Results 81 to 90 of about 4,718 (156)

Association of nicotinic acetylcholine receptors with central respiratory control in isolated brainstem-spinal cord preparation of neonatal rats

Biological Research, 2006
Nicotine exposure is a risk factor in several breathing disorders Nicotinic acetylcholine receptors (nAChRs) exist in the ventrolateral medulla, an important site for respiratory control.
EIKI HATORI, SHIGEKI SAKURABA, MASANORI KASHIWAGI, JUNYA KURIBAYASHI, MIKI TSUJITA, YUKI HOSOKAWA, JUNZO TAKEDA, SHUN-ICHI KUWANA   +7 more
doaj  

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

, 2008
Positive allosteric modulators of alpha7 nicotinic acetylcholine receptors (nAChRs) have attracted considerable interest as potential tools for the treatment of neurological and psychiatric disorders such as Alzheimer's disease and schizophrenia. However,
Young, GT, Zwart, R, Walker, AS, Sher, E, Millar, NS   +4 more
core   +1 more source

Synthesis of potential cholelitholytic agents: 3 alpha,7 alpha,12 alpha-trihydroxy-7 beta-methyl-5 beta-cholanoic acid, 3 alpha,7 beta,12 alpha-trihydroxy-7 alpha-methyl-5 beta-cholanoic acid, and 3 alpha,12 alpha-dihydroxy-7 xi-methyl-5 beta-cholanoic acid.

Journal of Lipid Research, 1985
This report describes the chemical synthesis of six new bile acid analogs, namely, 3 alpha,7 alpha,12 alpha-trihydroxy-7 beta-methyl-5 beta-cholanoic acid (7 beta-methyl-cholic acid), 3 alpha,7 beta,12 alpha-trihydroxy-7 alpha-methyl-5 beta-cholanoic ...
S Kuroki, M Une, E H Mosbach
doaj   +1 more source

Hippocampal asymmetry and regional dispersal of nAChRs alpha4 and alpha7 subtypes in the adult rat

, 2021
To better comprehend the relationship between left/right (L/R) differences and hippocampus functions is necessary knowledge of lateral asymmetry and regional distribution.
Rahimian, N., Jaberi, N., Khorasgani, E.M., Delavar, A., Baradaran, R., Anbarkeh, F.R., Abbasi, Y.   +6 more
core  

Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation.

, 2008
OBJECTIVES: Lung cancer is the most common cause of cancer death in the world. Cigarette smoking represents the major risk factor. Nicotine, an active component of cigarettes, can induce cell proliferation, angiogenesis and apoptosis resistance.
Cesario, Alfredo, Granone, Pierluigi
core   +1 more source

New Pyridyl and Dihydroisoquinoline Alkaloids Isolated from the Chevron Nemertean Amphiporus angulatus

Marine Drugs
Nemertean worms contain toxins that are used to paralyze their prey and to deter potential predators. Hoplonemerteans often contain pyridyl alkaloids like anabaseine that act through nicotinic acetylcholine receptors and crustacean chemoreceptors.
William R. Kem, Ferenc Soti, James R. Rocca, Jodie V. Johnson   +3 more
doaj   +1 more source

Expression of an alpha7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes

, 2002
We examined the potential expression and function of alpha7 nicotinic acetylcholine receptors (nAChRs) in leukocytes. RT-PCR with alpha7 specific primers revealed the presence of the receptor mRNA in leukocytes.
Villiger, Y., Szanto, Ildiko, Krause, Karl-Heinz, Bertrand, Daniel, Blanchet, Christophe, Buisson, B., Jaconi, S., Romand, Jacques-André   +7 more
core   +1 more source

Alpha7 and alpha8 nicotinic receptor subtypes immunopurified from chick retina have different immunological, pharmacological and functional properties

, 1997
Nicotinic receptors are present in the chick retina, but their structure and functional characteristics are still unclear. Using anti-alpha7 and anti-alpha8 subunit-specific antibodies, we immunopurified the alpha7 and alpha8 subtypes of chick retina ...
W. Hanke, R. Maggi, N. Klinke, F. Clementi, R. Longhi, C. Gotti, M. Moretti   +6 more
core   +1 more source

A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain

, 2001
International audienceWe describe the construction of a soluble protein carrying the N-terminal extracellular domain (ECD) of the alpha7 subunit of the nicotinic acetylcholine receptor.
Schott, Karin, Corringer, Pierre-Jean, Bacher, Adelbert, Fischer, Markus, Changeux, Jean-Pierre   +4 more
core   +1 more source

Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

, 2010
BACKGROUND AND PURPOSE: In various models vagus nerve activation has been shown to ameliorate intestinal inflammation, via nicotinic acetylcholine receptors (nAChRs) expressed on immune cells.
Lee, Kevin, Verstege, Marleen I., Snoek, Susanne A., van der Zanden, Esmerij P., Boeckxstaens, Guy E., Bulmer, David C., Skynner, Michael, de Jonge, Wouter J., Deeks, Nigel, te Velde, Anje A.   +9 more
core   +1 more source