Results 31 to 40 of about 17,562 (163)

Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons

Frontiers in Neural Circuits, 2017
Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed ...
Jose L. Herrero, Marc A. Gieselmann, Alexander Thiele   +2 more
doaj   +1 more source

Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning. [PDF]

PLoS ONE, 2017
Agonists at the nicotinic acetylcholine alpha 7 receptor (nAChR α7) subtype have the potential to treat cognitive deficits in patients with Alzheimer's disease (AD) or schizophrenia.
Michael R Weed, Joseph Polino, Laura Signor, Mark Bookbinder, Deborah Keavy, Yulia Benitex, Daniel G Morgan, Dalton King, John E Macor, Robert Zaczek, Richard Olson, Linda J Bristow   +11 more
doaj   +1 more source

Potentiation and allosteric agonist activation of α7 nicotinic acetylcholine receptors: binding sites and hypotheses

Pharmacological Research, 2023
Considerable progress has been made in recent years towards the identification and characterisation of novel subtype-selective modulators of nicotinic acetylcholine receptors (nAChRs).
Victoria R. Sanders, Neil S. Millar
doaj   +1 more source

Reduced levels of Aβ 40 and Aβ 42 in brains of smoking controls and Alzheimer's patients

Neurobiology of Disease, 2004
The effects of nicotine on levels of Aβ 40 and Aβ 42 and nicotinic receptor binding sites were studied in brains from nonsmoking and smoking patients with Alzheimer's disease (AD) and aged-matched controls.
E Hellström-Lindahl, M Mousavi, R Ravid, A Nordberg   +3 more
doaj   +1 more source

The GSK3-NRF2 Axis in Suicide

Psychiatry International, 2021
Mutations in the genes coding for tryptophan-hydrolase-2 and the scaffold protein FKBP5 are associated with an increased risk of suicide. The mutation in both cases enhances the enzymatic activity of glycogen synthase kinase-3 (GSK3).
Hans O. Kalkman
doaj   +1 more source

The Nicotinic Agonist Cytisine: The Role of the NH···N Interaction

The Journal of Physical Chemistry Letters, 2022
We report a detailed structural study of cytisine, an alkaloid used to help with smoking cessation, looking forward to unveiling its role as a nicotinic agonist. High-resolution rotational spectroscopy has allowed us to characterize two different conformers exhibiting axial and equatorial arrangements of the piperidinic NH group.
Raúl Aguado, Santiago Mata, Miguel Sanz-Novo, Elena R. Alonso, Iker León, José L. Alonso   +5 more
openaire   +3 more sources

Subtype-Selective Peptide and Protein Neurotoxic Inhibitors of Nicotinic Acetylcholine Receptors Enhance Proliferation of Patient-Derived Glioblastoma Cell Lines

Toxins
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, with a poor prognosis. GBM cells, which develop in the environment of neural tissue, often exploit neurotransmitters and their receptors to promote their own growth and invasion ...
Elena Gondarenko, Diana Mazur, Marina Masliakova, Yana Ryabukha, Igor Kasheverov, Yuri Utkin, Victor Tsetlin, Mikhail Shahparonov, Denis Kudryavtsev, Nadine Antipova   +9 more
doaj   +1 more source

Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type

Tumor Biology, 2018
Gastric cancer is the third leading cause of cancer-related death worldwide, but the mechanisms of gastric carcinogenesis are not completely understood.
Phu Hung Nguyen, Yann Touchefeu, Tony Durand, Philippe Aubert, Emilie Duchalais, Stanislas Bruley des Varannes, Christine Varon, Michel Neunlist, Tamara Matysiak-Budnik   +8 more
doaj   +1 more source

Nicotinic filtering of sensory processing in auditory cortex

Frontiers in Behavioral Neuroscience, 2012
Although it has been known for decades that the drug nicotine can improve cognitive function, the nature of its effects and the underlying mechanisms are not well understood.
Raju eMetherate, lrakli eIntskirveli, Hideki D. Kawai   +2 more
doaj   +1 more source

Agonist efficiency links binding and gating in a nicotinic receptor

eLife, 2023
Receptors signal by switching between resting (C) and active (O) shapes (‘gating’) under the influence of agonists. The receptor’s maximum response depends on the difference in agonist binding energy, O minus C.
Dinesh C Indurthi, Anthony Auerbach
doaj   +1 more source