Vagus nerve control of HMGB1 accessibility: a bioelectronic strategy for inflammation and pain [PDF]
Bioelectronic MedicineHigh mobility group box 1 protein (HMGB1) is a central mediator of inflammation and pain, but efforts to neutralize it therapeutically have had limited clinical success.
Huan Yang, Michael Brines, Ulf Andersson
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Psychopharmacology, 2021 There are controversial pieces of evidence whether combination therapies using memantine and cholinesterase inhibitors are beneficial over their monotreatments.
Nóra Bruszt +4 more
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Single particle tracking of alpha7 nicotinic AChR in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sites. [PDF]
PLoS ONE, 2010 Alpha7 neuronal nicotinic acetylcholine receptors (alpha7-nAChR) form Ca(2+)-permeable homopentameric channels modulating cortical network activity and cognitive processing.
Thomas Bürli +5 more
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Frontiers in Pharmacology, 2021 The α7 nicotinic acetylcholine receptor (α7nAChR) belongs to the superfamily of cys loop cationic ligand-gated channels, which consists of homogeneous α7 subunits.
Zhe‐Qi Xu +7 more
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[11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys. [PDF]
PLoS ONE, 2008 BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Kenji Hashimoto +8 more
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Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels [PDF]
Brain Research, 2009 Studies using the radio-labeled nicotinic receptor antagonist [(125)I]-alpha-bungarotoxin, which binds to alpha7 subunit containing nicotinic receptors, have demonstrated that mouse strains vary considerably in the number of alpha7-containing nicotinic receptors in brain.
Nathanial P, Brooks +2 more
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Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor. [PDF]
PLoS ONE, 2008 BACKGROUND: Cigarette smoking adversely affects endochondral ossification during the course of skeletal growth. Among a plethora of cigarette chemicals, nicotine is one of the primary candidate compounds responsible for the cause of smoking-induced ...
Atsuo Kawakita +6 more
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Cholinergic anti-inflammatory pathway and COVID-19 [PDF]
BioImpacts, 2022 The cholinergic anti-inflammatory pathway (CAP) first described by Wang et al, 2003 has contemporary interest arising from the COVID-19 pandemic. While tobacco smoking has been considered an aggravating factor in the severity of COVID-19 infections, it ...
Danial Mehranfard, Robert C. Speth
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Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides. [PDF]
PLoS ONE, 2009 BACKGROUND: The alpha-7 nicotinic acetylcholine receptor (alpha7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Cherie E Bond +2 more
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Frontiers in Ophthalmology, 2023 The role of acetylcholine (ACh) in visual processing in the mammalian retina has been the focus of research for many decades. Pioneering work on the localization of ACh discovered that the neurotransmitter is synthesized and stored in a distinct ...
David M. Linn
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