Results 1 to 10 of about 6,467 (115)

Good Manufacturing Practice Validation and Radiation Dosimetry for the Clinical Application of a Novel α7-nAChR Radioligand: [¹¹C]KIn83. [PDF]

Molecules
Nicotinic acetylcholine receptor (α7-nAChR) plays a crucial role in cognitive functions like memory and attention. Positron emission tomography (PET) imaging of α7-nAChR is gaining attraction for understanding and monitoring central nervous system disorders, such as Alzheimer’s disease, Parkinson’s disease, and schizophrenia. We developed [11C]KIn83, a
Jia Z, Bolin M, Morén AF, Datta P, Asem H, Ågren H, Långström B, Nordberg A, Halldin C, Nag S.   +9 more
europepmc   +5 more sources

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site. [PDF]

Toxins (Basel), 2021
α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR.
Gulsevin A, Papke RL, Stokes C, Tran HNT, Jin AH, Vetter I, Meiler J.   +6 more
europepmc   +2 more sources

Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier. [PDF]

Front Immunol, 2021
Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) is critical for the pathogenesis of Escherichia coli (E. coli) K1 meningitis, a severe central nervous system infection of the neonates. However, little is known about how E.
He X, Wang L, Liu L, Gao J, Long B, Chi F, Hu T, Wan Y, Gong Z, Li L, Zhen P, Zhang T, Cao H, Huang SH.   +13 more
europepmc   +2 more sources

Sulfonium Ligands of the α7 nAChR. [PDF]

Molecules, 2021
Horenstein NA, Stokes C, Papke RL.
europepmc   +1 more source

The Effects of Positive Allosteric Modulators of α7-nAChR on Social Play Behavior in Adolescent Rats Prenatally Exposed to Valproic Acid. [PDF]

Pharmaceuticals (Basel), 2022
Gzielo K, Nikiforuk A.
europepmc   +1 more source

Correction to "Development of ¹¹C-Labeled ASEM Analogues for Detection of Neuronal Nicotinic Acetylcholine Receptors (α7-nAChR)". [PDF]

ACS Chem Neurosci, 2022
Nag S, Miranda-Azpiazu P, Jia Z, Datta P, Arakawa R, Moein M, Yang Z, Tu Y, Lemoine L, Ågren H, Nordberg A, Långström B, Halldin C.   +12 more
europepmc   +1 more source

An α7 nAChR approach for the baseline-dependent modulation of deviance detection in schizophrenia: A pilot study assessing the combined effect of CDP-choline and galantamine. [PDF]

J Psychopharmacol, 2023
Choueiry J, Blais CM, Shah D, Smith D, Fisher D, Labelle A, Knott V.   +6 more
europepmc   +1 more source

The Human-Restricted Isoform of the α7 nAChR, CHRFAM7A: A Double-Edged Sword in Neurological and Inflammatory Disorders. [PDF]

Int J Mol Sci, 2022
Di Lascio S, Fornasari D, Benfante R.
europepmc   +1 more source

Development of ¹¹C-Labeled ASEM Analogues for the Detection of Neuronal Nicotinic Acetylcholine Receptors (α7-nAChR). [PDF]

ACS Chem Neurosci, 2022
Nag S, Miranda-Azpiazu P, Jia Z, Datta P, Arakawa R, Moein MM, Yang Z, Tu Y, Lemoine L, Ågren H, Nordberg A, Långström B, Halldin C.   +12 more
europepmc   +1 more source

Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes. [PDF]

Acta Naturae, 2022
Bychkov ML, Kirichenko AV, Mikhaylova IN, Paramonov AS, Kirpichnikov MP, Shulepko MA, Lyukmanova EN.   +6 more
europepmc   +1 more source