Results 221 to 230 of about 90,634 (287)

Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human α-Galactosidase. [PDF]

JACS Au
Li HY, Lin HY, Chang SK, Chiu YT, Hou CC, Ko TP, Huang KF, Niu DM, Cheng WC.   +8 more
europepmc   +1 more source

Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and Humans

Aging Cell, Volume 25, Issue 3, March 2026.
Model showing decline in HKDC1 gene expression with aging. In a young cell, TFEB gets recruited to its binding sites on the HKDC1 promoter to upregulate HKDC1 expression, which interacts with mitochondria and stabilizes PINK1 to maintain mitochondrial health.
Zeenat Farooq, Vladimir Ilievski, James Boyett, Julianne Jorgensen, Yang Pan, Tanika Kelly, David Bennett, Orly Lazarov, Brian T. Layden   +8 more
wiley   +1 more source

Influence of diet nutrient density and a multicarbohydrase containing α-galactosidase on performance, carcass characteristics, breast myopathies, and nutrient utilization of broilers reared from 1 to 42 days of age. [PDF]

Poult Sci
Gulizia JP, Vargas JI, Bonilla SM, Hernandez JR, Almeida LM, Soster P, Thuekeaw S, Hutson B, Llamas-Moya S, Duong T, Pacheco WJ.   +10 more
europepmc   +1 more source

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice

Aging Cell, Volume 25, Issue 3, March 2026.
The left panel shows cerebral lactate homeostasis in young mice. The middle panel displays accelerated ANLS rates due to FGF21 secretion in aging mice. The right panel demonstrates that lactate uptake and usage inhibition contribute to lactate extracellular accumulation, followed by HCA1‐mediated learning and memory decline in mice.
Keru Ji, Hongde Wei, Ruguang Wang, Yutong Wu, Chen Li, Hongchang Gao, Liangcai Zhao   +6 more
wiley   +1 more source

Beyond nocardioform: Transcriptionally active microbes and host responses in equine mucoid placentitis

Equine Veterinary Journal, Volume 58, Issue 2, Page 601-618, March 2026.
Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule, Margo Verstraete, Jamie Kaj Norris, Kinga Barbara Graniczkowsa, Kirsten E. Scoggin, Hossam El‐Sheikh Ali, Barry A. Ball, Ward De Spiegelaere, Peter Daels, Bart C. Weimer, Pouya Dini   +10 more
wiley   +1 more source

Safety evaluation of the food enzyme α-galactosidase from the genetically modified <i>Saccharomyces cerevisiae</i> strain CBS 615.94. [PDF]

EFSA J
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Lambré C, Barat Baviera JM, Bolognesi C, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lampi E, Mengelers M, Mortensen A, Rivière G, Steffensen IL, Tlustos C, Van Loveren H, Vernis L, Zorn H, Roos Y, Aguilera J, Andryszkiewicz M, Kovalkovicova N, Liu Y, Marini E, Chesson A.   +24 more
europepmc   +1 more source

Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP‐1

Genes to Cells, Volume 31, Issue 2, March 2026.
Senescent fibroblasts construct collagen fibrils, whose orientation is disturbed. We found that senescent fibroblasts downregulate C‐pp cleavage enzymes BMP‐1 and PCPE‐1, which results in downregulation of C‐pp cleavage. This was demonstrated by conducting BMP‐1 knockdown experiments in young fibroblasts, which led to a disturbance in the orientation ...
Koji Moriya, Yuki Shibaike, Katsura Sano, Toshiaki Tanaka   +3 more
wiley   +1 more source

Purification and study of the kinetic properties of α-Galactosidase from coconut kernel

, 1982
K. Balasubramaniam, C. Deepal Mathew
openalex   +1 more source

Release of β-galactosidase from poloxamine/α-cyclodextrin hydrogels [PDF]

, 2014
César A Estévez, José Ramón Isasi, Eneko Larrañeta, Itziar Vélaz   +3 more
openalex   +1 more source

TaSPX3 Enhances Wheat Resistance to Leaf Rust by Antagonising TaDi19‐Mediated Repression of Pathogenesis‐Related Genes

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1031-1043, March 2026.
ABSTRACT Wheat leaf rust, caused by Puccinia triticina (Pt), threatens global wheat production, with yield losses further exacerbated by the pathogen's evolving virulence. Although Syg1/Pho81/Xpr1 (SPX) domain‐containing proteins are known regulators of phosphate homeostasis, their involvement in plant–pathogen interactions remains largely unexplored ...
Huimin Qian, Chuang Li, Yanan Lu, Xue Li, Jianping Zhang, Junyi Zhao, Keyan Wu, Yanyan Zhang, Kun Cheng, Daowen Wang, Pengyu Song, Na Liu, Wenming Zheng   +12 more
wiley   +1 more source