Results 31 to 40 of about 89,329 (241)

The Importance of Stroma and Stromal SMA Expression in Pancreatic Ductal Adenocarcinoma [PDF]

Türk Patoloji Dergisi
Objective: Pancreatic stellate cells (PSC) have been defined to be the key players in pancreatic fibrogenesis and carcinogenesis. They undergo myofibroblast-like differentiation, express α-smooth muscle actin (α-SMA), and play a crucial role in injury ...
Gamze AKBAS, Pelin BAGCI
doaj   +1 more source

Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury

Renal Failure, 2020
Remote renal injury is a drastic consequence of hepatic ischemia/reperfusion (IR) injury. Vildagliptin (V) is a dipeptidyl peptidase-4 inhibitor that has a hepatorenal protective effect against models of liver and renal IR.
Iman O. Sherif, Alaa A. Alshaalan, Nora H. Al-Shaalan   +2 more
doaj   +1 more source

Essential Role of Lyn in Fibrosis. [PDF]

, 2016
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Birtolo, Chiara, Chheda, Chintan, Cirulli, Vincenzo, Gugliotta, Gabriele, Lewis, Michael S, Liu, Sandy T, Pandol, Stephen J, Pham, Hung, Ptasznik, Andrzej, Rodriguez, Maria D, Yang, Wendy   +10 more
core   +2 more sources

Extracellular HSP70/HSP70-PCs promote epithelial-mesenchymal transition of hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
BackgroundExtracellular heat shock protein 70 and peptide complexes (eHSP70/HSP70-PCs) regulate a variety of biological behaviors in tumor cells. Whether eHSP70/HSP70-PCs are involved in the epithelial-mesenchymal transition (EMT) of tumor cells remains ...
Hangyu Li, Yan Li, Dan Liu, Hongzhi Sun, Dongming Su, Fuquan Yang, Jingang Liu   +6 more
doaj   +1 more source

Impact of cancer-associated fibroblasts on survival of patients with ampullary carcinoma

Frontiers in Oncology, 2023
BackgroundCancer-associated fibroblasts (CAFs) reportedly enhance the progression of gastrointestinal surgery; however, the role of CAFs in ampullary carcinomas remains poorly examined.
Kosei Takagi, Kazuhiro Noma, Yasuo Nagai, Satoru Kikuchi, Yuzo Umeda, Ryuichi Yoshida, Tomokazu Fuji, Kazuya Yasui, Takehiro Tanaka, Hajime Kashima, Takahito Yagi, Toshiyoshi Fujiwara   +11 more
doaj   +1 more source

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 [PDF]

, 2018
Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is ...
A Clayton, A Desmouliere, A Holmes, A Yabuki, AA Eddy, AA Eddy, AC Sanchez-Lara, BL Aken, C Grupp, C. P. D. Wheeler-Jones, CH Heldin, CL Marino, E Honda, E Van Obberghen-Schilling, F Strutz, F Strutz, F Syeda, GR Grotendorst, H. M. Syme, HP Rodemann, J Ivaska, J Lu, J. Elliott, J. S. Lawson, JL Mumaw, JS Lawson, K Sawashima, KG McCullagh, KJ Kelynack, LC Penning, M Prunotto, M Zeisberg, MA Venkatachalam, MJ Ryan, MK Phanish, ML Sequeira Lopez, P Boor, P Sysa, PC Bartlett, Q Chai, RA Ignotz, S Chakrabarti, S Meran, S Moll, S Neelisetty, SC Chen, SL Lin, SP DiBartola, SW Smith, T Akamatsu, TA Wynn, V Dugina, VS Lebleu, W Bloom, WA Border, X Pan, XM Meng, Y Hosokawa, Y Liu   +58 more
core   +2 more sources

Schisandrin B regulates the SIRT1/PI3K/Akt signaling pathway to ameliorate Ang II-infused cardiac fibrosis [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Schisandrin B (SchB), extracted from Schisandra chinensis, has antimicrobial and anti-inflammatory effects. The study aimed to investigate SchB’s possible defense against angiotensin II (Ang II)-infused cardiac fibrosis and its molecular ...
Xiaogang Zhang, Mengqing Shi, Zhongying Xing, Jie Su, Yuying Gu, Zhongping Ning   +5 more
doaj   +1 more source

RNA interference against platelet-derived growth factor receptor α mRNA inhibits fibroblast transdifferentiation in skin lesions of patients with systemic sclerosis. [PDF]

PLoS ONE, 2013
OBJECTIVE: To down-regulate expression of mRNA for the platelet-derived growth factor receptor (PDGFR)-α, block the signalling pathway of PDGF and its receptor, and study their influence on fibroblast transdifferentiation to myofibroblasts in systemic ...
Tong Liu, Jian Zhang, Jing Zhang, Xin Mu, Hui Su, Xiaoding Hu, Wenli Liu, Enbing Zhao, Weimin Li   +8 more
doaj   +1 more source

Fibrotic and Vascular Remodelling of Colonic Wall in Patients with Active Ulcerative Colitis [PDF]

, 2016
open16noIntestinal fibrosis is a complication of inflammatory bowel disease [IBD]. Although fibrostenosis is a rare event in ulcerative colitis [UC], there is evidence that a fibrotic rearrangement of the colon occurs in the later stages.
Bassotti, Gabrio, Bernardini, Nunzia, Blandizzi, Corrado, Buccianti, Piero, Campani, Daniela, Castagna, Maura, Colucci, Rocchina, Di Candio, Giulio, Dolfi, Amelio, ERREDE, Mariella, GIROLAMO, FRANCESCO, Ippolito, Chiara, Segnani, Cristina, Tirotta, Erika, Villanacci, Vincenzo, VIRGINTINO, Daniela   +15 more
core   +2 more sources

Expression Levels of α-SMA and Vimentin in Spindle Cells and Their Relationship with Prognosis of Patients with Myxofibrosarcoma

Zhongliu Fangzhi Yanjiu
ObjectiveTo analyze the expression levels of a-smooth muscle actin (α-SMA) and Vimentin in spindle cells and their relationship with the prognosis of patients with myxofibrosarcoma (MFS). MethodsThe imaging, clinical, and pathological data of 61 patients
Guohui WU, Yan ZHANG
doaj   +1 more source