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Current Opinion in Rheumatology, 2013 Interest in the myofibroblast as a key player in propagation of chronic progressive fibrosis continues to elicit many publications, with focus on its cellular origins and the mechanisms underpinning their differentiation and/or transition. The objective of the review is to highlight this recent progress.The epithelial origin of the myofibroblast in ...
Biao, Hu, Sem H, Phan
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Scientific Reports, 2021 Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described.
Giuseppina Abignano +5 more
doaj +1 more source
Comparison of Myofibroblasts Between Solid/Multicystic Ameloblastoma and Unicystic Ameloblastoma: An Immunohistochemical Analysis [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Microenvironment is crucial for the maintenance of cellular functions and tissue integrity suggesting that cancer-induced changes in the stroma may contribute to cancer invasion and its biological behaviour. One of the major constituent
Gowdara Prakash Smitha +3 more
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Evaluation of Myofibroblasts by Expression of Alpha Smooth Muscle Actin: A Marker in Fibrosis, Dysplasia and Carcinoma [PDF]
Journal of Clinical and Diagnostic Research, 2014 Objective: Evaluation of Myofibroblasts by studying expression of Alpha smooth muscle actin: A marker of Fibrosis, Dysplasia and Carcinoma. Background: Myofibroblasts are cells that have contractile properties and are involved in inflammation, wound ...
Bharath Rao K +3 more
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The American Journal of Pathology, 2007 The crucial role played by the myofibroblast in wound healing and pathological organ remodeling is well established; the general mechanisms of extracellular matrix synthesis and of tension production by this cell have been amply clarified. This review discusses the pattern of myofibroblast accumulation and fibrosis evolution during lung and liver ...
HINZ B +5 more
openaire +5 more sources
Time-dependent appearance of myofibroblasts in granulation tissue of human skin wounds [PDF]
, 1992 Human skin wounds (66) inflicted between 20 h and 7 months prior to biopsy were studied. In order to identify the type of cellular differentiation of the fibroblastic cells in the granulation tissue, alpha-smooth muscle actin and desmin were ...
Penning, R. +5 more
core +1 more source
ESSENTIAL ROLE OF LYN IN FIBROSIS
Frontiers in Physiology, 2016 Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Hung Pham +10 more
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Stromal Myofibroblasts Are Associated with Poor Prognosis in Solid Cancers: A Meta-Analysis of Published Studies. [PDF]
PLoS ONE, 2016 Published studies have evaluated the impact of stromal myofibroblasts on prognosis in solid cancers. However, the results of these studies remain controversial.
Liu Liu +5 more
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Editorial: Liver Myofibroblasts [PDF]
Frontiers in Physiology, 2016 Myofibroblasts (MFB) were first identified in the granulation tissue of healing wounds. They have features of both fibroblasts and smooth muscle cells. In contrast to fibroblasts they contain cytoplasmic actin microfilaments (stress fibers) connected to the extracellular matrix (ECM) by focal contacts.
Kanta, Jiri +2 more
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Human liver myofibroblasts during development and diseases with a focus on portal (myo)fibroblasts.
Frontiers in Physiology, 2015 Myofibroblasts are stromal cells mainly involved in tissue repair. These cells present contractile properties and play a major role in extracellular matrix deposition and remodeling. In liver, myofibroblasts are found in two critical situations.
Sébastien eLepreux +1 more
doaj +1 more source