Results 1 to 10 of about 2,753,652 (191)

Identification and Molecular Binding Mechanism of Novel α-Glucosidase Inhibitory Peptides from Hot-Pressed Peanut Meal Protein Hydrolysates

Foods, 2023
Hot-pressed peanut meal protein hydrolysates are rich in Arg residue, but there is a lack of research on their α-glucosidase inhibitory activity. In this study, different proteases were used to produce hot-pressed peanut meal protein hydrolysates (PMHs ...
Xinyu Yang, Dan Wang, Yangyong Dai, Luping Zhao, Wentao Wang, Xiuzhen Ding   +5 more
doaj   +2 more sources

A review on the in vitro and in vivo screening of α-glucosidase inhibitors

Heliyon
As a global metabolic disease, the control and treatment of diabetes have always been the focus of medical research. α-Glucosidase is a key enzyme in regulating blood glucose levels and has important applications in the treatment of diabetes. This review
Guangjuan Pan, Yantong Lu, Zhiying Wei, Yaohua Li, Li Li, Xiaojiao Pan   +5 more
doaj   +2 more sources

Advances in the natural α‐glucosidase inhibitors

eFood, 2023
α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels.
Didem Şöhretoğlu, Gülin Renda, Randolph Arroo, Jianbo Xiao, Suat Sari   +4 more
doaj   +1 more source

Screening and functional evaluation of the glucose-lowering active compounds of total saponins of Baibiandou (Lablab Semen Album)

Digital Chinese Medicine, 2021
Objective: To screen for α-glucosidase inhibitor active compounds in the total saponins of Baibiandou (Lablab Semen Album) based on UHPLC-Q-Exactive Orbitrap MS technology and to evaluate its hypoglycemic activity in vivo.
Jun Han, Qinfang Zheng, Liangzi Fang, Xiaolong Huang   +3 more
doaj   +1 more source

Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges.

European journal of medicinal chemistry, 2023
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st century. It is a well-recognized multifactorial health problem contributes significantly to high mortality rates by causing serious health complications mainly ...
A. Mushtaq, Uzma Azam, Saba Mehreen, Muhammad Moazzam Naseer   +3 more
semanticscholar   +1 more source

Design, synthesis, in vitro, and in silico biological evaluations of coumarin-indole hybrids as new anti-α-glucosidase agents

BMC Chemistry, 2022
Background A series of coumarin-indole hybrids was synthesized as the new α-glucosidase inhibitors. The title hybrids were considered as α-glucosidase inhibitors because had two active pharmacophores against α-glucosidase: coumarin and indole.
Davood Rezapour Niri, Mohammad Hosein Sayahi, Somayeh Behrouz, Ali Moazzam, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Hossein Rastegar, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi   +9 more
doaj   +1 more source

Synthesis and biological evaluation of indole derivatives containing thiazolidine-2,4-dione as α-glucosidase inhibitors with antidiabetic activity.

European journal of medicinal chemistry, 2023
In order to develop potential α-glucosidase inhibitors with antidiabetic activity, twenty-six indole derivatives containing thiazolidine-2,4-dione were synthesized.
Chunmei Hu, Bingwen Liang, Jinping Sun, Jiangyi Li, Zhuang Xiong, Shao-Hua Wang, Xue-Tao Xu   +6 more
semanticscholar   +1 more source

Synthesis of activity evaluation of flavonoid derivatives as ɑ-glucosidase inhibitors

Frontiers in Chemistry, 2022
Six flavonoid derivatives were synthesized and tested for anti-α-glucosidase activities. All derivatives were confirmed using NMR and HRMS and exhibited excellent inhibitory effects on α-glucosidase.
Hua Zhu, Xin Zhong
doaj   +1 more source

Enhanced enzymatic activity and stability by in situ entrapment of α-Glucosidase within super porous p(HEMA) cryogels during synthesis

Biotechnology Reports, 2020
Here, poly(2-hydroxyethyl methacrylate) (p(HEMA)) cryogel were prepared in the presence 0.48, 0.96, and 1.92 mL of α-Glucosidase enzyme (0.06 Units/mL) solutions to obtain enzyme entrapped superporous p(HEMA) cryogels, donated as α-Glucosidase@p(HEMA)-1,
Sahin Demirci, Mehtap Sahiner, Selehattin Yilmaz, Erdener Karadag, Nurettin Sahiner   +4 more
doaj   +1 more source

Identification of 1,3,4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity.

European journal of medicinal chemistry, 2023
In this study, we designed and synthesized a novel class of 1,3,4-oxadiazolyl-containing β-carboline derivatives, i.e., compounds f1∼f35 as potential α-glucosidase inhibitors.
Di Xiao, Li Lu, Bingwen Liang, Zhuang Xiong, Xue-Tao Xu, Wen-Hua Chen   +5 more
semanticscholar   +1 more source