Results 21 to 30 of about 73,235 (299)

The Myofibroblasts’ War on Drugs [PDF]

Developmental Cell, 2018
The intestinal lining faces a constant assault from harmful gut contents. A study by Chee and colleagues in this issue of Developmental Cell describes how a population of myofibroblasts resists these threats and boosts regeneration of the intestinal epithelium.
Puschhof, Jens, Clevers, Hans
openaire   +3 more sources

Editorial: Liver Myofibroblasts [PDF]

Frontiers in Physiology, 2016
Myofibroblasts (MFB) were first identified in the granulation tissue of healing wounds. They have features of both fibroblasts and smooth muscle cells. In contrast to fibroblasts they contain cytoplasmic actin microfilaments (stress fibers) connected to the extracellular matrix (ECM) by focal contacts.
Kanta, Jiri, Mrkvicová, Alena, Weiskirchen, Ralf   +2 more
openaire   +3 more sources

Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth

Scientific Reports, 2018
We have previously shown myofibroblasts subjacent to the squamous epithelium in the normal human esophagus and an increase in esophagitis. Myofibroblast contribution to bone morphogenetic protein (BMP) signaling and to paracrine mediated epithelial ...
Chunying Zhang, Chao Niu, Kevin Yang, Anisa Shaker   +3 more
doaj   +1 more source

Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway

Respiratory Research, 2023
Background Idiopathic pulmonary fibrosis (IPF) is a chronically progressive fibrotic pulmonary disease characterized by an uncertain etiology, a poor prognosis, and a paucity of efficacious treatment options.
Xiaofan Lai, Yingying Lin, Shaojie Huang, Lvya Pu, Qihao Zeng, Zhongxing Wang, Wenqi Huang   +6 more
doaj   +1 more source

PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction

JACC: Basic to Translational Science, 2023
Summary: After myocardial infarction (MI), fibroblasts progress from proliferative to myofibroblast states, resulting in fibrosis. Platelet-derived growth factors (PDGFs) are reported to induce fibroblast proliferation, myofibroblast differentiation, and
Robert D. Hume, PhD, Tejas Deshmukh, MBBS, MClinTR, Tram Doan, PhD, Woo Jun Shim, PhD, Shaan Kanagalingam, BSc, Vikram Tallapragada, PhD, Fairooj Rashid, MSc, Maria Marcuello, PhD, Daniel Blessing, PhD, Dinesh Selvakumar, MBBS, Kalyan Raguram, BMed, Faraz Pathan, MBBS, PhD, Dinny Graham, PhD, Samir Ounzain, PhD, Eddy Kizana, PhD, Richard P. Harvey, PhD, Nathan J. Palpant, PhD, James J.H. Chong, MBBS, PhD   +17 more
doaj   +1 more source

A new antifibrotic target of Ac-SDKP: inhibition of myofibroblast differentiation in rat lung with silicosis.

PLoS ONE, 2012
BackgroundMyofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, is a key process in organ fibrosis, and is induced by TGF-β.
Hong Xu, Fang Yang, Ying Sun, Yuan Yuan, Hua Cheng, Zhongqiu Wei, Shuyu Li, Tan Cheng, Darrell Brann, Ruimin Wang   +9 more
doaj   +1 more source

Recovery of Altered Diabetic Myofibroblast Heterogeneity and Gene Expression Are Associated with CD301b+ Macrophages

Biomedicines, 2021
Diabetic wound healing is associated with impaired function and reduced numbers of myofibroblasts, a heterogeneous cell population with varying capacities to promote repair.
MaryEllen R. Haas, Darlene V. Nguyen, Brett A. Shook   +2 more
doaj   +1 more source

miR-21 promotes the fibrotic properties in oral mucosa through targeting PDCD4

Journal of Dental Sciences, 2022
Background/purpose: Oral submucous fibrosis (OSF) has been regarded as a premalignant disorder of oral cancer, and myofibroblasts are the main cells that are responsible for pathological fibrosis.
Yi-Wen Liao, Lo-Lin Tsai, Yu-Hsien Lee, Pei-Ling Hsieh, Cheng-Chia Yu, Ming-Yi Lu   +5 more
doaj   +1 more source

Topical rosiglitazone is an effective anti-scarring agent in the cornea [PDF]

, 2013
Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome ...
Phipps, Richard P., Holly B Hindman, MacRae, Scott, Patricia J Sime, Krystel R Huxlin, David Ciufo, Jeon, Kye-Im, Richard P Phipps, Sime, Patricia J., DeMagistris, Margaret, Ciufo, David, Huxlin, Krystel R., Jens Bühren, Scott MacRae, Kye-Im Jeon, Margaret DeMagistris, Bühren, Jens, Hindman, Holly B.   +17 more
core   +2 more sources

Recent developments in myofibroblast biology paradigms for connective tissue remodeling [PDF]

, 2012
The discovery of the myofibroblast has opened new perspectives for the comprehension of the biological mechanisms involved in wound healing and fibrotic diseases.
Phan, Sem H, Hinz, Boris, Prunotto, Marco, Desmouliere, Alexis, Phan, Sem H., Thannickal, Victor J, Gabbiani, Giulio, Varga, John, Mareel, Marcus, Gabbian, Giulio, De Wever, Olivier, Mareel, Marc, Thannickal, Victor J.   +12 more
core   +1 more source