Results 11 to 20 of about 143,741 (208)
Co-activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease. [PDF]
Adv Sci (Weinh)ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Lee R, Kim G, Black ER, Kim S.
europepmc +2 more sources
Medicina, 2015 Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas +2 more
doaj +1 more source
Neonicotinoids disrupt memory, circadian behaviour and sleep
Scientific Reports, 2021 Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids are nicotinic acetylcholine receptor agonists.
Kiah Tasman +4 more
doaj +1 more source
Frontiers in Psychiatry, 2021 Background: Schizophrenia is a severe and enduring disease and is one of the leading causes of disability worldwide. Cognitive impairment is a core clinical symptom that plays a crucial role in functional outcomes and prognosis, thus making it a relevant
María Recio-Barbero +15 more
doaj +1 more source
Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]
, 2011 The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
core +1 more source
Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides [PDF]
, 2009 Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E. +14 more
core +2 more sources
Nicotinic acid receptor agonists impair myocardial contractility by energy starvation [PDF]
, 2020 Nicotinic acid receptor agonists have previously been shown to cause acute reductions in cardiac contractility. We sought to uncover the changes in cardiac metabolism underlying these alterations in function.
Lewis, Andrew J +8 more
core +1 more source
Nicotine addiction : a review [PDF]
, 2013 Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core +1 more source
A intrigante bioquímica da niacina: uma revisão crítica
Química Nova, 2011 Niacin (nicotinamide, nicotinic acid) interferes on homeostasis, DNA regulation, signaling and longevity. Nicotinic acid reduces synthesis of lipoproteins-apo-B and increases HDL.
Carlos Alberto Bastos de Maria +1 more
doaj +1 more source
eNeurologicalSci, 2022 Diabetic peripheral neuropathy (DPN) is a medical condition that is progressively becoming more prevalent. The underlying cause of DPN is still unknown, although there have been several hypothesized mechanisms. There are current pharmaceutical treatments
Sarah Westlake +3 more
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