Results 11 to 20 of about 73,235 (299)

Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation

iScience, 2023
Summary: Pulmonary fibrosis (PF) is a fatal and irreversible respiratory disease accompanied by excessive fibroblast activation. Previous studies have suggested that cAMP signaling pathway and cGMP-PKG signaling pathway are continuously down-regulated in
Ya-Jun Li, Jian-Rong Shi, Shu-Chan Li, Lu-Ming Wang, Rana Dhar, Ning Li, Xin-Wei Cao, Zi-Gang Li, Hui-Fang Tang   +8 more
doaj   +1 more source

Myofibroblasts. II. Intestinal subepithelial myofibroblasts [PDF]

American Journal of Physiology-Cell Physiology, 1999
Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and proliferate in response to various growth factors, particularly the platelet-derived growth factor (PDGF) family, which includes PDGF-BB and stem cell factor ...
D W, Powell, R C, Mifflin, J D, Valentich, S E, Crowe, J I, Saada, A B, West   +5 more
openaire   +2 more sources

Comparative Analysis of Co-Cultured Amniotic Cell-Conditioned Media with Cell-Free Amniotic Fluid Reveals Differential Effects on Epithelial–Mesenchymal Transition and Myofibroblast Activation

Biomedicines, 2022
Myofibroblast activation is a cellular response elicited by a variety of physiological or pathological insults whereby cells initiate a coordinated response intended to eradicate the insult and then revert back to a basal state.
Naiyou Liu, Charles M. Bowen, Mohammadali M. Shoja, Karen Larissa Castro de Pereira, Laxmi Priya Dongur, Antonio Saad, William K. Russell, Thomas Christopher Broderick, Jeffrey H. Fair, William Samuel Fagg   +9 more
doaj   +1 more source

Hyaluronidase-2 regulates RhoA signalling, myofibroblast contractility and other key pro-fibrotic myofibroblast functions [PDF]

, 2020
Hyaluronidase-2 (HYAL2) is a weak, acid-active hyaluronan-degrading enzyme that is broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology.
Hascall, Vincent, Meran, Soma, Midgley, Adam C., Brown, Charlotte, Chavez, Rafael, Steadman, Robert, Jenkins, Robert, Phillips, Aled O., Khalid, Usman, Woods, Emma   +9 more
core   +1 more source

TRPV1 potentiates TGFβ-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop. [PDF]

PLoS ONE, 2013
Injuring mouse corneas with alkali causes myofibroblast expression leading to tissue opacification. However, in transient receptor potential vanilloid 1 channel (TRPV1-/-) knockout mice healing results in transparency restoration.
Yuanquan Yang, Zheng Wang, Hua Yang, Lingyan Wang, Stephanie R Gillespie, J Mario Wolosin, Audrey M Bernstein, Peter S Reinach   +7 more
doaj   +1 more source

Transgelin as a regulator of myofibroblast differentiation in fibrosis

, 2023
Parreno, JustinCellular differentiation into highly contractile myofibroblasts is a major underlying cause of morbidity in fibrotic diseases. The cells responsible for fibrosis progression are myofibroblasts.
Emin, Grace Marie
core   +1 more source

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts

Cells, 2020
We identify the focal adhesion protein kindlin-2 as player in a novel mechanotransduction pathway that controls profibrotic cardiac fibroblast to myofibroblast activation. Kindlin-2 is co-upregulated with the myofibroblast marker α-smooth muscle actin (α-
Elena Godbout, Dong Ok Son, Stephanie Hume, Stellar Boo, Vincent Sarrazy, Sophie Clément, Andras Kapus, Bernhard Wehrle-Haller, Leena Bruckner-Tuderman, Cristina Has, Boris Hinz   +10 more
doaj   +1 more source

The Myofibroblast [PDF]

The American Journal of Pathology, 2007
The crucial role played by the myofibroblast in wound healing and pathological organ remodeling is well established; the general mechanisms of extracellular matrix synthesis and of tension production by this cell have been amply clarified. This review discusses the pattern of myofibroblast accumulation and fibrosis evolution during lung and liver ...
HINZ B, PHAM SH, THANNICKAL VJ, GALLI, ANDREA, BOCHATON PIALLAT, GABBIANI G.   +5 more
openaire   +5 more sources

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Ayuko Takahashi (789901), Barbara D. Smith (2212672), Takahashi, A, Christopher Denton, Layne, MD, Bahja Ahmed-Abdi, Ayuko Takahashi, Suki, B, Nikitorowicz-Buniak, J, Bela Suki (2212681), Bahja Ahmed-Abdi (2212675), Matthew D. Layne (364786), Markella Ponticos, Ahmed-Abdi, B, Robert Lafyatis, Markella Ponticos (2212669), Xu Shiwen (2212678), Stratton, R, Bela Suki, Barbara D Smith, Richard Stratton (776213), Joanna Nikitorowicz-Buniak (776212), Smith, BD, Christopher Denton (276245), Xu Shiwen, Lafyatis, R, David Abraham (36404), Shiwen, X, David Abraham, Abraham, D, Matthew D Layne, Ponticos, M, Denton, C, Joanna Nikitorowicz-Buniak, Robert Lafyatis (38139), Richard Stratton   +35 more
core   +1 more source

Optogenetic current in myofibroblasts acutely alters electrophysiology and conduction of co-cultured cardiomyocytes

Scientific Reports, 2021
Interactions between cardiac myofibroblasts and myocytes may slow conduction and generate spontaneous beating in fibrosis, increasing the chance of life-threatening arrhythmia.
Geran M. Kostecki, Yu Shi, Christopher S. Chen, Daniel H. Reich, Emilia Entcheva, Leslie Tung   +5 more
doaj   +1 more source