Results 11 to 20 of about 17,562 (163)

Investigation of varenicline and tropisetron in latent inhibition and novel object recognition in mice [PDF]

Scientific Reports
There is currently no treatment for cognitive-impairment associated with schizophrenia (CIAS). Animal and human studies suggest that nicotinic cholinergic agonists and 5-HT3 antagonists have potential therapeutic benefits.
Lorena R. Lizarraga-Valderrama, Stuart Williams, David J. G. Watson, Kiri T. Granger, Claire L. Gibson, Paula M. Moran   +5 more
doaj   +2 more sources

Neonicotinoids disrupt memory, circadian behaviour and sleep

Scientific Reports, 2021
Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids are nicotinic acetylcholine receptor agonists.
Kiah Tasman, Sergio Hidalgo, Bangfu Zhu, Sean A. Rands, James J. L. Hodge   +4 more
doaj   +1 more source

Cognitive Enhancers in Schizophrenia: A Systematic Review and Meta-Analysis of Alpha-7 Nicotinic Acetylcholine Receptor Agonists for Cognitive Deficits and Negative Symptoms

Frontiers in Psychiatry, 2021
Background: Schizophrenia is a severe and enduring disease and is one of the leading causes of disability worldwide. Cognitive impairment is a core clinical symptom that plays a crucial role in functional outcomes and prognosis, thus making it a relevant
María Recio-Barbero, Rafael Segarra, Rafael Segarra, Rafael Segarra, Rafael Segarra, Arantzazu Zabala, Arantzazu Zabala, Arantzazu Zabala, Eduardo González-Fraile, Ana González-Pinto, Ana González-Pinto, Ana González-Pinto, Ana González-Pinto, Javier Ballesteros, Javier Ballesteros, Javier Ballesteros   +15 more
doaj   +1 more source

A intrigante bioquímica da niacina: uma revisão crítica

Química Nova, 2011
Niacin (nicotinamide, nicotinic acid) interferes on homeostasis, DNA regulation, signaling and longevity. Nicotinic acid reduces synthesis of lipoproteins-apo-B and increases HDL.
Carlos Alberto Bastos de Maria, Ricardo Felipe Alves Moreira   +1 more
doaj   +1 more source

Letters to the editor: Nicotinic acetylcholine receptor ligands as potential targets for managing neuropathic pain induced by diabetic peripheral neuropathy

eNeurologicalSci, 2022
Diabetic peripheral neuropathy (DPN) is a medical condition that is progressively becoming more prevalent. The underlying cause of DPN is still unknown, although there have been several hypothesized mechanisms. There are current pharmaceutical treatments
Sarah Westlake, Matthew Jones, Krishna D. Sharma, Jennifer Yanhua Xie   +3 more
doaj   +1 more source

Nicotinic Receptor Activity Alters Synaptic Plasticity

The Scientific World Journal, 2001
Studies using specific agonists, antagonists, and lesions have shown that nicotinic cholinergic systems participate in attention, learning, and memory[1,2].
John A. Dani
doaj   +1 more source

Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists [PDF]

British Journal of Pharmacology, 1999
The dose‐response parameters of recombinant mouse adult neuromuscular acetylcholine receptor channels (nAChR) activated by carbamylcholine, nicotine, muscarine and oxotremorine were measured. Rate constants for agonist association and dissociation, and channel opening and closing, were estimated from single‐channel kinetic analysis.
G, Akk, A, Auerbach
openaire   +2 more sources

Nicotinic cholinergic system and COVID-19: In silico evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions

Toxicology Reports, 2021
SARS-CoV-2 infection was announced as a pandemic in March 2020. Since then, several scientists have focused on the low prevalence of smokers among hospitalized COVID-19 patients. These findings led to our hypothesis that the Nicotinic Cholinergic System (
Nikolaos Alexandris, George Lagoumintzis, Christos T. Chasapis, Demetres D. Leonidas, Georgios E. Papadopoulos, Socrates J. Tzartos, Aristidis Tsatsakis, Elias Eliopoulos, Konstantinos Poulas, Konstantinos Farsalinos   +9 more
doaj   +1 more source

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10

Frontiers in Cellular Neuroscience, 2017
Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of α7, α9 and/or α10 subunits ...
Anna Zakrzewicz, Katrin Richter, Alisa Agné, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Mike Althaus, Mike Althaus, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Veronika Grau, Veronika Grau   +17 more
doaj   +1 more source

Small molecule ligands for α9 * and α7 nicotinic receptors: A survey and an update, respectively

Pharmacological Research, 2023
The α9- and α7-containing nicotinic acetylcholine receptors (nAChRs) mediate numerous physiological and pathological processes by complex mechanisms that are currently the subject of intensive study and debate.
Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi   +2 more
doaj   +1 more source