Results 171 to 180 of about 90,634 (287)
LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease
Movement Disorders, EarlyView.Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang +12 more
wiley +1 more source
α-Galactosidase A Augmentation by Non-Viral Gene Therapy: Evaluation in Fabry Disease Mice. [PDF]
Pharmaceutics, 2021 Rodríguez-Castejón J +6 more
europepmc +1 more source
Genetic heterogeneity of α‐galactosidase in fabry's disease [PDF]
, 1972 Giovanni Romeo +2 more
openalex +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source
α-Galactosidase a Deficiency in Fabry Disease Leads to Extensive Dysregulated Cellular Signaling Pathways in Human Podocytes. [PDF]
Int J Mol Sci, 2021 Jehn U +7 more
europepmc +1 more source
Cancer Science, EarlyView.Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa +7 more
wiley +1 more source
Twenty Novel Mutations in the α-Galactosidase A Gene Causing Fabry Disease [PDF]
, 1999 Ali Kemal Topaloğlu +6 more
openalex +1 more source
Cell Proliferation, EarlyView.During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi +7 more
wiley +1 more source
Human α-Galactosidase A Mutants: Priceless Tools to Develop Novel Therapies for Fabry Disease. [PDF]
Int J Mol Sci, 2021 Modrego A +5 more
europepmc +1 more source