Results 51 to 60 of about 5,544 (202)

Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo

Scientific Reports, 2019
Alpha7 nicotinic acetylcholine receptors (nAChRs) are promising novel targets for the treatment of neurocognitive disorders. Although the cognitive enhancer potential of alpha7 nAChR agonists and positive allosteric modulators (PAMs) has been confirmed ...
Z. K. Bali, L. V. Nagy, D. Budai, I. Hernádi   +3 more
semanticscholar   +1 more source

Identification of new bile alcohols, 5 beta-cholestane-3 alpha,7 alpha,24,26-tetrol, 5 beta-cholestane-3 alpha,7 alpha,25,26-tetrol, and 5 beta-cholestane-3 alpha,7 alpha,26,27-tetrol in human gallbladder bile.

Journal of Lipid Research, 1990
The nature of cholestanetetrols present as the glucurono-conjugates in human gallbladder bile was studied. Glucurono-conjugated bile alcohols were isolated by ion exchange chromatography and, after enzymatic hydrolysis, were fractionated by reversed ...
M Une, Y Shinonaga, N Matoba, S Kuroki, K Kihira, T Hoshita   +5 more
doaj   +1 more source

Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy

eLife, 2022
Neuromuscular electrical stimulation (NMES) allows activation of muscle fibers in the absence of voluntary force generation. NMES could have the potential to promote muscle homeostasis in the context of muscle disease, but the impacts of NMES on diseased
Elisabeth A Kilroy, Amanda C Ignacz, Kaylee L Brann, Claire E Schaffer, Devon Varney, Sarah S Alrowaished, Kodey J Silknitter, Jordan N Miner, Ahmed Almaghasilah, Tashawna L Spellen, Alexandra D Lewis, Karissa Tilbury, Benjamin L King, Joshua B Kelley, Clarissa A Henry   +14 more
doaj   +1 more source

Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling

Frontiers in Molecular Neuroscience, 2017
Despite the central role of amyloid β (Aβ) peptide in the etiopathogenesis of Alzheimer’s disease (AD), its physiological function in healthy brain is still debated.
Vesna Lazarevic, Sandra Fienko, Maria Andres‐Alonso, Daniela Anni, D. Ivanova, Carolina Montenegro‐Venegas, E. Gundelfinger, M. Cousin, Anna Fejtová   +8 more
semanticscholar   +1 more source

The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders

Scientific Reports, 2018
Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an upregulation of the α7 ...
Coral M. Capó-Vélez, Bryan Morales-Vargas, A. García-González, J. Grajales-Reyes, Manuel Delgado-Vélez, Bismark A Madera, C. Báez-Pagán, Orestes Quesada, José A. Lasalde-Dominicci   +8 more
semanticscholar   +1 more source

Retracted: A preliminary study on the quantification of soft palate movement using ultrasonography

Congenital Anomalies, Volume 63, Issue 3, Page 90-90, May 2023., 2023
Retraction: [Kumiko Fujiwara, Satoru Saitou, Naomi Nakamichi, Kei Tomihara, Hideyuki Hasegawa and Makoto Noguchi, A preliminary study on the quantification of soft palate movement using ultrasonography, Congenital Anomalies, in Early View: https://doi.org/10.1111/cga.12446]. The above article, published online on 7 October 2021 in Wiley Online Library (
wiley   +1 more source

Alpha7 Nicotinic Acetylcholine Receptor Mediates Nicotine-induced Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma HepG2 Cells [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: The cytotoxic properties upon treatment with nicotine have been reported in several studies, but the underlying mechanisms remain not fully defined.
Khalil Hajiasgharzadeh, Mohammad Hossein Somi, Behzad Mansoori, Mohammad Amin Doustvandi, Fatemeh Vahidian, Mohsen Alizadeh, Ahad Mokhtarzadeh, Dariush Shanehbandi, Behzad Baradaran   +8 more
doaj   +1 more source

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

Journal of Neuroinflammation, 2023
Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems.
Huiyang Liu, Xiaomei Zhang, Peng Shi, Jiyuan Yuan, Qiang Jia, Chao Pi, Tao Chen, Linjin Xiong, Jinglin Chen, Jia Tang, Ruxu Yue, Zerong Liu, Hongping Shen, Ying Zuo, Yumeng Wei, Ling Zhao   +15 more
doaj   +1 more source

Dual impact of smoking cessation and post‐cessation weight change on psoriasis

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 285-295, February 2026.
Although smoking cessation generally reduced the risk of psoriasis, especially psoriasis vulgaris and palmoplantar pustulosis, post‐cessation weight gain weakened this benefit, mainly for psoriasis vulgaris. Nonetheless, cessation maintained a substantial protective effect against palmoplantar pustulosis, and long‐term advantages outweighed the adverse
Seong Rae Kim, Young‐Geun Choi, Seong Jin Jo   +2 more
wiley   +1 more source

The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein

Frontiers in Cellular and Infection Microbiology
The rabies virus enters the nervous system by interacting with several molecular targets on host cells to modify behavior and trigger receptor-mediated endocytosis of the virion by poorly understood mechanisms.
Brittany C. V. O’Brien, Shelly Thao, Lahra Weber, Helen L. Danielson, Agatha D. Boldt, Karsten Hueffer, Maegan M. Weltzin   +6 more
doaj   +1 more source