Results 51 to 60 of about 1,799,019 (357)

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Natural Products and Bioprospecting
Diabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effects on α ...
Thua-Phong Lam, Ngoc V Tran, L. D. Pham, Nghia Vo-Trong Lai, Bao-Tran Ngoc Dang, Ngoc-Lam Nguyen Truong, Song-Ky Nguyen-Vo, T. Hoang, Tan Thanh Mai, T. Tran   +9 more
semanticscholar   +1 more source

Graminex pollen: phenolic pattern, colorimetric analysis and protective effects in immortalized prostate cells (PC3) and rat prostate challenged with LPS [PDF]

, 2018
Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents.
Brunetti, Luigi, Carradori, Simone, Cesa, Stefania, Chiavaroli, Annalisa, Ferrante, Claudio, Leone, Sheila, Leporini, Lidia, Locatelli, Marcello, Macchione, Nicola, Menghini, Luigi, Orlando, Giustino, Recinella, Lucia, Zengin, Gokhan   +12 more
core   +2 more sources

The small heat-shock proteins IbpA and IbpB reduce the stress load of recombinant and delay degradation of inclusion bodies [PDF]

, 2005
Background The permanently impaired protein folding during recombinant protein production resembles the stress encountered at extreme temperatures, under which condition the putative holding chaperones, IbpA/IbpB, play an important role. We evaluated the
Hoffmann Frank, Neubauer Peter, LeThanh Ha   +2 more
core   +1 more source

Honokiol as an α-glucosidase inhibitor

Frontiers in Pharmacology
Honokiol, a naturally occurring compound from Magnolia obovata Thunb., has many biological activities, but its anti-α-glucosidase activity is still unclear. Therefore, we determined its inhibitory effects against α-glucosidase.
Hua Zhu, Xin Zhong
doaj   +1 more source

Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats [PDF]

, 2015
In the present study, a 50% ethanolic extract of Orthosiphon stamineus was tested for its α-glucosidase inhibitory activity. In vivo assays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5,6,7,4′-tetramethoxyflavone, sinensetin, and ...
Ahmad, Mariam, Asmawi, Mohd. Zaini, Lee, Fung Ang, Mohamed, Elsnoussi Ali, Mun, Fei Yam   +4 more
core   +4 more sources

Synthesis and α-Glucosidase Inhibitory Mechanisms of Bis(2,3-dibromo-4,5-dihydroxybenzyl) Ether, a Potential Marine Bromophenol α-Glucosidase Inhibitor

Marine Drugs, 2011
Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment.
Xiukun Lin, Jianteng Wei, Wei Zhang, Ming Liu   +3 more
doaj   +1 more source

Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies

Journal of Enzyme Inhibition and Medicinal Chemistry
Inhibition of α-glucosidase and α-amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes.
Nirvana A. Gohar, E. Fayed, Yousry A. Ammar, Ola A Abu Ali, A. Ragab, A. Mahfoz, Moustafa S. Abusaif   +6 more
semanticscholar   +1 more source

Molecular Weight Dependent Glucose Lowering Effect of Low Molecular Weight Chitosan Oligosaccharide (GO2KA1) on Postprandial Blood Glucose Level in SD Rats Model [PDF]

, 2013
This research investigated the effect of enzymatically digested low molecular weight (MW) chitosan oligosaccharide on type 2 diabetes prevention. Three different chitosan oligosaccharide samples with varying MW were evaluated in vitro for inhibition of ...
Apostolidis, Emmanouil, Ha, Kyoung-Soo, Jo, Sung-Hoon, Kim, Jong-Gwan, Kim, Young-Cheul, Kwon, Young-In, Moon, Kyoung-Sik, Oh, Chen-Gum   +7 more
core   +3 more sources

Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study

Molecules, 2022
In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when compared to acarbose as a standard drug.
R. Hussain, S. Iqbal, Mazloom Shah, W. Rehman, Shoaib Khan, Liaqat Rasheed, F. Rahim, A. Dera, Sana Kehili, E. Elkaeed, N. Awwad, Majed A. Bajaber, M. Alahmdi, Hamad Alrbyawi, H. Alsaab   +14 more
semanticscholar   +1 more source

Bound Polyphenols from Red Quinoa Prevailed over Free Polyphenols in Reducing Postprandial Blood Glucose Rises by Inhibiting α-Glucosidase Activity and Starch Digestion

Nutrients, 2022
Inhibiting α-glucosidase activity is important in controlling postprandial hyperglycemia and, thus, helping to manage type-2 diabetes mellitus (T2DM). In the present study, free polyphenols (FPE) and bound polyphenols (BPE) were extracted from red quinoa
Yu Zhang, B. Bai, Yu Yan, J. Liang, Xiao-long Guan   +4 more
semanticscholar   +1 more source