Results 221 to 230 of about 90,445 (239)

Aligned Fibronectin Microenvironment Temporally Facilitates Profibrotic Fibroblast Activation via Integrin α5β1

Advanced Science, EarlyView.
Compared to a healthy random nanofibrous fibronectin microenvironment, a fibrotic aligned nanofibrous fibronectin microenvironment employs a specific integrin, α5β1 integrin, to activate early pro‐fibrotic fibroblast behaviors and later fibrotic fibroblast tissue formation with cell/F‐actin alignment, α‐SMA expression, and cell‐driven aligned ...
Doğuhan Beyatlı, Mika Brown, George‐Radu Romanescu, Seungkuk Ahn   +3 more
wiley   +1 more source

Exchange Length Tailored Magnetic Resonance for Broadband Absorption in FeCo‐Based Alloys

Advanced Science, EarlyView.
To break the high‐frequency magnetic loss bottleneck in soft magnetic alloys, a magnetic exchange length (Lex)‐guided strategy is proposed. Cu doping increases Lex and intergranular coupling, which effectively reduces magnetic anisotropy and pushes the exchange resonance to 12.0 GHz.
Xiaoyang Liu, Yingli Zhu, Shuangxin Zhang, Gangtao Luo, Mengke Qiao, Jiang Wu, Xiangcheng Li   +6 more
wiley   +1 more source

Sub‐Micrometer‐Precision Path Following of Piezo‐Actuated Mobile Robot

Advanced Intelligent Systems, EarlyView.
This article reports on the Holonomic‐Beetle (HB), a palm‐sized robot that achieves sub‐micrometer (sub‐µm) precision path tracking across spatial ranges from 100 µm to 10 mm. Using proportional‐integral‐derivative (PID) control, the HB accurately tracks both complex and straight paths with sub‐µm path errors, surpassing existing robots.
Eiji Kusui, Chihiro Sekine, Taiki Goto, Ryosuke Kinoshita, Yuko Nishimura, Shogen Sekiguchi, Satoshi Ando, Yuto Oishi, Yusuke Matsui, Ohmi Fuchiwaki   +9 more
wiley   +1 more source

A Neural Network‐Based Self‐Sensing Embedded Position Control System for Shape Memory Alloy Wire Actuators

Advanced Intelligent Systems, EarlyView.
Shape memory alloy wires exhibit thermally induced phase changes that generate actuation strain and resistance variations enabling self‐sensing. However, hysteretic electromechanical behavior complicates accurate state estimation. This paper presents an artificial in‐based self‐sensing method to reconstruct SMA actuator position in real time, achieving
Krunal Koshiya, Gianluca Rizzello, Paul Motzki   +2 more
wiley   +1 more source

Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors

Angewandte Chemie, EarlyView.
Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann, Constanze C. Schmies, Georg Wilhelm Rolshoven, Mirko Scortichini, Stefan Wagner, Andreas Isaak, Riham M. Idris, Jennifer Dabel, Lucie Grey, Karolina Losenkova, Susanne Moschütz, Haneen Al Hroub, Antje Keim, Sandra Höppner, Jouko Sandholm, Pia Boström, Maija Hollmén, Norbert Sträter, Sven Hermann, Gennady G. Yegutkin, Kenneth A. Jacobson, Sonja Schelhaas, Christa E. Müller, Anna Junker   +23 more
wiley   +2 more sources

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva, Karen Herbert, Lakshmi Balaji, Jia Mei He, Tejaswi Kandula, Hugo A. Sampaio, Hooi‐Ling Teoh, Esther Tantsis, Jihee Sohn, Nancy Briggs, Nickson Ning, Matthew C. Kiernan, Didu S. Kariyawasam, Michelle A. Farrar   +13 more
wiley   +1 more source

Overexpression of B7-H3 in α-SMA-Positive Fibroblasts Is Associated With Cancer Progression and Survival in Gastric Adenocarcinomas. [PDF]

Front Oncol, 2019
Zhan S, Liu Z, Zhang M, Guo T, Quan Q, Huang L, Guo L, Cao L, Zhang X.   +8 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Long Non‐Coding RNA H19 mediates STAT3 dependent activation of keratinocytes and fibroblasts in Systemic Sclerosis skin

Arthritis &Rheumatology, Accepted Article.
Objective Dermal Systemic Sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with lncRNA H19 (H19) highlighted as the most upregulated RNA in their cargo compared to healthy control (HC). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz, Christopher W Wasson, Rebecca L Ross, Francesco Del Galdo   +3 more
wiley   +1 more source