Results 221 to 230 of about 89,329 (241)

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis

Advanced Science, EarlyView.
SeZM NPs selectively target M2b macrophages through mannose–MRC1 (CD206) recognition, enhance GPX1 biosynthesis, and suppress mitochondrial ROS generation, oxidative stress, and JAK–STAT signaling. This dual regulation reduces pro‐inflammatory cytokine release, limits immune cell infiltration and fibrosis, and preserves renal function, providing a ...
Haoran Lv, Guanning Huang, Hongyu Li, Hanzhi Liang, Huajing Peng, Kefei Wu, Wenfang Chen, Dandan Zhang, Kexin Ma, Yufei Du, Siweier Luo, Yi Zhou, Haiping Mao, Wei Chen, Tianfeng Chen, Yiming Zhou, Qinghua Liu   +16 more
wiley   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, EarlyView.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

Advanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang, Zi‐Han Chen, Jiajia Li, Wei Hu, Ying Cao, Yu Wang, Xiaoyu Tong, Wenhan Lu, Yuze Yang, Yuehao Wang, Yan Xiao, Wenhao Gao, Yuning Chen, Yuyan Hou, Fan Zhang, Yi Feng   +15 more
wiley   +1 more source

Overexpression of B7-H3 in α-SMA-Positive Fibroblasts Is Associated With Cancer Progression and Survival in Gastric Adenocarcinomas. [PDF]

Front Oncol, 2019
Zhan S, Liu Z, Zhang M, Guo T, Quan Q, Huang L, Guo L, Cao L, Zhang X.   +8 more
europepmc   +1 more source

On the Ordering Mechanism of Cu+ in 2D van der Waals Multiferroic CuCrP2S6

Advanced Science, EarlyView.
Temperature‐dependent X‐ray single‐crystal diffuse scattering measurements of CuCrP2S6 in the (H, K, 0) plane reveal the gradual emergence and strengthening of short‐range order upon cooling from 230 to 170 K. At intermediate temperatures, diffuse features become pronounced and eventually lock into sharp incommensurate satellite reflections, indicating
Jiasen Guo, Yongqiang Cheng, Michael A. Susner, Ryan P. Siebenaller, Zachary Morgan, Feng Ye   +5 more
wiley   +1 more source

Exchange Length Tailored Magnetic Resonance for Broadband Absorption in FeCo‐Based Alloys

Advanced Science, EarlyView.
To break the high‐frequency magnetic loss bottleneck in soft magnetic alloys, a magnetic exchange length (Lex)‐guided strategy is proposed. Cu doping increases Lex and intergranular coupling, which effectively reduces magnetic anisotropy and pushes the exchange resonance to 12.0 GHz.
Xiaoyang Liu, Yingli Zhu, Shuangxin Zhang, Gangtao Luo, Mengke Qiao, Jiang Wu, Xiangcheng Li   +6 more
wiley   +1 more source

Liquid Metal Elastomer Based Coplanar Waveguide Transmission Line for Stretchable and Self‐Healing RF Electronics

Advanced Electronic Materials, EarlyView.
This work shows the first proof‐of‐concept for fully self‐healing and stretchable coplanar waveguide (CPW) transmission line using printable electrically conductive liquid metal elastomer. RF performance was evaluated in frequency ranging from 1 to 6 GHz under uniaxial tensile strain up to 100%, after self‐healing, and for 1000 cyclic stretch‐release ...
Ahmed Albeltagi, Tiia Tyystälä, Mikko Nelo, Heli Jantunen, Jari Juuti, Jarkko Tolvanen, Jari Hannu   +6 more
wiley   +1 more source

Device Performance of Emerging Photovoltaic Materials (Version 6)

Advanced Energy Materials, EarlyView.
Efficiency of single junction perovskite (circles), organic (hexagons), dye sensitized (pentagons), kesterite (diamonds), Sb2Se3 (right triangle), and AgBiS2 (left triangles) solar cells at emerging‐pv.org over the last decade. ABSTRACT This 6th annual Emerging PV Report surveys peer‐reviewed advances since August 2024 across perovskite, organic ...
Osbel Almora, Agustin O. Alvarez, Derya Baran, Carlos I. Cabrera, Luigi A. Castriotta, Bruno Ehrler, Sule Erten‐Ela, Kenjiro Fukuda, Fei Guo, Jens Hauch, Anita W.Y. Ho‐Baillie, T. Jesper Jacobsson, Rene A. J. Janssen, Thomas Kirchartz, Maria A. Loi, Richard R. Lunt, Xavier Mathew, Jie Min, David B. Mitzi, Mohammad K. Nazeeruddin, Ana F. Nogueira, Ulrich W. Paetzold, Nam‐Gyu Park, Barry P. Rand, Henry Snaith, Takao Someya, Christian Sprau, Lulu Sun, Karen Forberich, Christoph J. Brabec   +29 more
wiley   +1 more source