Results 31 to 40 of about 73,235 (299)

Identification and characterization of two isoforms of human megakaryoblastic Leukemia-1 and their specific regulation in myofibroblast differentiation [PDF]

, 2013
The reversible differentiation of various precursor cell types into myofibroblasts/cancer-associated fibroblasts (CAFs) is an important physiological as well as pathological process.
Scharenberg, Matthias
core   +1 more source

Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress

JACC: Basic to Translational Science
Summary: Cardiac fibrosis can be mitigated by limiting fibroblast-to-myofibroblast differentiation and proliferation. Human antigen R (HuR) modulates messenger RNA stability and expression of multiple genes.
Mallikarjun Patil, PhD, Sarojini Singh, PhD, Praveen Kumar Dubey, PhD, Sultan Tousif, PhD, Prachi Umbarkar, PhD, Qinkun Zhang, MD, Hind Lal, PhD, Mary Kathryn Sewell-Loftin, PhD, Channakeshava Sokke Umeshappa, PhD, Yohannes T. Ghebre, PhD, Steven Pogwizd, MD, Jianyi Zhang, MD, PhD, Prasanna Krishnamurthy, PhD   +12 more
doaj   +1 more source

Pleiotropic Long-Term Effects of Atorvastatin on Posttraumatic Joint Contracture in a Rat Model

Pharmaceutics, 2022
The antifibrotic effect of atorvastatin has already been demonstrated in several organ systems. In the present study, a rat model was used to investigate the effect of atorvastatin on posttraumatic joint contracture.
Erik Wegner, Ekaterina Slotina, Tim Mickan, Sebastian Truffel, Charlotte Arand, Daniel Wagner, Ulrike Ritz, Pol M. Rommens, Erol Gercek, Philipp Drees, Andreas Baranowski   +10 more
doaj   +1 more source

Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair

, 2012
The matricellular protein periostin is expressed in the skin. Although periostin has been hypothesized to contribute to dermal homeostasis and repair, this has not been directly tested. To assess the contribution of periostin to dermal healing, 6 mm full-
Guan, J., Eastwood, M., Leask, A., Conway, S.J., Guo, X., Elliott, C.G., Wang, J., Xu, S.W., Hamilton, D.W., Shi-Wen, X.   +9 more
core   +1 more source

Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of α-smooth muscle actin containing stress fibers [PDF]

, 2011
Rationale: Myofibroblasts typically appear in the myocardium after insults to the heart like mechanical overload and infarction. Apart from contributing to fibrotic remodeling, myofibroblasts induce arrhythmogenic slow conduction and ectopic activity in ...
Nicolò Salvarani, Schmutz, Stephan, Grand, Teddy, Rohr, Stephan, Rosker, Christian, Teddy Grand, Stephan Schmutz, Stephan Rohr, Salvarani, Nicolò, Christian Rosker   +9 more
core   +2 more sources

Coordination of Myofibroblast Contraction in Vitro [PDF]

, 2010
The aim of this thesis is to elucidate the common mechanisms that regulate myofibroblast contraction and intercellular communication, with a particular focus on the role of Ca2+ signalling.
Follonier Castella, Lysianne
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Multicentric myofibroblastic sarcoma [PDF]

BMJ Case Reports, 2014
We report a case of synchronous, multicentric low-grade myofibroblastic sarcoma presenting in a 62-year-old man. He initially presented with inflammatory symmetric polyarthritis and adhesive capsulitis of his shoulder and hips bilaterally and did not respond to a trial of disease modifying antirheumatic drugs.
Mihir Dilip, Wechalekar, Oliver, Ayres, Gelareh, Farshid, Mark, Clayer, Leslie G, Cleland   +4 more
openaire   +2 more sources

Tissue repair, contraction, and the myofibroblast

, 2005
After the first description of the myofibroblast in granulation tissue of an open wound by means of electron microscopy, as an intermediate cell between the fibroblast and the smooth muscle cell, the myofibroblast has been identified both in normal ...
Desmouliere, Alexis, Chaponnier, Christine, Gabbiani, Giulio   +2 more
core   +1 more source

Facial Cosmetic Therapy Use Among Patients With Systemic Sclerosis: An Australian Cohort Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is associated with numerous facial manifestations for which patients may engage in cosmetic therapies. It is unclear how patients with SSc use these therapies. This study sought to characterize patient engagement and experiences with cosmetic therapies for SSc‐related and non‐SSc–related facial changes.
Zachary Warren, Diane Apostolopoulos, Gene‐Siew Ngian, Amanda M. Saracino, Laura Ross, Nava Ferdowsi, Jennifer Walker, Cindy Hall, Kim Griggs, Susanna Proudman, Wendy Stevens, Joanne Sahhar   +11 more
wiley   +1 more source