Results 21 to 30 of about 1,767,652 (263)
A constitutive, plasma-membrane bound β-glucosidase inTrichoderma reesei [PDF]
FEMS Microbiology Letters, 1986 Plasma membranes of Trichoderma reesei QM 9414, isolated from protoplasts by means of the concanavalin A procedure, contained β-glucosidase activity, which appeared constitutively upon growth on glucose. The enzyme had a pH optimum around 6, and was active on p-nitrophenyl-β-d-glucoside, cellobiose and sophorose (Km 0.7, 3.9 and 3.1 mM, respectively ...
Claudio Umile, Christian P. Kubicek
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European journal of medicinal chemistry, 2023 In this study, we designed and synthesized a novel class of 1,3,4-oxadiazolyl-containing β-carboline derivatives, i.e., compounds f1∼f35 as potential α-glucosidase inhibitors.
Di Xiao +5 more
semanticscholar +1 more source
Biotechnology Reports, 2020 Here, poly(2-hydroxyethyl methacrylate) (p(HEMA)) cryogel were prepared in the presence 0.48, 0.96, and 1.92 mL of α-Glucosidase enzyme (0.06 Units/mL) solutions to obtain enzyme entrapped superporous p(HEMA) cryogels, donated as α-Glucosidase@p(HEMA)-1,
Sahin Demirci +4 more
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Purification and characterization of two extracellular β-glucosidases fromAspergillus nidulans [PDF]
FEMS Microbiology Letters, 1992 Two β-glucosidases, P-I and P-II, were purified from the culture filtrate of Aspergillus nidulans. The Mr values of P-I and P-II were about 125 000 and 50 000, respectively. The isoelectric point, optimal pH and temperature, Michaelis constants for several substrates and inhibition constants for glucose and glucono-δ-lactone of each enzyme were ...
Ki-Sun Kwon +2 more
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In vitro α-glucosidase inhibitory activity of Tamarix nilotica shoot extracts and fractions.
PLoS ONE, 2022 α-glucosidase inhibitors represent an important class of type 2 antidiabetic drugs and they act by lowering postprandial hyperglycemia. Today, only three synthetic inhibitors exist on the market, and there is a need for novel, natural and more efficient ...
Mariane Daou +5 more
doaj +2 more sources
Inhibitory Mechanism of Engeletin Against α-Glucosidase
Natural Product Communications, 2021 The inhibitory mechanism of engeletin against α-glucosidase was investigated for the first time by fluorescence spectroscopy and molecular docking. The results showed that engeletin could inhibit α-glucosidase in a noncompetitive inhibition mode with a ...
Yunbo Li +4 more
doaj +1 more source
Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase
Life, 2022 It is well known that carbohydrates are the main source of calories in most diets. However, by inhibiting carbohydrases, intake of calories is reduced and weight loss is improved.
Ina Ćorković +4 more
semanticscholar +1 more source
Extracellular α-glucosidase of an alkalophilic microorganism,Bacillussp. ATCC 21591 [PDF]
FEMS Microbiology Letters, 1983 Bacillus sp. ATCC 21591, an alkalophilic bacterium, produces 3 enzymes associated with degradation of starch-α-amylase, pullulanase and α-glucosidase. The latter reached a maximum after 24 h growth. Highest activities of α-glucosidase and pullulanase were obtained when the initial pH of the medium was 9.7 and although at pH 10.4 highest biomass was ...
C.T. Kelly, F. O'Reilly, W.M. Fogarty
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International Journal of Molecular Sciences, 2023 Controlling post-prandial hyperglycemia and hyperlipidemia, particularly by regulating the activity of digestive enzymes, allows managing type 2 diabetes and obesity.
Quentin Haguet +11 more
semanticscholar +1 more source
Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel α-Glucosidase Inhibitor
Molecules, 2021 α-glucosidase is a major enzyme that is involved in starch digestion and type 2 diabetes mellitus. In this study, the inhibition of hypericin by α-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time ...
Qi Dong, Na Hu, Huilan Yue, Honglun Wang
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