Results 1 to 10 of about 61,290 (162)
Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation
EBioMedicine, 2020 Background: Hypertrophic scar (HS) is characterized by the increased proliferation and decreased apoptosis of myofibroblasts. Myofibroblasts, the main effector cells for dermal fibrosis, develop from normal fibroblasts.
Guo-Zhong Lv +2 more
exaly +3 more sources
Tracing the origin of myofibroblasts in kidney fibrosis [PDF]
Nature CommunicationsKidney fibrosis is a key pathological feature of chronic kidney disease (CKD), characterized by the activation and accumulation of αSMA-positive myofibroblasts.
Shun He +9 more
doaj +2 more sources
The rise and fall of glucocorticoids and immunosuppressants in idiopathic pulmonary fibrosis: a historical paradigm shift driven by mechanistic understanding [PDF]
Frontiers in ImmunologyThe therapeutic strategy for Idiopathic Pulmonary Fibrosis (IPF) has undergone a fundamental transformation over recent decades. Combination therapy with glucocorticoids and immunosuppressants, particularly the “triple therapy” regimen including ...
Bing Wen +6 more
doaj +2 more sources
Corneal myofibroblasts and fibrosis
Experimental Eye Research, 2020 Myofibroblasts are alpha-smooth muscle actin (SMA)+ cells that have a critical role in the corneal stromal response to infections, injuries, and surgeries, and which produce corneal scarring fibrosis when they develop in excess. These contractile and opaque cells-produce large amounts of disordered extracellular matrix (ECM)-and develop from keratocyte-
Steven Wilson
exaly +4 more sources
Inflammatory myofibroblastic tumor
Contemporary Clinical Dentistry, 2011 Inflammatory myofibroblastic tumor is an uncommon lesion of unknown cause. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate.
Sangeeta Palaskar +3 more
doaj +3 more sources
Extracellular PKM2 facilitates organ-tissue fibrosis progression
iScience, 2021 Summary: Persistent activation of fibroblasts and resistance of myofibroblasts to turnover play important roles in organ-tissue fibrosis development and progression.
Hongwei Han +7 more
doaj +1 more source
The myofibroblast at a glance [PDF]
Journal of Cell Science, 2020 ABSTRACT In 1971, Gabbiani and co-workers discovered and characterized the “modification of fibroblasts into cells which are capable of an active spasm” (contraction) in rat wound granulation tissue and, accordingly, named these cells ‘myofibroblasts’.
Pardis Pakshir +7 more
openaire +2 more sources
Current Opinion in Rheumatology, 2013 Interest in the myofibroblast as a key player in propagation of chronic progressive fibrosis continues to elicit many publications, with focus on its cellular origins and the mechanisms underpinning their differentiation and/or transition. The objective of the review is to highlight this recent progress.The epithelial origin of the myofibroblast in ...
Biao, Hu, Sem H, Phan
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Myofibroblasts. II. Intestinal subepithelial myofibroblasts [PDF]
American Journal of Physiology-Cell Physiology, 1999 Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and proliferate in response to various growth factors, particularly the platelet-derived growth factor (PDGF) family, which includes PDGF-BB and stem cell factor ...
D W, Powell +5 more
openaire +2 more sources
Scientific Reports, 2021 Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described.
Giuseppina Abignano +5 more
doaj +1 more source