Results 41 to 50 of about 4,718 (156)

Alpha7 Nicotinic Acetylcholine Receptor Mediates Nicotine-induced Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma HepG2 Cells [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: The cytotoxic properties upon treatment with nicotine have been reported in several studies, but the underlying mechanisms remain not fully defined.
Khalil Hajiasgharzadeh, Mohammad Hossein Somi, Behzad Mansoori, Mohammad Amin Doustvandi, Fatemeh Vahidian, Mohsen Alizadeh, Ahad Mokhtarzadeh, Dariush Shanehbandi, Behzad Baradaran   +8 more
doaj   +1 more source

Dual impact of smoking cessation and post‐cessation weight change on psoriasis

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 285-295, February 2026.
Although smoking cessation generally reduced the risk of psoriasis, especially psoriasis vulgaris and palmoplantar pustulosis, post‐cessation weight gain weakened this benefit, mainly for psoriasis vulgaris. Nonetheless, cessation maintained a substantial protective effect against palmoplantar pustulosis, and long‐term advantages outweighed the adverse
Seong Rae Kim, Young‐Geun Choi, Seong Jin Jo   +2 more
wiley   +1 more source

in situ hybridization of alpha7 nAChR

, 2019
in situ hybridization of alpha7 nAChR in hippocampal and septal brain slices from mice with floxed a7 nAChR crossed with Cre lines expressed under Gad2, CaMKII, and Sst ...
Zhenglin Gu (7174931)
core   +2 more sources

How Do Unexpected Networks Help Female Entrepreneurs in the Global South Survive in Adverse Contexts? A Case Study of Bangladesh

Gender, Work &Organization, Volume 33, Issue 1, Page 132-163, January 2026.
ABSTRACT This study investigates the role of various unexpected networks in supporting the survival of female‐owned SMEs in the Global South. The research focuses upon Bangladesh, which is a context marked by institutional adversity and postcolonial legacies.
Sharmin Nahar, Mohammed Shamsul Karim, Vania Sena   +2 more
wiley   +1 more source

Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis.

, 2008
BACKGROUND: The efferent vagus nerve can inhibit inflammation via interaction between acetylcholine and alpha7 cholinergic receptors. METHODS: To determine the role played by alpha7 receptors in antibacterial defense, peritonitis was induced in alpha7 ...
van den Pangaart, Petra S., Goldman, Michel, Giebelen, Ilona A. J., van der Poll, Tom, Florquin, Sandrine, van den Pangaart, Petra S, Giebelen, Ilona A J, Le Moine, Alain, Sadis, Claude   +8 more
core   +1 more source

Comparative functional expression of nAChR subtypes in rodent DRG neurons

Frontiers in Cellular Neuroscience, 2013
We investigated the functional expression of nicotinic acetylcholine receptors (nAChRs) in heterogeneous populations of dissociated rat and mouse lumbar dorsal root ganglion (DRG) neurons by calcium imaging.
Nathan J. Smith, Arik J. Hone, Tosifa eMemon, Simon eBossi, Thomas E. Smith, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Baldomero M. Olivera, Russell W. Teichert   +9 more
doaj   +1 more source

Characterization of a Bovine Serum Albumin‐Derived Pro‐Cognitive Peptide (bSAPP): An Orally Active Peptide Alleviates Cognitive Decline in HFD‐Fed Mice via CCK Signaling Through the Gut‐Brain Axis

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
The popularity of the Western diet has increased the prevalence of dementia in addition to aging. We found that the digest of bovine serum albumin and a peptide derived from the digest showed an oral pro‐cognitive effect in mice fed a high‐fat diet (HFD). We named the peptide bSAPP (EC50 = 0.01 mg/kg BW). The oral effect of bSAPP was modulated by CCK1R
Biyun Zhang, Mone Ando, Kohei Kawano, Yusaku Iwasaki, Kazuo Inoue, Kousaku Ohinata   +5 more
wiley   +1 more source

Serotonin antagonizes the human neuronal alpha7 nicotinic acethylcholine receptor and becomes an agonist after L248T alpha7 mutation

, 2002
The effects of serotonin (5-hydroxytryptamine or 5HT) on chick alpha7 nicotinic receptors have already been described. However similar studies on human alpha7 receptors have been lacking.
FUCILE, Sergio, PALMA, Eleonora, EUSEBI, Fabrizio, M.I.L.E.D.I. R.   +3 more
core   +1 more source

Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants

, 1997
International audienceMutation of the conserved leucine residue, in the second transmembrane domain of the neuronal alpha7 acetylcholine receptor to a threonine (L247T) causes pleiotropic alterations of receptor properties.
Palma, Eleonora, Buisson, Bruno, Edelstein, Stuart, J., Bertrand, Daniel, Bertrand, Sonia, Devillers-Thiéry, Anne, Corringer, Pierre-Jean, Changeux, Jean-Pierre   +7 more
core   +3 more sources

Copy number variations in healthy subjects. Case study: iPSC line CSSi005-A (3544) production from an individual with variation in 15q13.3 chromosome duplicating gene CHRNA7

Stem Cell Research, 2018
CHRNA7, encoding the neuronal alpha7 nicotinic acetylcholine receptor (a7nAChR), is highly expressed in the brain, particularly in the hippocampus. It is situated in the 15q13.3 chromosome region, frequently associated with a Copy Number Variation (CNV),
Elisa Maria Turco, Ersilia Vinci, Filomena Altieri, Daniela Ferrari, Barbara Torres, Marina Goldoni, Giuseppe Lamorte, Ada Maria Tata, Gianluigi Mazzoccoli, Diana Postorivo, Matteo Della Monica, Laura Bernardini, Angelo Luigi Vescovi, Jessica Rosati   +13 more
doaj   +1 more source