Results 61 to 70 of about 30,330 (245)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Toda-like (0,2) mirrors to products of projective spaces

, 2016
One of the open problems in understanding (0,2) mirror symmetry concerns the construction of Toda-like Landau-Ginzburg mirrors to (0,2) theories on Fano spaces.
Chen, Zhuo, Sharpe, Eric, Wu, Ruoxu
core   +1 more source

Classification of the N=2, Z2 X Z2-symmetric type II orbifolds and their type II asymmetric duals [PDF]

, 1999
Using free world-sheet fermions, we construct and classify all the N=2, Z2 X Z2 four-dimensional orbifolds of the type IIA/B strings for which the orbifold projections act symmetrically on the left and right movers.
Gregori, A., Kounnas, C., Rizos, J.
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On Some New Generalized Difference Sequence Spaces of Nonabsolute Type

Journal of Mathematics, 2014
We define a new triangle matrix W^=(wnkλ) by the composition of the matrices Λ=(λnk) and B(r,s,t). Also, we introduce the sequence spaces c0λ(B^),cλ(B^),l∞λ(B^), and lpλ(B^) by using matrix domain of the matrix W^ on the classical sequence spaces c0,c,l∞,
Osman Duyar, Serkan Demiriz, Osman Özdemir   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

On the Zweier Sequence Spaces of Fuzzy Numbers

International Journal of Mathematics and Mathematical Sciences, 2014
It was given a prototype constructing a new sequence space of fuzzy numbers by means of the matrix domain of a particular limitation method. That is we have constructed the Zweier sequence spaces of fuzzy numbers [ℓ∞(F)]Zη, [c(F)]Zη, and [c0(F)]Zη ...
Mehmet Şengönül
doaj   +1 more source

On Holographic Dual of the Dyonic Reissner-Nordstr\"om Black Hole

, 2010
It is shown that the hidden conformal symmetry, namely $SO(2,2) \sim SL(2,R)_L \times SL(2,R)_R$ symmetry, of the non-extremal dyonic Reissner-Nordstr\"om black hole can be probed by a charged massless scalar field at low frequencies.
Chiang-Mei Chen, E. Witten, J. M. Maldacena, Jia-Rui Sun, Ming-Fan Wu, Shou-Jyun Zou, Ying-Ming Huang   +6 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source