Results 1 to 10 of about 89,329 (241)

Direct and indirect effects of PGF2α administration in male wistar rats based on increased expression of α-SMA and androgen receptor [PDF]

Open Veterinary Journal
Background: PGF2α hormone administration can improve semen quality through increased contractility of smooth muscle cells in testicular tissue and increased testosterone hormone.
Teuku Armansyah, Husnurrizal Husnurrizal, Sri Wahyuni, Hafizuddin Hafizuddin, Tongku Nizwan Siregar, Amalia Sutriana, Arman Sayuti, Adinda Tri Syahrani, Muhammad Bintang Pariansyah   +8 more
doaj   +2 more sources

Tumor and α‐SMA‐expressing stromal cells in pancreatic neuroendocrine tumors have a distinct RNA profile depending on tumor grade [PDF]

Molecular Oncology
Alpha‐smooth muscle actin (α‐SMA) expression in the stroma is linked to the presence of cancer‐associated fibroblasts and is known to correlate with worse outcomes in various tumors.
Helvijs Niedra, Raitis Peculis, Rihards Saksis, Ilona Mandrika, Sofija Vilisova, Jurijs Nazarovs, Austra Breiksa, Aija Gerina, Julie Earl, Ignacio Ruz‐Caracuel, Marta Gabriela Rosas, Aldis Pukitis, Natalja Senterjakova, Vita Rovite   +13 more
doaj   +2 more sources

Extracellular Volume Fraction Combined With Pathological Features of α‐SMA and FAP for Predicting the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma After Surgery and Evaluating the Efficacy of Chemotherapy [PDF]

Cancer Medicine
Objectives This study aimed to evaluate the extracellular matrix of pancreatic ductal adenocarcinoma (PDAC) using the extracellular volume fraction (fECV) derived from enhanced CT images, integrating fECV with α‐SMA‐positive cancer‐associated fibroblasts
Liqiang Liu, Sicheng Xu, Pengbiao Miao, Xing He, Yaorong Peng, Qixian Zhou, Junkai Ren, Zhenyu Zhou, Huilin Ye, Wenbin Li   +9 more
doaj   +2 more sources

Deciphering the stromal molecular landscape: the correlation between p16 and α-SMA in epithelial ovarian cancer [PDF]

Journal of Cancer Research and Clinical Oncology
Introduction The tumor microenvironment (TME) plays an essential role in promoting cancer initiation, progression and metastasis. Cancer-associated fibroblasts (CAFs) are a major constituent of the TME, but universal CAFs’ markers have not yet been ...
Marta Caretto, Angiolo Gadducci, Sabina Pistolesi, Diletta Mattiussi Tome, Giuseppe Nicolò Fanelli, Antonio Giuseppe Naccarato, Tommaso Simoncini   +6 more
doaj   +2 more sources

α-smooth muscle actin is not a marker of fibrogenic cell activity in skeletal muscle fibrosis. [PDF]

PLoS ONE, 2018
α-Smooth muscle actin (α-SMA) is used as a marker for a subset of activated fibrogenic cells, myofibroblasts, which are regarded as important effector cells of tissue fibrogenesis.
Wanming Zhao, Xingyu Wang, Kai-Hui Sun, Lan Zhou   +3 more
doaj   +1 more source

Comparison of expression of myofibroblasts in normal oral mucosa, oral epithelial dysplasia, and oral squamous cell carcinoma using α-SMA and vimentin: An immunohistochemical study

Journal of Family Medicine and Primary Care, 2020
Background: Myofibroblasts are thought to play critical roles in inflammation, growth, repair, premalignancy, and malignancy. This study was done to evaluate, compare and co- relate the progressive increase in the immunohistochemical expression of ...
Amani Mahajan, Andleeb Manhas, Tania Aneja, Swati Parhar, Priyanka Kumari, Anubhuti, Harkanwal P Singh   +6 more
doaj   +1 more source

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

Stem Cell Reports, 2015
Pro-fibrotic microenvironments of scars and tumors characterized by increased stiffness stimulate mesenchymal stromal cells (MSCs) to express α-smooth muscle actin (α-SMA).
Nilesh P. Talele, Julie Fradette, John E. Davies, Andras Kapus, Boris Hinz   +4 more
doaj   +1 more source

Alpha-smooth muscle actin-positive cancer-associated fibroblasts secreting osteopontin promote growth of luminal breast cancer

Cellular & Molecular Biology Letters, 2022
Background Cancer-associated fibroblasts (CAFs) have been shown to support tumor development in a variety of cancers. Different markers were applied to classify CAFs in order to elucidate their impact on tumor progression. However, the exact mechanism by
Anna Muchlińska, Anna Nagel, Marta Popęda, Jolanta Szade, Magdalena Niemira, Jacek Zieliński, Jarosław Skokowski, Natalia Bednarz-Knoll, Anna J. Żaczek   +8 more
doaj   +1 more source

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

eLife, 2018
Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect components of the contractile apparatus in capillary pericytes, most notably α-smooth muscle actin
Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan, Muge Yemisci, Jesse Schallek, Kıvılcım Kılıç, Alp Can, Adriana Di Polo, Turgay Dalkara   +7 more
doaj   +1 more source

Serological Assessment of Activated Fibroblasts by alpha-Smooth Muscle Actin (α-SMA): A Noninvasive Biomarker of Activated Fibroblasts in Lung Disorders

Translational Oncology, 2019
OBJECTIVES: Remodeling of the extracellular matrix (ECM) is a key event in different lung disorders, such as fibrosis and cancer. The most common cell type in the connective tissue is fibroblasts, which transdifferentiate into myofibroblasts upon ...
Signe Holm Nielsen, Nicholas Willumsen, Diana Julie Leeming, Samuel Joseph Daniels, Susanne Brix, Morten Asser Karsdal, Federica Genovese, Mette Juul Nielsen   +7 more
doaj   +1 more source