Advanced Science, EarlyView.In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li +15 more
wiley +1 more source
Case Report: Progression of a Silent Corticotroph Tumor to an Aggressive Secreting Corticotroph Tumor, Treated by Temozolomide. Changes in the Clinic, the Pathology, and the β-Catenin and α-SMA Expression. [PDF]
Front Endocrinol (Lausanne), 2022 Demarchi G +7 more
europepmc +1 more source
Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics
Advanced Science, EarlyView.The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet +8 more
wiley +1 more source
Correction to: TGF‑β‑induced α‑SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells. [PDF]
Mol Med, 2021 Ding H, Chen J, Qin J, Chen R, Yi Z.
europepmc +1 more source
A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes
Advanced Science, EarlyView.We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen +13 more
wiley +1 more source
PCI-neo-肝细胞生长因子对脂多糖刺激的大鼠肾小球系膜细胞α-平滑肌肌动蛋白表达的影响
Zhongguo shiyan zhenduanxue, 2016 目的探讨PCI-neo-肝细胞生长因子（PCI-neo-HGF）对脂多糖（LPS）刺激的大鼠肾小球系膜细胞（GMCs）的α-平滑肌肌动蛋白（α-SMA）的表达是否有抑制作用,以及这种抑制作用是否与对转化生长因子-β1（TGF-β1）表达的抑制有关。方法体外培养GMCs并分为5组,（1）Ctrl:对照;（2）C+L:GMCs+LPS（10μg/ml）;（3）C+L+P-n:GMCs+LPS（10μg/ml）+PCI-neo（2μg）;（4）C+L+P-n-H2:GMCs+LPS（10μg/ml）+PCI ...
王红月, 张洋, 刘丽, 顾春梅
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Reduced receptor for advanced glycation end products is associated with α-SMA expression in patients with idiopathic pulmonary fibrosis and mice. [PDF]
Lab Anim Res, 2021 Baek H +8 more
europepmc +1 more source
Advanced Science, EarlyView.The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang +9 more
wiley +1 more source
Umbilical Cord-Derived Mesenchymal Stem Cells Improve TGF-β, α-SMA and Collagen on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats. [PDF]
Med Arch, 2022 Mukti AI +7 more
europepmc +1 more source
Advanced Science, EarlyView.This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan +10 more
wiley +1 more source