (continuous dual, α-dual, β-dual and γ-dual).
H. Kizmaz
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source