Results 21 to 30 of about 1,369,314 (252)

In Vitro Inhibition of α-Amylase and α-Glucosidase by Different Parts of Amla Plant (Phyllanthus emblica L) [PDF]

Pharmacology and Clinical Pharmacy Research, 2018
Amla plant (Phyllanthus emblica L) has been empirically used to treat diabetes. The aim of this study was to determine the most potential part of amla plant that can be used as α-glucosidase and α-amylase inhibitors.
Novi I. Fauzi, Maria Ulfah, Syarif Hamdani, Saeful Hidayat   +3 more
doaj   +3 more sources

α-Amylase and α-Glucosidase Inhibition by Brown Seaweed (Sargassum sp) Extracts

Research Journal of Life Science, 2014
Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to control post-prandial hyperglycemia associated with diabetes mellitus.
Muhammad Firdaus, Asep Awaludin Prihanto
doaj   +2 more sources

Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

Molecules, 2017
A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by 1H-NMR, 13C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity.
Zipeng Gong, Zhenzhen Xie, Jie Qiu, Guangcheng Wang   +3 more
doaj   +2 more sources

Docking Sulochrin and Its Derivative as α-Glucosidase Inhibitors of Saccharomyces cerevisiae [PDF]

Indonesian Journal of Chemistry, 2017
Sulochrin known has activity as inhibitors of α-glucosidase enzyme. Interaction of sulochrin to active site of α-glucosidase enzyme from S. cerevisiae has studied by docking method.
Wening Lestari, Rizna Triana Dewi, Leonardus Broto Sugeng Kardono, Arry Yanuar   +3 more
doaj   +2 more sources

Characterization of α-Glucosidase Inhibitor Streptomyces sp. IPBCC.a.29.1556 Aqueous Extract: An Endophyte of Indonesian Ficus deltoidea

Indonesian Journal of Chemistry, 2022
Filamentous bacteria have been known as actinobacteria which could produce various secondary metabolites, including an α-glucosidase inhibitor. The α-glucosidase inhibitor has been identified to be potentially valuable for the treatment of diabetes ...
Isra Janatiningrum, Yulin Lestari, Dedy Duryadi Solihin, Anja Meryandini   +3 more
doaj   +1 more source

Identification of highly potent α-glucosidase inhibitors from Garcinia schomburgkiana and molecular docking studies [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2021
Twenty-two compounds (1-22) were isolated from the stems and twigs of Garcinia schomburgkiana. NMR, IR, UV, and MS were used for structural elucidation, and comparisons were made with previous reports. Compound 1 exhibited the most potent α-glucosidase
Thi My Lien Do, Nguyen-Minh-An Tran, Thuc-Huy Duong, Preecha Phuwapraisirisan, Nakorn Niamnont, Kewalin Inthanon, Jirapast Sichaem, Suttira Sedlak   +7 more
doaj   +1 more source

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Natural Products and Bioprospecting, 2023
Diabetes mellitus remains a major global health burden and great attention is directed at natural therapeutics. This systematic review aimed to evaluate the potential of flavonoids as antidiabetic agents through their ability to inhibit α-amylase and α-glucosidase, two key starch digestive enzymes.
Thua-Phong Lam, Ngoc-Vi Nguyen Tran, Long-Hung Dinh Pham, Nghia Vo-Trong Lai, Bao-Tran Ngoc Dang, Ngoc-Lam Nguyen Truong, Song-Ky Nguyen-Vo, T Hoang, Tan Thanh, Thanh-Dao Tran   +9 more
openaire   +4 more sources

Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors

Molecules, 2022
A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor.
Haibo Wang, Senling Tang, Guoqing Zhang, Yang Pan, Wei Jiao, Huawu Shao   +5 more
doaj   +1 more source

Antioxidant and antidiabetic compounds identification in several Indonesian underutilized Zingiberaceae spices using SPME-GC/MS-based volatilomics and in silico methods

Food Chemistry: X, 2022
This study aimed to identify compounds in 12 minor Zingiberaceae spices grown in Indonesia linked with in vitro α-glucosidase inhibitor and antioxidant (DPPH, FRAP, CUPRAC) activities using SPME-GC/MS volatilomics.
Fitra Tunnisa, Didah Nur Faridah, Ani Afriyanti, Dian Rosalina, Mohamad Ana Syabana, Noviyan Darmawan, Nancy Dewi Yuliana   +6 more
doaj   +1 more source

Design, synthesis, in vitro, and in silico evaluations of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids as new antidiabetic agents targeting α-glucosidase

Scientific Reports, 2023
α-Glucosidase as a carbohydrate-hydrolase enzyme is a crucial therapeutic target for type 2 diabetes. In this work, benzo[d]imidazole-amide containing 1,2,3-triazole-N-arylacetamide derivatives 8a–n were synthesized and evaluated for their inhibitory ...
Faeze Yousefnejad, Mahyar Mohammadi-Moghadam-Goozali, Mohammad Hosein Sayahi, Mohammad Halimi, Ali Moazzam, Maryam Mohammadi-Khanaposhtani, Somayeh Mojtabavi, Mehdi Asadi, Mohammad Ali Faramarzi, Bagher Larijani, Massoud Amanlou, Mohammad Mahdavi   +11 more
doaj   +1 more source