Advanced Science, EarlyView.PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia +14 more
wiley +1 more source
Case Report: Progression of a Silent Corticotroph Tumor to an Aggressive Secreting Corticotroph Tumor, Treated by Temozolomide. Changes in the Clinic, the Pathology, and the β-Catenin and α-SMA Expression. [PDF]
Front Endocrinol (Lausanne), 2022 Demarchi G +7 more
europepmc +1 more source
Advanced Science, EarlyView.Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan +19 more
wiley +1 more source
Correction to: TGF‑β‑induced α‑SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells. [PDF]
Mol Med, 2021 Ding H, Chen J, Qin J, Chen R, Yi Z.
europepmc +1 more source
Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration
Advanced Science, EarlyView.A bioabsorbable endovascular adhesive tape (BEAT) platform based on a hierarchical polyelectrolyte complex is developed to enhance drug delivery in the DCB system. The coating enables rapid transfer to the vessel, provides short‐term mechanical support, and promotes both immediate transfer and long‐term retention of drugs at the lesion site.
Jiarong Wang +13 more
wiley +1 more source
Reduced receptor for advanced glycation end products is associated with α-SMA expression in patients with idiopathic pulmonary fibrosis and mice. [PDF]
Lab Anim Res, 2021 Baek H +8 more
europepmc +1 more source
Advanced Science, EarlyView.Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel +11 more
wiley +1 more source
PCI-neo-肝细胞生长因子对脂多糖刺激的大鼠肾小球系膜细胞α-平滑肌肌动蛋白表达的影响
Zhongguo shiyan zhenduanxue, 2016 目的探讨PCI-neo-肝细胞生长因子（PCI-neo-HGF）对脂多糖（LPS）刺激的大鼠肾小球系膜细胞（GMCs）的α-平滑肌肌动蛋白（α-SMA）的表达是否有抑制作用,以及这种抑制作用是否与对转化生长因子-β1（TGF-β1）表达的抑制有关。方法体外培养GMCs并分为5组,（1）Ctrl:对照;（2）C+L:GMCs+LPS（10μg/ml）;（3）C+L+P-n:GMCs+LPS（10μg/ml）+PCI-neo（2μg）;（4）C+L+P-n-H2:GMCs+LPS（10μg/ml）+PCI ...
王红月, 张洋, 刘丽, 顾春梅
doaj
Umbilical Cord-Derived Mesenchymal Stem Cells Improve TGF-β, α-SMA and Collagen on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats. [PDF]
Med Arch, 2022 Mukti AI +7 more
europepmc +1 more source
Advanced Science, EarlyView.A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang +8 more
wiley +1 more source