Results 1 to 10 of about 32,846 (260)

Silent agonists for α7 nicotinic acetylcholine receptors

Pharmacological Research, 2023
We discuss models for the activation and desensitization of α7 nicotinic acetylcholine receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators (PAMs) that destabilize α7 desensitized states.
Roger L. Papke, Marta Quadri, Alican Gulsevin   +2 more
doaj   +3 more sources

Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1β Release by Pulmonary Epithelial Cells [PDF]

Molecules, 2018
Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood.
Katrin Richter, Christian Koch, Alexander Perniss, Philipp M. Wolf, Elke K. H. Schweda, Sven Wichmann, Sigrid Wilker, Ilona Magel, Michael Sander, J. Michael McIntosh, Winfried Padberg, Veronika Grau   +11 more
doaj   +3 more sources

Investigation of varenicline and tropisetron in latent inhibition and novel object recognition in mice [PDF]

Scientific Reports
There is currently no treatment for cognitive-impairment associated with schizophrenia (CIAS). Animal and human studies suggest that nicotinic cholinergic agonists and 5-HT3 antagonists have potential therapeutic benefits.
Lorena R. Lizarraga-Valderrama, Stuart Williams, David J. G. Watson, Kiri T. Granger, Claire L. Gibson, Paula M. Moran   +5 more
doaj   +2 more sources

A Systematic Review on Drugs Acting as Nicotinic Acetylcholine Receptor Agonists in the Treatment of Dementia

Cells
Acetylcholine signaling is attenuated in early Alzheimer’s disease (AD) and other dementias. A significant reduction in the expression of nicotinic acetylcholine receptors (nAChRs) in the brain of AD patients has also been reported in several molecular ...
Alessio Crestini, Elena Carbone, Roberto Rivabene   +2 more
exaly   +3 more sources

Cholinergic network modulation in disinhibited eating behavior [PDF]

Communications Biology
Cholinergic modulation of brain reward circuitry appears to play a crucial role in information processing about salience as a key biological mechanism in obesity. However, changes in acetylcholine transmission leading to abnormal eating behavior have not
Swen Hesse, Michael Rullmann, Tilman Günnewig, Eva Schweickert de Palma, Lara Burmeister, Max van Grinsven, Franziska Zientek, Julia Luthardt, Mohammed K. Hankir, Philipp M. Meyer, Georg-Alexander Becker, Marianne Patt, Peter Brust, Burkhard Pleger, Michael Stumvoll, Anja Hilbert, Matthias Blüher, Osama Sabri   +17 more
doaj   +2 more sources

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition [PDF]

Nature Communications
The α6β4 nicotinic acetylcholine receptor (nAChR) is found in the sensory neurons of dorsal root ganglia. It is a promising therapeutic target for pain.
Jiawei Su, Zhuoya Yu, Zhengji Yin, Zixuan Zhang, Jun Zhao, Yufei Meng, Renjie Li, Yiwei Gao, Hongwei Zhang, Rilei Yu, Yan Zhao   +10 more
doaj   +2 more sources

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

eLife, 2022
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cellular
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester   +18 more
doaj   +1 more source

Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity. [PDF]

PLoS ONE, 2012
Sepsis is one of the leading causes of acute kidney injury (AKI). Septic patients who develop acute kidney injury (AKI) are at increased risk of death. To date there is no effective treatment for AKI or septic AKI.
Prodyot K Chatterjee, Michael M Yeboah, Oonagh Dowling, Xiangying Xue, Saul R Powell, Yousef Al-Abed, Christine N Metz   +6 more
doaj   +1 more source

Acute activation, desensitization and smoldering activation of human acetylcholine receptors. [PDF]

PLoS ONE, 2013
The behavioral effects of nicotine and other nicotinic agonists are mediated by AChRs in the brain. The relative contribution of acute activation versus chronic desensitization of AChRs is unknown. Sustained "smoldering activation" occurs over a range of
Barbara G Campling, Alexander Kuryatov, Jon Lindstrom   +2 more
doaj   +1 more source

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators

Molecules, 2023
Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent agonists, allosteric activating PAMs and neutral or silent allosteric modulators are compounds capable of modulating the nicotinic receptor by interacting at allosteric ...
Dina Manetti, Silvia Dei, Hugo R. Arias, Laura Braconi, Alessio Gabellini, Elisabetta Teodori, Maria Novella Romanelli   +6 more
doaj   +1 more source