Results 1 to 10 of about 1,369,314 (252)

Benzonate derivatives of acetophenone as potent α-glucosidase inhibitors: synthesis, structure–activity relationship and mechanism

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
In this article, 23 compounds (6 and 7a–7v) were prepared and evaluated for their in vitro α-glucosidase inhibitory activity. The compounds 7d, 7f, 7i, 7n, 7o, 7r, 7s, 7u, and 7v displayed the α-glucosidase inhibition activity with IC50 values ranging ...
Wen-Jia Dan, Qiang Zhang, Fan Zhang, Wei-Wei Wang, Jin-Ming Gao   +4 more
doaj   +1 more source

Pneumatosis cystoides intestinalis of the ascending colon related to acarbose treatment: a case report

Journal of Medical Case Reports, 2009
Introduction Pneumatosis cystoides intestinalis is characterized by the presence of multiple gas-filled cysts in the intestinal wall, the submucosa and/or subserosa of the intestine.
Vogel Yilin, Buchner Nikolaus J, Szpakowski Michael, Tannapfel Andrea, Henning Bernhard F   +4 more
doaj   +1 more source

Activity guided discovery of dual inhibitors of α-glucosidase and β-glucuronidase from the leaves of Millettia pachycarpa Benth

Journal of Enzyme Inhibition and Medicinal Chemistry
Type 2 diabetes mellitus (T2DM) and cancers are two globally prevalent diseases which can increase the incidence of each other. Intestinal α-glucosidase and β-glucuronidase are key targets for glycaemic control and chemotherapy detoxification ...
Yanxi He, Huanran Xu, Shaoqian Tan, Jing Long, Hui Lei, Ling Xiao, Xiaoyi Qi, Mingming Deng, Xia Xiong, Jingcan You, Liangliang Zhu, Muhan Lü, Sicheng Liang   +12 more
doaj   +1 more source

Inhibitory Mechanism of Aloe Emodin on α-Glucosidase and Synergistic Effect with Acarbose [PDF]

Shipin Kexue
In order to investigate the interaction between aloe emodin and α-glucosidase, enzyme kinetics, ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy and fluorescence spectroscopy were employed to investigate the inhibitory mechanism of aloe emodin ...
QIN Chaofeng, LI Jiao, HAO Jingwen, BU Yaqin, LI Sheng, CHEN Naidong
doaj   +1 more source

Identification of Alkaloid-Derived α-Glucosidase Inhibitors for Diabetes Management: An In Silico Approach [PDF]

Journal of Advanced Biomedical Sciences
Background & Objectives: Alkaloids constitute a structurally diverse class of naturally occurring compounds with a wide range of pharmacological activities.
Mohsen Keshtmand, Morteza Sadeghi
doaj  

Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes. [PDF]

ACS Omega, 2023
Talab F, Ullah S, Alam A, Halim SA, Rehman NU, Zainab, Ali M, Latif A, Khan A, Al-Harrasi A, Ahmad M.   +10 more
europepmc   +1 more source

Combined Dipeptidyl Peptidase 4 Inhibitor and α-Glucosidase Inhibitor Treatment in Postprandial Hypoglycemia. [PDF]

Clin Diabetes, 2022
Broome DT, Kodali A, Phillips D, Makin V, Mendlovic D, Zimmerman RS.   +5 more
europepmc   +1 more source

Synthesis, Molecular Docking, and Bioactivity Study of Novel Hybrid Benzimidazole Urea Derivatives: A Promising α-Amylase and α-Glucosidase Inhibitor Candidate with Antioxidant Activity. [PDF]

Pharmaceutics, 2023
Aroua LM, Alosaimi AH, Alminderej FM, Messaoudi S, Mohammed HA, Almahmoud SA, Chigurupati S, Albadri AEAE, Mekni NH.   +8 more
europepmc   +1 more source

Screening of Dietary Flavonoids for Synergistic α-Glucosidase Inhibition with 1-Deoxynojirimycin and Elucidation of the Underlying Molecular Mechanism

Molecules
1-Deoxynojirimycin (DNJ), a well-characterized α-glucosidase inhibitor, remains an important target for dose-reduction and formulation strategies. In the present study, we evaluated the individual and combined α-glucosidase inhibitory activities of nine ...
Lin Wang, Jun Liu, Yonghong Zhao, Zhongshan Xiao, Lei Zeng, Zhuming Liu, Wei Wang, Baogang Wang, Jinping Wang   +8 more
doaj   +1 more source

Optimization of Extraction Process of Polysaccharides MAP-2 from Opuntia Milpa Alta by Response Surface Methodology and Evaluation of Its Potential as α-Glucosidase Inhibitor. [PDF]

Foods, 2022
Yang Y, Yang M, Zhou X, Chen H.
europepmc   +1 more source