Results 141 to 150 of about 89,329 (241)

α-SMA as a Mesenchymal marker in Chronic Hepatitis C Infection.

Pakistan Journal of Medicine and Dentistry
Background: Liver biopsy so far, is the mainstay of diagnosing hepatic fibrosis. Activated HSCs express certain mesenchymal markers, of which Smooth Muscle Actin is a well-known marker.
Sobia Hassan, Sofia Amjad, Farah Ahmed
doaj  

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

采用双重免疫组织化学及免疫电镜方法可将α-平滑肌肌动蛋白定位于乳腺癌间质新生血管周细胞

Zhongguo shiyan zhenduanxue, 2002
目的　观察周细胞形态特点 ,并寻找其标记物。方法　应用双重免疫组织化学及免疫电镜方法 ,观察α -平滑肌肌动蛋白 （α -SMA）在周细胞内的表达情况。结果　免疫组织化学染色发现α -SMA在周细胞内表达 ,而在内皮细胞内不表达 ;免疫电镜可见α-SMA仅定位于周细胞。结论　免疫组织化学方法和免疫电镜方法是一种有效的实验手段 ,采用此种方法提出α ...
王医术, 李玉林, 王心蕊, 李一雷, 张丽红, 吴珊   +5 more
doaj  

Correlation between α-SMA and ß-catenin levels in bronchoalveolar lavage fluid and severity of pneumonia. [PDF]

Pak J Med Sci, 2022
Li X, Jiang Z.
europepmc   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Activation of the TGF-β1/Smads/α-SMA pathway is related to histological and functional changes in children with neurogenic bladder. [PDF]

Sci Rep, 2022
Yang X, Pu Q, Wen Y, Zhao Y, Wang J, Xu P, Ma Y, Liu E, Lv L, Wen JG.   +9 more
europepmc   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Immunohistochemical expression of p53, Ki67, α-SMA, CD44 and CD31 in different histological subtypes of basal cell carcinoma. [PDF]

Rom J Morphol Embryol, 2022
Cojocaru A, Bîrjovanu C, Ciurea AM, Niculescu D, Orzan OA, Ion A, Alexandru DO, Pirici I, Vîlcea EJ, Marinescu EA, Ciurea ME.   +10 more
europepmc   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

BAG3 induces α-SMA expression in human fibroblasts and its over-expression correlates with poorer survival in fibrotic cancer patients. [PDF]

J Cell Biochem, 2022
De Marco M, Del Papa N, Reppucci F, Iorio V, Basile A, Falco A, Iaccarino R, Brongo S, De Caro F, Capunzo M, Turco MC, Rosati A, Marzullo L.   +12 more
europepmc   +1 more source