Results 41 to 50 of about 1,767,652 (263)

Docking Sulochrin and Its Derivative as α-Glucosidase Inhibitors of Saccharomyces cerevisiae

Indonesian Journal of Chemistry, 2017
Sulochrin known has activity as inhibitors of α-glucosidase enzyme. Interaction of sulochrin to active site of α-glucosidase enzyme from S. cerevisiae has studied by docking method.
Wening Lestari, Rizna Triana Dewi, Leonardus Broto Sugeng Kardono, Arry Yanuar   +3 more
doaj   +1 more source

Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase

Pharmaceuticals, 2022
In this study, a stepwise reaction afforded thiazolidinone-based benzothiazole derivatives 1–15, and the synthesized derivatives were then screened for biological significance and found to be the leading candidates against α-amylase and α-glucosidase ...
Shoaib Khan, Shahid Iqbal, Marwa Khan, W. Rehman, Mazloom Shah, R. Hussain, Liaqat Rasheed, Y. Khan, A. Dera, R. Pashameah, Eman Alzahrani, Abd‐ElAziem Farouk   +11 more
semanticscholar   +1 more source

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

Biomolecules, 2021
Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors, and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α-amylase enzymes inhibitors can suppress peaks of postprandial glucose ...
Jirawat Riyaphan, Dinh-Chuong Pham, Max K. Leong, C. Weng   +3 more
semanticscholar   +1 more source

A method for in vivo evaluation of α-glucosidase inhibition using Drosophila

MethodsX, 2023
The development of α-glucosidase inhibitors is essential for the prevention of type II diabetes. Previous research has investigated in vitro inhibition using isolated α-glucosidase, which may not accurately reflect physical processes.
Nattapong Wongchum, Alongklod Tanomtong, Somchai Pinlaor, Chatmongkon Suwannapoom, Ananya Dechakhamphu   +4 more
doaj   +1 more source

Inhibitors of α‐amylase and α‐glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia

Food Science & Nutrition, 2020
The strategy of reducing carbohydrate digestibility by controlling the activity of two hydrolyzing enzymes (α‐amylase and α‐glucosidase) to control postprandial hyperglycemia is considered as a viable prophylactic treatment of type 2 diabetes mellitus ...
Lingxiao Gong, D. Feng, Tianxi Wang, Yuqing Ren, Yingli Liu, Jing Wang   +5 more
semanticscholar   +1 more source

THE APPLICABILITY OF THE CRYSTAL STRUCTURE OF TERMOTOGA MARITIMA 4--GLUCANOTRANSFERASE AS THE TEMPLATE FOR SULOCHRIN AS -GLUCOSIDASE INHIBITORS

Indonesian Journal of Chemistry, 2010
Interaction of sulochrin to active site of glucosidase enzyme of Termotoga maritime has been studied by employing docking method using Molecular Operating Environment (MOE), in comparison with those are reports of established inhibitor α-glucosidase such
Rizna Triana Dewi, Yulia Anita, Enade Perdana Istyastono, Akhmad Darmawan, Muhamad Hanafi   +4 more
doaj   +1 more source

Insight into the Inhibitory Mechanisms of Hesperidin on α-Glucosidase through Kinetics, Fluorescence Quenching, and Molecular Docking Studies

Foods, 2023
The α-glucosidase inhibitor is of interest to researchers due to its association with type-II diabetes treatment by suppressing postprandial hyperglycemia. Hesperidin is a major flavonoid in orange fruit with diverse biological properties.
Kumaravel Kaliaperumal, Linyan Zhang, Liangliang Gao, Qin Xiong, Yan Liang, Yueming Jiang, Jun Zhang   +6 more
doaj   +1 more source

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Food and Chemical Toxicology, 2020
Recently the use of bioactive α-glucosidase inhibitors for the treatment of diabetes have been proven to be the most efficient remedy for controlling postprandial hyperglycemia and its detrimental physiological complications, especially in type 2 ...
Uday Hossain, Abhishek Das, Sumit Ghosh, P. Sil   +3 more
semanticscholar   +1 more source

MOESM1 of Directed evolution of a fungal β-glucosidase in Saccharomyces cerevisiae

, 2016
Additional file 1. Table S1. Primers used in this study.
Larue, Kane, Melgar, Mindy, Martin, Vincent   +2 more
openaire   +1 more source

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies

Frontiers in Chemistry, 2022
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs showed a diverse range of activities having IC50 values between 0.80 ± 0.
Y. Khan, Shahid Iqbal, Mazloom Shah, A. Maalik, R. Hussain, Shoaib Khan, Imran H. Khan, R. Pashameah, Eman Alzahrani, Abd‐ElAziem Farouk, M. Alahmdi, H. S. Abd-Rabboh   +11 more
semanticscholar   +1 more source