Results 21 to 30 of about 17,562 (163)

Nicotine receptor partial agonists for smoking cessation

Cochrane Database of Systematic Reviews, 2023
Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). This is an update of a Cochrane Review first published in 2007.To assess the effectiveness of nicotine ...
Livingstone-Banks, J, Fanshawe, TR, Thomas, KH, Theodoulou, A, Hajizadeh, A, Hartman, L, Lindson, N   +6 more
openaire   +4 more sources

Acute Administration of Desformylflustrabromine Relieves Chemically Induced Pain in CD-1 Mice

Molecules, 2019
Neuronal nicotinic acetylcholine receptors are cell membrane-bound ion channels that are widely distributed in the central nervous system. The α4β2 subtype of neuronal nicotinic acetylcholine receptor plays an important role in modulating the ...
Loni A. Weggel, Anshul A. Pandya
doaj   +1 more source

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors [PDF]

Frontiers in Pharmacology, 2017
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, using [125I]-epibatidine binding, whole-cell patch-clamp recordings, synaptosomal 86Rb+ efflux, [3H]-dopamine release, and
Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester   +12 more
openaire   +5 more sources

Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation

BMC Neuroscience, 2018
Background The treatment of Parkinson’s disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditions of severe dopaminergic ...
Sakari Leino, Samuel Kohtala, Tomi Rantamäki, Sini K. Koski, Saara Rannanpää, Outi Salminen   +5 more
doaj   +1 more source

Nicotine receptor partial agonists for smoking cessation [PDF]

Cochrane Database of Systematic Reviews, 2016
Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist).To review the efficacy of nicotine receptor partial agonists, including varenicline and cytisine, for smoking ...
Cahill, Kate, Lindson-Hawley, Nicola, Thomas, Kyla H, Fanshawe, Thomas R, Lancaster, Tim   +4 more
openaire   +16 more sources

Agonist activation of a nicotinic acetylcholine receptor [PDF]

Neuropharmacology, 2015
How does an agonist activate a receptor? In this article I consider the activation process in muscle nicotinic acetylcholine receptors (AChRs), a prototype for understanding the energetics of binding and gating in other ligand-gated ion channels. Just as movements that generate gating currents activate voltage-gated ion channels, movements at binding ...
openaire   +2 more sources

Suppression of methamphetamine-seeking behavior by nicotinic agonists [PDF]

Proceedings of the National Academy of Sciences, 2006
To understand the mechanism of methamphetamine (MAP) craving from the viewpoint of nicotinic acetylcholinergic transmission, we examined the responsible site of the brain for anticraving effects produced by nicotinic agonists by using a MAP self-administration paradigm in rats.
Takato, Hiranita, Yoko, Nawata, Katsuya, Sakimura, Kusnandar, Anggadiredja, Tsuneyuki, Yamamoto   +4 more
openaire   +2 more sources

Developmental sex differences in nicotinic currents of prefrontal layer VI neurons in mice and rats.

PLoS ONE, 2010
BackgroundThere is a large sex difference in the prevalence of attention deficit disorder; yet, relatively little is known about sex differences in the development of prefrontal attention circuitry.
Nyresa C Alves, Craig D C Bailey, Raad Nashmi, Evelyn K Lambe   +3 more
doaj   +1 more source

Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos

Química Nova, 2006
Anatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent
Vania Rodríguez, Sidnei Moura, Ernani Pinto, Claudio M. P. Pereira, Rodolpho Campos Braga   +4 more
doaj   +1 more source

The Association Between Vascular Inflammation and Depressive Disorder. Causality, Biomarkers and Targeted Treatment

Pharmaceuticals, 2020
Diabetes, obesity, atherosclerosis, and myocardial infarction are frequently co-morbid with major depressive disorder. In the current review, it is argued that vascular inflammation is a factor that is common to all disorders and that an endothelial ...
Hans O. Kalkman
doaj   +1 more source