Results 31 to 40 of about 6,788 (133)

Nicotine Elevated Intracellular Ca2+ in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating α7-Nicotinic Acetylcholine Receptor

Cellular Physiology and Biochemistry, 2014
Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with airway smooth muscle (ASM) hypertrophy and hyperplasia.
Yongliang Jiang, Aiguo Dai, Yumin Zhou, Gongyong Peng, Guoping Hu, Bing Li, James S.K. Sham, Pixin Ran   +7 more
doaj   +1 more source

Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. [PDF]

PLoS ONE, 2011
Alpha7 nicotinic acetylcholine receptor (nAChR), an essential regulator of inflammation, is abundantly expressed in hippocampal neurons, which are vulnerable to bacterial meningitis.
Feng Chi, Lin Wang, Xueye Zheng, Chun-Hua Wu, Ambrose Jong, Michael A Sheard, Wei Shi, Sheng-He Huang   +7 more
doaj   +1 more source

Targeting α7 nicotinic acetylcholine receptors for chronic pain

Frontiers in Molecular Neuroscience, 2022
Despite rapid advances in the field of chronic pain, it remains extremely challenging in the clinic. Pain treatment strategies have not improved for decades as opioids remain the main prescribed drugs for chronic pain management.
Ya-Qun Zhou, Dai-Qiang Liu, Cheng Liu, Ai-Jun Xu, Yu-Ke Tian, Wei Mei, Xue-Bi Tian   +6 more
doaj   +1 more source

The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper–zinc superoxide dismutase 1-mediated toxicity

Scientific Reports, 2020
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. Although many drugs have entered clinical trials, few have shown effectiveness in the treatment of ALS.
Taisei Ito, Masatoshi Inden, Tomoyuki Ueda, Yuta Asaka, Hisaka Kurita, Isao Hozumi   +5 more
doaj   +1 more source

Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression

Biomolecules, 2020
Immune response during sepsis is characterized by hyper-inflammation followed by immunosuppression. The crucial role of macrophages is well-known for both septic stages, since they are involved in immune homeostasis and inflammation, their dysfunction ...
Andrei E. Siniavin, Maria A. Streltsova, Denis S. Kudryavtsev, Irina V. Shelukhina, Yuri N. Utkin, Victor I. Tsetlin   +5 more
doaj   +1 more source

Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study

Molecules, 2021
Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a different structure and pharmacological profile modulate the rat α7 nAChR through
Yorley Duarte, Maximiliano Rojas, Jonathan Canan, Edwin G. Pérez, Fernando González-Nilo, Jesús García-Colunga   +5 more
doaj   +1 more source

Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. [PDF]

PLoS ONE, 2013
Presynaptic nicotinic acetylcholine receptors (nAChRs) have long been implicated in the modulation of CNS circuits. We previously reported that brief exposure to low concentrations of nicotine induced sustained potentiation of glutamatergic transmission ...
Chongbo Zhong, David A Talmage, Lorna W Role   +2 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases

Neurobiology of Disease, 2014
Microdeletion of the human CHRNA7 gene (α7 nicotinic acetylcholine receptor, nAChR) as well as dysfunction in N-methyl-d-aspartate receptors (NMDARs) have been associated with cortical dysfunction in a broad spectrum of neurodevelopmental and ...
Hong Lin, Fu-Chun Hsu, Bailey H. Baumann, Douglas A. Coulter, David R. Lynch   +4 more
doaj   +1 more source