Results 41 to 50 of about 5,544 (202)
Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials. [PDF]
PLoS ONE, 2009 Acetylcholine (ACh) contributes to learning processes by modulating cortical plasticity in terms of intensity of neuronal activity and selectivity properties of cortical neurons.
Jun Il Kang, Elvire Vaucher
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Frontiers in Behavioral Neuroscience, 2023 Rationale and Objectives: Ethanol acts directly on the α7 Nicotinic acetylcholine receptor (α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences during adulthood, and data indicate that the α7 receptor regulates these damaging ...
Zachary A. Rodd +19 more
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Molecules, 2021 We previously reported that lipopolysaccharide (LPS) challenge caused microglial-mediated neuroinflammation and sickness behavior that was amplified in aged mice.
Elisa Navarro +4 more
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Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration [PDF]
Neuroscience & Biobehavioral Reviews, 2008 Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people worldwide. Classical studies focused on the description and characterization of the pathological hallmarks found in AD patients including the neurofibrillary tangles and the amyloid plaques.
Concepcion, Conejero-Goldberg +2 more
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Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids [PDF]
Brain Research, 2010 The alpha7 subunit of the nicotinic acetylcholine receptor (NAchRalpha7) is one of the principal brain receptors for nicotine and is thought to be a mediator of nicotine's pro-cognitive effects. While nicotine is known to interact with the stress axis, little is known about the effect of stress or corticosteroids on the expression in the hippocampus, a
Richard G, Hunter +3 more
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Journal of Neuroinflammation, 2010 Background A major site of initiation of inflammatory responses upon physical perturbation(s) and infection by invading organisms is the skin. Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor ...
Osborne Amber V +3 more
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Frontiers in Immunology, 2017 Alpha7 nicotinic acetylcholine receptor (α7nAChR) has been reported to alleviate neuroinflammation. Here, we aimed to determine the role of autophagy in α7nAChR-mediated inhibition of neuroinflammation and its underlying mechanism.
Bo-Zong Shao +8 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2017 It has been shown that chronic stress-induced depression is associated with exaggerated inflammatory response in the brain. Alpha7 nicotinic acetylcholine receptors (α7nAChRs) regulate the cholinergic anti-inflammatory pathway, but the role of ...
Dan Zhao +7 more
semanticscholar +1 more source
Alpha7 Helix Plays an Important Role in the Conformational Stability of PTP1B
Journal of Biomolecular Structure and Dynamics, 2011 The C-terminus of Protein Tyrosine Phosphatase 1B (PTP1B) includes an α-helix α7), which forms an allosteric binding site 20 å away from the active site. This helix is specific to PTP1B and its truncation decreases the catalytic activity significantly.
Olmez, Elif Ozkirimli, Alakent, Burak
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NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.
PLoS Biology, 2012 Muscular dystrophies are common, currently incurable diseases. A subset of dystrophies result from genetic disruptions in complexes that attach muscle fibers to their surrounding extracellular matrix microenvironment.
Michelle F Goody +5 more
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