Results 11 to 20 of about 976,226 (308)
Marine Drugs, 2011 Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment.
Xiukun Lin +3 more
doaj +2 more sources
Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies [PDF]
, 2023 Diabetes mellitus remains a major global health burden and great attention is directed at natural therapeutics. This systematic review aimed to evaluate the potential of flavonoids as antidiabetic agents through their ability to inhibit α-amylase and α ...
Ngoc-Vi Nguyen, Tran +9 more
core +2 more sources
Foods, 2023 Hot-pressed peanut meal protein hydrolysates are rich in Arg residue, but there is a lack of research on their α-glucosidase inhibitory activity. In this study, different proteases were used to produce hot-pressed peanut meal protein hydrolysates (PMHs ...
Xinyu Yang +5 more
doaj +1 more source
Purification and characterization of two extracellular β-glucosidases fromAspergillus nidulans [PDF]
FEMS Microbiology Letters, 1992 Two β-glucosidases, P-I and P-II, were purified from the culture filtrate of Aspergillus nidulans. The Mr values of P-I and P-II were about 125 000 and 50 000, respectively. The isoelectric point, optimal pH and temperature, Michaelis constants for several substrates and inhibition constants for glucose and glucono-δ-lactone of each enzyme were ...
Ki-Sun Kwon +2 more
openaire +1 more source
In vitro α-glucosidase inhibitory activity of Tamarix nilotica shoot extracts and fractions.
PLoS ONE, 2022 α-glucosidase inhibitors represent an important class of type 2 antidiabetic drugs and they act by lowering postprandial hyperglycemia. Today, only three synthetic inhibitors exist on the market, and there is a need for novel, natural and more efficient ...
Mariane Daou +5 more
doaj +2 more sources
Inhibitory Mechanism of Engeletin Against α-Glucosidase
Natural Product Communications, 2021 The inhibitory mechanism of engeletin against α-glucosidase was investigated for the first time by fluorescence spectroscopy and molecular docking. The results showed that engeletin could inhibit α-glucosidase in a noncompetitive inhibition mode with a ...
Yunbo Li +4 more
doaj +1 more source
Extracellular α-glucosidase of an alkalophilic microorganism,Bacillussp. ATCC 21591 [PDF]
FEMS Microbiology Letters, 1983 Bacillus sp. ATCC 21591, an alkalophilic bacterium, produces 3 enzymes associated with degradation of starch-α-amylase, pullulanase and α-glucosidase. The latter reached a maximum after 24 h growth. Highest activities of α-glucosidase and pullulanase were obtained when the initial pH of the medium was 9.7 and although at pH 10.4 highest biomass was ...
C.T. Kelly, F. O'Reilly, W.M. Fogarty
openaire +1 more source
Cafestol analogues from Coffea canephora: in vitro inhibition and molecular docking to α-glucosidase
, 2022 A new cafestol-type diterpenoid, 5β-hydroxy-2-oxocafestol named coffecanepholide C (1) along with three known diterpenoids including cafestol (2), tricalysiolide A (3) and atractyligenin (4) were identified from the Coffea canephora trunks collected at ...
Thi Anh Tuyet Nguyen (9558826) +3 more
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in vitro.
Xu-Yang Deng +9 more
doaj +1 more source
Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel α-Glucosidase Inhibitor
Molecules, 2021 α-glucosidase is a major enzyme that is involved in starch digestion and type 2 diabetes mellitus. In this study, the inhibition of hypericin by α-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time ...
Qi Dong, Na Hu, Huilan Yue, Honglun Wang
doaj +1 more source