Results 71 to 80 of about 5,544 (202)

Identification of (24E)-3 alpha,7 alpha-dihydroxy-5 beta-cholest-24-enoic acid and (24R,25S)-3 alpha,7 alpha,24-trihydroxy-5 beta-cholestanoic acid as intermediates in the conversion of 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid to chenodeoxycholic acid in rat liver homogenates.

Journal of Lipid Research, 1994
Studies of chemical structure of the intermediates in the biosynthetic sequence between 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid (DHCA) and chenodeoxycholic acid have been undertaken. Radiolabeled DHCA was incubated with a rat liver preparation.
M. Une, A. Inoue, T. Kurosawa, M. Tohma, T. Hoshita   +4 more
doaj   +1 more source

Matrix Metalloproteinase‐Responsive Controlled Release of Self‐Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation

Advanced Science, Volume 12, Issue 2, January 13, 2025.
After implantation of the immunoregulatory scaffold into the body, infiltrated immune cells produce MMP, enabling the degradation of MMP‐responsive hydrogels. Subsequently, galactose‐modified nanoparticles are exposed and phagocytosed by macrophages, triggering their transformation into an anti‐inflammatory phenotype.
Xing Chen, Yunlong Wu, Peng Song, Liandong Feng, Ying Zhou, Jiawei Shi, Nianguo Dong, Weihua Qiao   +7 more
wiley   +1 more source

Calcineurin Suppression of Alpha7 nAChR Currents in Xenopus Oocytes [PDF]

Biophysical Journal, 2010
As part of our study of mechanisms underlying upregulation of neuronal nicotinic acetylcholine receptors (nAChRs) in brain, due to chronic nicotine exposure, we are characterizing signaling pathways that influence the magnitude of α7 nAChR currents in Xenopus oocytes. In previous studies of Kv1.1 channels in oocytes, we found that calcineurin (CaN) and
Farley, Joseph, Hallahan, Brent, Raynor, Jordan, Neuman, Krystina, Rumers, Joseph, Rajkotia, Minesh, Rose, Jed   +6 more
openaire   +1 more source

Identification of (22R)-3 alpha,7 alpha,12 alpha,22- and (23R)-3 alpha,7 alpha,12 alpha,23-tetrahydroxy-5 beta-cholestanoic acids in urine from a patient with Zellweger's syndrome.

Journal of Lipid Research, 1989
The nature of two novel C27 bile acids present as the taurine conjugates in urine from a patient with Zellweger's syndrome was studied. Bile acids conjugated with taurine were isolated from unconjugated and glycine-conjugated bile acids by means of ion ...
M Une, K Tsujimura, K Kihira, T Hoshita
doaj   +1 more source

Ly6h Regulates Trafficking of Alpha7 Nicotinic Acetylcholine Receptors and Nicotine-Induced Potentiation of Glutamatergic Signaling

Journal of Neuroscience, 2015
α7 nAChRs are expressed widely throughout the brain, where they are important for synaptic signaling, gene transcription, and plastic changes that regulate sensory processing, cognition, and neural responses to chronic nicotine exposure.
C. Puddifoot, Meilin Wu, R. Sung, W. Joiner   +3 more
semanticscholar   +1 more source

A Review of the Role of Paraprobiotics in the Formulation of High‐Protein Ice Cream as an Advanced Functional Food

International Journal of Food Science, Volume 2025, Issue 1, 2025.
Paraprobiotics are nonvital bacteria that have health benefits. Recently, they have been incorporated into dairy products as supplements to probiotics. The advantages of using paraprobiotics mainly include superior resistance to processing conditions, extended shelf‐life, and safer consumption by people with weaker immune systems.
Seyed Ali Issazadeh, Samaneh Hatami, Ivan Salmerón   +2 more
wiley   +1 more source

Modulation of alpha7 nicotinic acetylcholine receptor by cannabidiol

, 2022
Fil: Esandi, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur.
Chrestia, Juan Facundo, Esandi, María del Carmen, Bouzat, Cecilia Beatriz   +2 more
openaire   +1 more source

Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells. [PDF]

PLoS ONE, 2009
Satellite cells are the resident stem cells of adult skeletal muscle. To date though, there is a paucity of native markers that can be used to easily identify quiescent satellite cells, with Pax7 probably being the best that is currently available.
Viola F Gnocchi, Robert B White, Yusuke Ono, Juliet A Ellis, Peter S Zammit   +4 more
doaj   +1 more source

Unveiling citicoline's mechanisms and clinical relevance in the treatment of neuroinflammatory disorders

The FASEB Journal, Volume 38, Issue 17, September 2024.
Mechanisms of citicoline in treating neuroinflammatory disorders. Abstract Citicoline, a compound produced naturally in small amounts in the human body, assumes a pivotal role in phosphatidylcholine synthesis, a dynamic constituent of membranes of neurons.
Simona Cavalu, Sameh Saber, Asmaa Ramadan, Elsayed A. Elmorsy, Rabab S. Hamad, Mustafa Ahmed Abdel‐Reheim, Mahmoud E. Youssef   +6 more
wiley   +1 more source

GSK3: A potential target and pending issues for treatment of Alzheimer's disease

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
GSK3 signaling in Alzheimer's disease and targeted therapies. Abstract Glycogen synthase kinase‐3 (GSK3), consisting of GSK3α and GSK3β subtypes, is a complex protein kinase that regulates numerous substrates. Research has observed increased GSK3 expression in the brains of Alzheimer's disease (AD) patients and models.
Jiahui Zhao, Mengying Wei, Minsong Guo, Mengyao Wang, Hongxia Niu, Tengfei Xu, Yuan Zhou   +6 more
wiley   +1 more source