Results 61 to 70 of about 1,767,652 (263)

FLAVONOIDS FROM RHYNCHOSIA PSEUDO-CAJAN AS SUITABLE α-GLUCOSIDASE INHIBITORS AND FREE RADICAL SCAVENGERS

International Research Journal of Pharmacy, 2014
A series of nine flavonoids , 1 - 9, isolated from Rhynchosia pseudo - cajan Cambe ss., ha s been investigated in present work for their biological potential against α - glucosidase, lipoxygenase (LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes ; and antioxidant activity against diphenylpicrylhydrazyl (DPPH) radica l ...
Muhammad Athar Abbasi, Ghulam Hussain, Aziz ur Rehman, Viqar Uddin Ahmad   +3 more
openaire   +1 more source

Selection and study of mutants ofDekkera intermediaandCandida wickerhamiiderepressed for β-glucosidase production [PDF]

FEMS Microbiology Letters, 1985
Mutants of Candida wickerhamii and Dekkera intermedia, derepressed for β-glucosidase biosynthesis, were isolated. These mutants were also shown to hyperproduce this enzyme. In anaerobic culture, the C. wickerhamii mutant still hyperproduced β-glucosidase and was derepressed. Glucose-cellobiose anaerobic fermentation by this strain was thus improved. On
Marc Leclerc, Bruno Blondin, Robert Ratomahenina, Alain Arnaud, Pierre Galzy   +4 more
openaire   +1 more source

Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies

Journal of Enzyme Inhibition and Medicinal Chemistry
Inhibition of α-glucosidase and α-amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes.
Nirvana A. Gohar, E. Fayed, Yousry A. Ammar, Ola A Abu Ali, A. Ragab, A. Mahfoz, Moustafa S. Abusaif   +6 more
semanticscholar   +1 more source

Antioxidant and Anti-α-Glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Fruits of Crataegus pinnatifida

Antioxidants, 2022
Crataegus pinnatifida is used to treat various diseases, including indigestion, congestive heart failure, hypertension, atherosclerosis, and myocardial dysfunction.
Yen-Ting Lin, Hsiang-Ru Lin, Chang-Syun Yang, Chia-Ching Liaw, P. Sung, Y. Kuo, M. Cheng, Jih-Jung Chen   +7 more
semanticscholar   +1 more source

Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG

Angewandte Chemie, EarlyView.
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R. Flavell, Michael A. Ohliger, Joanne Engel, Youngho Seo, David M. Wilson   +7 more
wiley   +2 more sources

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

and α-Glucosidase Inhibitory Activity of Perfoliatin a from

Natural Product Communications, 2019
As part of our effort to discover new α-glucosidase inhibitors from natural sources, it was found that an aqueous extract from Melampodium perfoliatum (Cavanilles) Kunth (Asteraceae) inhibited the activity of rat-intestinal α-glucosidases in a ...
Laura Flores-Bocanegra, Rafael Torres-Colín, Martin González-Andrade, José S. Calderón, Rachel Mata   +4 more
doaj   +1 more source

Synthesis and α-Glucosidase Inhibitory Mechanisms of Bis(2,3-dibromo-4,5-dihydroxybenzyl) Ether, a Potential Marine Bromophenol α-Glucosidase Inhibitor

Marine Drugs, 2011
Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment.
Xiukun Lin, Jianteng Wei, Wei Zhang, Ming Liu   +3 more
doaj   +1 more source

Partial purification and biochemical characterization of a soluble α-glucosidase II-like activity fromCandida albicans [PDF]

FEMS Microbiology Letters, 2004
A soluble α-glucosidase was partially purified from Candida albicans cells by a three-step procedure consisting of size-exclusion, ion-exchange and adsorption chromatographies. After the last step, enzyme was enriched about 8.7-fold with a yield of 13% over the starting material and analysis of the purified preparation revealed two major polypeptides ...
María Eugenia Torre-Bouscoulet, Everardo López-Romero, Rosalía Balcázar-Orozco, Carlos Calvo-Méndez, Arturo Flores-Carreón   +4 more
openaire   +1 more source