Results 1 to 10 of about 73,235 (299)

A two-way street – cellular metabolism and myofibroblast contraction [PDF]

npj Regenerative Medicine
Tissue fibrosis is characterised by the high-energy consumption associated with myofibroblast contraction. Although myofibroblast contraction relies on ATP production, the role of cellular metabolism in myofibroblast contraction has not yet been ...
Anne Noom, Birgit Sawitzki, Petra Knaus, Georg N. Duda   +3 more
doaj   +3 more sources

Generation and Characterization of an Immortalized Human Esophageal Myofibroblast Line. [PDF]

PLoS ONE, 2016
Stromal cells with a myofibroblast phenotype present in the normal human esophagus are increased in individuals with gastro-esophageal reflux disease (GERD).
Chao Niu, Uday Chauhan, Matthew Gargus, Anisa Shaker   +3 more
doaj   +2 more sources

Transcriptomic Study of Mechanism Driving Conjunctival Fibrosis Following Glaucoma Filtration Surgery. [PDF]

Biomedicines
Background: Glaucoma filtration surgery (GFS) is performed to slow down disease progression in glaucoma, a leading cause of irreversible blindness worldwide.
Pasvanis Z, Boynes A, Kong RCK, Chan EC, Wong RCB, Fan Gaskin J.   +5 more
europepmc   +2 more sources

The myofibroblast in wound healing and fibrosis: answered and unanswered questions [version 1; referees: 2 approved]

F1000Research, 2016
The discovery of the myofibroblast has allowed definition of the cell responsible for wound contraction and for the development of fibrotic changes.
Marie-Luce Bochaton-Piallat, Giulio Gabbiani, Boris Hinz   +2 more
doaj   +2 more sources

PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice

The Journal of Clinical Investigation
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the excessive accumulation of activated myofibroblasts that deposit extracellular matrix (ECM) protein, leading to progressive scar formation and mechanical ...
Liran Xu, Ting Li, Yapeng Cao, Yu He, Zehua Shao, Siyu Liu, Bianbian Wang, Ailing Su, Huijing Tian, Yongxin Li, Guozheng Liang, Changhe Wang, John Shyy, Ying Xiong, Fangyuan Chen, Jason X.J. Yuan, Junjun Liu, Bin Zhou, Nina Wettschureck, Stefan Offermanns, Yang Yan, Zuyi Yuan, Shengpeng Wang   +22 more
doaj   +2 more sources

Splicing isoforms associated with TGFβ-induced myofibroblast activation. [PDF]

BMC Mol Cell Biol
Background Myofibroblast differentiation is a key process in developmental biology and involved in numerous physiopathology. The gene expression program orchestrating fibroblast to myofibroblast differentiation, as well as its recapitulation by TGFβ ...
Alli-Oke O, Bergeron D, Kessai F, Thibault P, Durand M, Brosseau JP.   +5 more
europepmc   +2 more sources

The myofibroblast at a glance [PDF]

Journal of Cell Science, 2020
ABSTRACT In 1971, Gabbiani and co-workers discovered and characterized the “modification of fibroblasts into cells which are capable of an active spasm” (contraction) in rat wound granulation tissue and, accordingly, named these cells ‘myofibroblasts’.
Pardis Pakshir, Nina Noskovicova, Monika Lodyga, Dong Ok Son, Ronen Schuster, Amanda Goodwin, Henna Karvonen, Boris Hinz   +7 more
openaire   +2 more sources

Fibrotic Remodeling during Persistent Atrial Fibrillation: In Silico Investigation of the Role of Calcium for Human Atrial Myofibroblast Electrophysiology

Cells, 2021
During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different scales from the molecular level to the tissue level. One central player that contributes to both electrical and structural remodeling is the myofibroblast ...
Jorge Sánchez, Beatriz Trenor, Javier Saiz, Olaf Dössel, Axel Loewe   +4 more
doaj   +1 more source

Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis

Journal of Translational Medicine, 2023
Background Silica-induced pulmonary fibrosis (silicosis) is a diffuse interstitial fibrotic disease characterized by the massive deposition of extracellular matrix in lung tissue.
Yaqian Qu, Ruonan Zhai, Dandan Wang, Zheng Wang, Guangjie Hou, Chenchen Wu, Meian Tang, Xiongbin Xiao, Jie Jiao, Yue Ba, Fang Zhou, Jian Qiu, Wu Yao   +12 more
doaj   +1 more source

Myofibroblasts [PDF]

Current Opinion in Rheumatology, 2013
Interest in the myofibroblast as a key player in propagation of chronic progressive fibrosis continues to elicit many publications, with focus on its cellular origins and the mechanisms underpinning their differentiation and/or transition. The objective of the review is to highlight this recent progress.The epithelial origin of the myofibroblast in ...
Biao, Hu, Sem H, Phan
openaire   +2 more sources