Results 51 to 60 of about 73,235 (299)

Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis

Frontiers in Cardiovascular Medicine, 2022
BackgroundActivated cardiac fibroblasts (CF) play a central role in cardiac fibrosis, a condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury.
Maria Raquel Moita, Maria Raquel Moita, Marta M. Silva, Cláudia Diniz, Cláudia Diniz, Margarida Serra, Margarida Serra, René M. Hoet, Ana Barbas, Daniel Simão   +9 more
doaj   +1 more source

The biology of the myofibroblast

Kidney International, 1992
The mechanisms leading to the retraction of the granulation tissue during wound healing have not been fully elucidated to date [reviewed in 1]. Our laboratory several years ago described that fibroblasts present in granulation tissue exhibit several ultrastructural features of smooth muscle cells, including the presence of microfilament bundles with ...
openaire   +3 more sources

Mechanical aspects of lung fibrosis: a spotlight on the myofibroblast [PDF]

, 2012
Reprinted with permission of the American Thoracic Society. Copyright © 2015 American Thoracic Society. Cite: Hinz B. Mechanical aspects of lung fibrosis: a spotlight on the myofibroblast. Proc Am Thorac Soc. 2012 Jul;9(3):137-47.
Hinz, Boris
core   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

MYOFIBROBLAST MECHANICS

, 2017
Tissues lose integrity upon injury. To rapidly restore mechanical stability, a variety of different cell types are activated to acquire a reparative phenotype - the myofibroblast. Hallmarks of the myofibroblast are secretion of extracellular matrix (ECM),
Hinz, Boris
core   +1 more source

CD8+ T cells drive myofibroblast activation and contraction via JAK/STAT3 and TGFβ signaling

iScience
Summary: Fibrosis in rheumatic connective tissue diseases is marked by CD8+ T cell and pro-fibrotic myofibroblast infiltration, though the role of CD8+ T cells in myofibroblast activity remains unexplored.
Theodoros Ioannis Papadimitriou, Anne van Essen, Merel Willemse, Daphne Dorst, Elly Vitters, Birgitte Walgreen, Hans J.P.M. Koenen, Peter van der Kraan, Marije Koenders, Rogier M. Thurlings, Arjan van Caam   +10 more
doaj   +1 more source

Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts

Cardiology Journal, 2020
BACKGROUND: Cardiac fibroblasts (CFs) are principal extracellular matrix-producing cells. In response to injury, CFs transdifferentiate into myofibroblasts. Intracellular calcium (Ca2+) signaling, involved in fibroblast proliferation and differentiation,
Min-Soo Ahn, Young Woo Eom, Ji-Eun Oh, Seung-Kuy Cha, Kyu Sang Park, Jung-Woo Son, Jun-Won Lee, Young Jin Youn, Sung Gyun Ahn, Jang-Young Kim, Seung-Hwan Lee, Junghan Yoon, Byung-Su Yoo   +12 more
doaj   +1 more source

Macromolecular Crowding as a Tool to Screen Anti-fibrotic Drugs: The Scar-in-a-Jar System Revisited

Frontiers in Medicine, 2021
An unsolved therapeutic problem in fibrosis is the overproduction of collagen. In order to screen the effect of anti-fibrotic drugs on collagen deposition, the Scar-in-a-Jar approach has been introduced about a decade ago.
Nataly Puerta Cavanzo, Nataly Puerta Cavanzo, Emilia Bigaeva, Miriam Boersema, Peter Olinga, Ruud A. Bank   +5 more
doaj   +1 more source

Zeb2: A novel regulator of cardiac fibroblast to myofibroblast transition [PDF]

, 2014
Cardiac fibroblast to myofibroblast phenoconversion is a critical step during the development of cardiac fibrosis. Myofibroblasts chronically remodel extracellular matrix that results in myocardial stiffening, cardiac dysfunction and eventually heart ...
Jahan, Fahmida
core  

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source