Results 11 to 20 of about 18,318 (211)

Antioxidant and antidiabetic compounds identification in several Indonesian underutilized Zingiberaceae spices using SPME-GC/MS-based volatilomics and in silico methods

Food Chemistry: X, 2022
This study aimed to identify compounds in 12 minor Zingiberaceae spices grown in Indonesia linked with in vitro α-glucosidase inhibitor and antioxidant (DPPH, FRAP, CUPRAC) activities using SPME-GC/MS volatilomics.
Fitra Tunnisa, Didah Nur Faridah, Ani Afriyanti, Dian Rosalina, Mohamad Ana Syabana, Noviyan Darmawan, Nancy Dewi Yuliana   +6 more
doaj   +1 more source

TLC-MS Bioautography-Based Identification of Free-Radical Scavenging, α‑Amylase, and α‑Glucosidase Inhibitor Compounds of Antidiabetic Tablet BGR-34 [PDF]

ACS Omega, 2020
Gaurav, Sultan Zahiruddin, Bushra Parveen, Mohammad Ibrahim, Ikshit Sharma, Sanchit Sharma, Anil Kumar Sharma, Rabea Parveen, Sayeed Ahmad   +8 more
doaj   +2 more sources

Design, synthesis, in vitro, and in silico evaluations of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids as new antidiabetic agents targeting α-glucosidase

Scientific Reports, 2023
α-Glucosidase as a carbohydrate-hydrolase enzyme is a crucial therapeutic target for type 2 diabetes. In this work, benzo[d]imidazole-amide containing 1,2,3-triazole-N-arylacetamide derivatives 8a–n were synthesized and evaluated for their inhibitory ...
Faeze Yousefnejad, Mahyar Mohammadi-Moghadam-Goozali, Mohammad Hosein Sayahi, Mohammad Halimi, Ali Moazzam, Maryam Mohammadi-Khanaposhtani, Somayeh Mojtabavi, Mehdi Asadi, Mohammad Ali Faramarzi, Bagher Larijani, Massoud Amanlou, Mohammad Mahdavi   +11 more
doaj   +1 more source

FLAVONOIDS FROM RHYNCHOSIA PSEUDO-CAJAN AS SUITABLE α-GLUCOSIDASE INHIBITORS AND FREE RADICAL SCAVENGERS

International Research Journal of Pharmacy, 2014
A series of nine flavonoids , 1 - 9, isolated from Rhynchosia pseudo - cajan Cambe ss., ha s been investigated in present work for their biological potential against α - glucosidase, lipoxygenase (LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes ; and antioxidant activity against diphenylpicrylhydrazyl (DPPH) radica l ...
Muhammad Athar Abbasi, Ghulam Hussain, Aziz ur Rehman, Viqar Uddin Ahmad   +3 more
openaire   +1 more source

In Vitro Inhibition of α-Amylase and α-Glucosidase by Different Parts of Amla Plant (Phyllanthus emblica L) [PDF]

Pharmacology and Clinical Pharmacy Research, 2018
Amla plant (Phyllanthus emblica L) has been empirically used to treat diabetes. The aim of this study was to determine the most potential part of amla plant that can be used as α-glucosidase and α-amylase inhibitors.
Novi I. Fauzi, Maria Ulfah, Syarif Hamdani, Saeful Hidayat   +3 more
doaj   +1 more source

α-Glucosidase Inhibitory Activity of Fermented Okara Broth Started with the Strain Bacillus amyloliquefaciens SY07

Molecules, 2022
In this work, a new strain of Bacillus amyloliquefaciens SY07 isolated from a traditional fermented soybean food was reported to possess remarkable α-glucosidase inhibitor-producing ability. Different culture media were applied for the proliferation of B.
Yifang Gao, Wenhui Bian, Yuanyuan Fang, Peng Du, Xueting Liu, Xueru Zhao, Fengjuan Li   +6 more
doaj   +1 more source

Phytochemical profile, antioxidant activity, and inhibition of α-amylase and α-glucosidase for banana central pseudo-stem juice [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2021
The use of natural products to inhibit α-amylase and α-glucosidase is a strategy in the treatment of diabetes. This study investigated the phytochemical profile and antioxidant activity of, and α-amylase and α-glucosidase inhibition by banana central ...
Intira Koodkaew, Khwanruedee Chaiyawan, Pimchanok Satapoomin   +2 more
doaj   +1 more source

THE APPLICABILITY OF THE CRYSTAL STRUCTURE OF TERMOTOGA MARITIMA 4--GLUCANOTRANSFERASE AS THE TEMPLATE FOR SULOCHRIN AS -GLUCOSIDASE INHIBITORS

Indonesian Journal of Chemistry, 2010
Interaction of sulochrin to active site of glucosidase enzyme of Termotoga maritime has been studied by employing docking method using Molecular Operating Environment (MOE), in comparison with those are reports of established inhibitor α-glucosidase such
Rizna Triana Dewi, Yulia Anita, Enade Perdana Istyastono, Akhmad Darmawan, Muhamad Hanafi   +4 more
doaj   +1 more source

Design, synthesis, in vitro, and in silico biological evaluations of coumarin-indole hybrids as new anti-α-glucosidase agents

BMC Chemistry, 2022
Background A series of coumarin-indole hybrids was synthesized as the new α-glucosidase inhibitors. The title hybrids were considered as α-glucosidase inhibitors because had two active pharmacophores against α-glucosidase: coumarin and indole.
Davood Rezapour Niri, Mohammad Hosein Sayahi, Somayeh Behrouz, Ali Moazzam, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Hossein Rastegar, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi   +9 more
doaj   +1 more source

Synthesis of activity evaluation of flavonoid derivatives as ɑ-glucosidase inhibitors

Frontiers in Chemistry, 2022
Six flavonoid derivatives were synthesized and tested for anti-α-glucosidase activities. All derivatives were confirmed using NMR and HRMS and exhibited excellent inhibitory effects on α-glucosidase.
Hua Zhu, Xin Zhong
doaj   +1 more source