Results 41 to 50 of about 89,329 (241)

Silicone rubber hardness regulates fibroblasts proliferation and expression of α-SMA and CollagenⅠ by autophagy

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of different hardness of silicone rubber (SRs) on the proliferation and expression of α- SMA and Collagen Ⅰ in human dermal fibroblasts (HFBs), and study the role of autophagy in the process.
WANG Hailin, GAO Yang, SHI Xiaohua, DU Yichen, ZHANG Yiming, FAN Dongli   +5 more
doaj   +1 more source

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation [PDF]

, 2016
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful.
Bellomo, C, Bickle, M, Carthy, JM, Gahman, TC, Heldin, A, Heldin, CH, Kardassis, D, Morén, A, Moustakas, A, Shiau, AK, Stöter, M, Vanlandewijck, M, Zerial, M   +12 more
core   +1 more source

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts

Cells, 2020
We identify the focal adhesion protein kindlin-2 as player in a novel mechanotransduction pathway that controls profibrotic cardiac fibroblast to myofibroblast activation. Kindlin-2 is co-upregulated with the myofibroblast marker α-smooth muscle actin (α-
Elena Godbout, Dong Ok Son, Stephanie Hume, Stellar Boo, Vincent Sarrazy, Sophie Clément, Andras Kapus, Bernhard Wehrle-Haller, Leena Bruckner-Tuderman, Cristina Has, Boris Hinz   +10 more
doaj   +1 more source

Ki67, CD105, and α-SMA expression supports the transformation relevant dysplastic features in the atrophic epithelium of oral submucous fibrosis. [PDF]

PLoS ONE, 2018
BACKGROUND:The grading of oral epithelial dysplasia is not possible in the atrophic epithelium of oral submucous fibrosis (OSMF). Recently, we found that features such as increased basal cell layer hyperplasia, abnormal superficial mitosis, increased ...
Amol R Gadbail, Minal Chaudhary, Sachin C Sarode, Shailesh Gondivkar, Satyajit A Tekade, Prajakta Zade, Alka Hande, Gargi S Sarode, Shankargouda Patil   +8 more
doaj   +1 more source

Growth factor restriction impedes progression of wound healing following cataract surgery: identification of VEGF as a putative therapeutic target [PDF]

, 2016
Secondary visual loss occurs in millions of patients due to a wound-healing response, known as posterior capsule opacification (PCO), following cataract surgery. An intraocular lens (IOL) is implanted into residual lens tissue, known as the capsular bag,
A Parenti, AJ Maloof, B Amoozgar, B Hinz, B Lundqvist, B Thylefors, BP Danysh, C Biagi, D Belotti, D Spalton, D Xu, G Duncan, G Duncan, GC Brown, IM Wormstone, IM Wormstone, IM Wormstone, IM Wormstone, IM Wormstone, J Nagata, JA Eldred, JA Eldred, JF Boyce, JL Davis, JL Kovach, K Hayashi, K Ohta, L Leishman, MA Nanavaty, N Ferrara, NI Chaudhary, NV Palejwala, O Nishi, PJ Sime, R Alon, RJ Kelly, RL Avery, RU de Iongh, S Resnikoff, SC Kavoussi, T Hara, T Hara, TM Rabsilber, W Wu, X Huang   +44 more
core   +1 more source

Differentiation potential of CD14+ monocytes into myofibroblasts in patients with systemic sclerosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Circulating monocytes are a highly plastic and functionally heterogeneic cell type with an activated phenotype in patients with systemic sclerosis (SSc).
Nadine Binai, Steven O'Reilly, Bridget Griffiths, Jacob M van Laar, Thomas Hügle   +4 more
doaj   +1 more source

Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy? [PDF]

, 2015
Dupuytren's contracture (DC) is a benign fibro-proliferative disease of the hand causing fibrotic nodules and fascial cords which determine debilitating contracture and deformities of fingers and hands.
Alberto Signore, Caterina Chiappetta, Cira Di Gioia, Elena Pompili, Enrica Bianchi, Francesco S. Pastore, Lia Bardella, Lorenzo Fumagalli, Marco Artico, Samanta Taurone, Susanna Scarpa, Vincenzo Sessa   +11 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Expression of α-smooth muscle actin in the periodontal ligament during post-emergent tooth eruption

Journal of International Medical Research, 2018
Objective This study was performed to explore the expression of α-smooth muscle actin (α-SMA) in the periodontal ligament (PDL) of young and adult rats during post-emergent tooth eruption in opposed and unopposed teeth at two time points: 3 and 15 days ...
Domna Dorotheou, Marie-Luce Bochaton-Piallat, Catherine Giannopoulou, Stavros Kiliaridis   +3 more
doaj   +1 more source

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease. [PDF]

, 2016
OBJECTIVE: To examine whether lung endothelial cells (ECs) from patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) express mesenchymal cell-specific proteins and gene transcripts, indicative of the occurrence of endothelial-
Arciniegas, Beon, Cooley, Del Galdo, Falke, Gabrielli, Gilbane, Good, Goumans, Hashimoto, Herzog, Herzog, Hinz, Hinz, Humphreys, Jimenez, Katsumoto, Kendall, Kramann, Lamouille, LeBleu, Li, Li, Marelli-Berg, Matucci-Cerinic, McAnulty, Medici, Meeteren, Nolan, Pattanaik, Piera-Velazquez, Piera-Velazquez, Poslethwaite, Ranchoux, Rieder, Strieter, Varga, Veraldi, Wells, Yoshimatsu, Zeisberg, Zeisberg   +41 more
core   +2 more sources