Results 21 to 30 of about 89,329 (241)

SELECTIVE MEASUREMENT OF α SMOOTH MUSCLE ACTIN: WHY β-ACTIN CAN NOT BE USED AS A HOUSEKEEPING GENE WHEN TISSUE FIBROSIS OCCURS [PDF]

, 2017
Background Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide.
Andrea Fekete, Apor Veres-Székely, Attila J. Szabó, B Hinz, BJ Perrin, CW Dieffenbach, Domonkos Pap, EM Zeisberg, Erna Sziksz, Eszter Jávorszky, J Axtner, J Lin, KJ Livak, Kálmán Tory, L Hecker, M Heim, M Zeybel, MA Valasek, MM Mukaka, NC Henderson, Q Zhang, Rita Lippai, Réka Rokonay, S Hao, S Lemoinne, SA Bustin, T Nolan, TA Wynn, TA Wynn, Tivadar Tulassay, TR Cox, VS LeBleu, VS LeBleu, W Bechtel, Y Liu, Ádám Vannay   +35 more
core   +3 more sources

Myofibroblasts are increased in the lung parenchyma in asthma.

PLoS ONE, 2017
BackgroundIncreased airway smooth muscle is observed in large and small airways in asthma. Semi-quantitative estimates suggest that cells containing alpha smooth muscle actin (α-SMA) are also increased in the lung parenchyma.
Stacey R Boser, Thais Mauad, Bianca Bergamo de Araújo-Paulino, Ian Mitchell, Grishma Shrestha, Andrea Chiu, John Butt, Margaret M Kelly, Elia Caldini, Alan James, Francis H Y Green   +10 more
doaj   +1 more source

Expression of visual system homeobox 1 in human keratoconus [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the expression of visual system homeobox 1 (VSX1) and myofibroblast marker alpha smooth muscle actin (α-SMA) in keratoconus (KC). METHODS: Thirty corneal tissue were collected from KC patients after corneal transplantation and 15 ...
Ya-Ni Wang, Xian-Ning Liu, Xiao-Dong Wang, Yong Yin, Yan Chen, Xiang-Hua Xiao, Kun Xu, Xiu-Ping Zhu   +7 more
doaj   +1 more source

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro. [PDF]

, 2011
OBJECTIVE: The origin of the mesenchymal cells responsible for the intimal fibrosis in systemic sclerosis (SSc) has not been fully identified. The present study was undertaken to investigate whether subendothelial mesenchymal cells may emerge through ...
Jimenez, Sergio A., Li, zhaodong
core   +2 more sources

Intratumoral α-SMA enhances the prognostic potency of CD34 associated with maintenance of microvessel integrity in hepatocellular carcinoma and pancreatic cancer. [PDF]

PLoS ONE, 2013
Microvessel density (MVD) as an angiogenesis predictor is inefficient per se in cancer prognosis. We evaluated prognostic values of combining intratumoral alpha-smooth muscle actin (α-SMA)-positive stromal cell density and MVD after curative resection in
Wen-Quan Wang, Liang Liu, Hua-Xiang Xu, Guo-Pei Luo, Tao Chen, Chun-Tao Wu, Yong-Feng Xu, Jin Xu, Chen Liu, Bo Zhang, Jiang Long, Zhao-You Tang, Xian-Jun Yu   +12 more
doaj   +1 more source

c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells [PDF]

, 2014
BACKGROUND: Hard consistency, developed under the influence of tumor cell factors, is a characteristic feature of a breast tumor. Activation of resident fibroblasts leading to a myofibroblast phenotype is the principal feature that orchestrates this ...
Carla Urra, Jorge Martínez, Marcela Toyos, Nicolás Méndez, Nicolás Tobar, Patricio C Smith, Rodrigo Arancibia   +6 more
core   +1 more source

Histone demethylase retinoblastoma binding protein 2 regulates the expression of -smooth muscle actin and vimentin in cirrhotic livers

Brazilian Journal of Medical and Biological Research, 2013
Liver cirrhosis is one of the most common diseases of Chinese patients. Herein, we report the high expression of a newly identified histone 3 lysine 4 demethylase, retinoblastoma binding protein 2 (RBP2), and its role in liver cirrhosis in humans.
Q. Wang, L.X. Wang, J.P. Zeng, X.J. Liu, X.M. Liang, Y.B. Zhou   +5 more
doaj   +1 more source

Expression pattern analysis and drug differential sensitivity of cancer-associated fibroblasts in triple-negative breast cancer

Translational Oncology, 2021
Triple-negative breast cancer (TNBC) has the characteristics of a complex molecular landscape, aggressive or high proliferation leading to poor prognosis, and behavioral heterogeneity.
Qilong Li, Mohan Li, Kexin Zheng, Shuang Tang, Shiliang Ma   +4 more
doaj   +1 more source

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]

, 2018
Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O., Carubbi F., Ciccia F., Cipriani P., Di Bartolomeo S., Di Benedetto P., Giacomelli R., Guggino G., Liakouli V., Panzera N., Ruscitti P., Triolo G.   +11 more
core   +1 more source

Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis [PDF]

, 2015
Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth factor β1-mediated epithelial to ...
AA Eddy, Arif Khwaja, B Conway, B Hinz, C Stambe, D Bokemeyer, D Bokemeyer, D Feliers, David Long, DY Rhyu, E Diaz-Flores, Faith Hannah Nutter, FY Ma, FY Ma, FY Ma, G Wolf, GA Reif, GM D'Abaco, H Fujita, H Ha, H Tamouza, HJ Anders, J Chen, John L. Haylor, JW Pippin, JY Seo, L Aoudjit, LF Allen, LL Huang, M Peake, M Sabbatini, M Zeisberg, MA Chetram, MH De Borst, N Sakai, P Moreno-Layseca, PM Lorusso, R Ohashi, R Roskoski Jr, S Omori, S Wang, S Wang, SD Oldroyd, SK Jo, SP Davies, T Ishida, T Masaki, T Wada, T Xu, W Bechtel, Y Han   +50 more
core   +6 more sources