Results 21 to 30 of about 61,389 (261)
Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions
JCI Insight, 2021 Myofibroblasts are the major cellular source of collagen, and their accumulation — via differentiation from fibroblasts and resistance to apoptosis — is a hallmark of tissue fibrosis.
Sean M. Fortier +5 more
doaj +1 more source
Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts
Frontiers in Physiology, 2015 Myofibroblasts play important roles in inflammation, fibrosis and tumorigenesis in chronically inflamed liver. Liver myofibroblasts originate from hepatic stellate cells, portal fibroblasts or mesothelial cells, and they are localized in and around ...
Norifumi eKawada
doaj +1 more source
Biomolecules, 2022 Mesenchymal cells (keratocytes, corneal fibroblasts, and myofibroblasts), as well as mesenchymal progenitor bone marrow-derived fibrocytes, are the major cellular contributors to stromal fibrosis after injury to the cornea.
Steven E. Wilson
doaj +1 more source
Hyaluronidase pharmacological properties and clinical application in ophthalmology
Сибирский научный медицинский журнал, 2020 Corneal diseases are the fourth leading cause of blindness in the world, accounting for approximately 5 % of cases. Existing methods of treatment in more than 30 % of cases do not have a full therapeutic effect and when the process is stopped, they end ...
V. E. Zabanova +2 more
doaj +1 more source
Giant Intramuscular Nodular Fasciitis Masquerading as Soft Tissue Sarcoma with Neural Involvement - A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2016 Nodular Fasciitis (NF) is described as a benign reactive proliferation of myofibroblasts that occurs predominantly in the subcutaneous location. Most commonly presents as rapidly growing swelling in the young adults, with usual size of less than 4cm and
Anandhi Amaranathan +3 more
doaj +1 more source
Applied Sciences, 2021 The aim was to determine the cytotoxicity of Khat (Catha edulis (Vahl) Forssk. ex Endl) on normal oral fibroblasts (NOFs) and SCC4 (squamous carcinoma cells) along with expression of α-smooth muscle actin (α-SMA) in fibroblasts.
Azeem Ul Yaqin Syed +10 more
doaj +1 more source
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies.
Frontiers in Pharmacology, 2014 Liver fibrosis results from dysregulation of normal wound healing, inflammation, activation of myofibroblasts and deposition of extracellular matrix (ECM). Chronic liver injury causes death of hepatocytes and formation of apoptotic bodies, which in turn,
Jun eXu +8 more
doaj +1 more source
Role of Fibroblasts and Myofibroblasts on the Pathogenesis and Treatment of Pelvic Organ Prolapse
Biomolecules, 2022 Pelvic organ prolapse (POP) is a multifactorial connective tissue disorder caused by damage to the supportive structures of the pelvic floor, leading to the descent of pelvic organs in the vagina.
Zeliha Guler, Jan Paul Roovers
doaj +1 more source
eLife, 2018 Pdgfra-expressing (Pdgfra+) cells have been implicated as progenitors in many mesenchymal tissues. To determine lineage potential, we generated PdgfrartTA knockin mice using CRISPR/Cas9.
Rongbo Li +5 more
doaj +1 more source
Fibrocytes: A Critical Review and Practical Guide
Frontiers in Immunology, 2021 Fibrocytes are hematopoietic-derived cells that directly contribute to tissue fibrosis by producing collagen following injury, during disease, and with aging.
James W. Reinhardt +3 more
doaj +1 more source